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Expression and localization of CHODLDeltaE/CHODLfDeltaE, the soluble isoform of chondrolectin

, : Expression and localization of CHODLDeltaE/CHODLfDeltaE, the soluble isoform of chondrolectin. Cell Biology International 31(11): 1323-1330

The C-type lectin family is a group of animal proteins which can be distinguished from other lectins by the presence of a Ca2+-dependent carbohydrate recognition domain (CRD) in their protein sequence. They are classified into 17 groups according to their domain architecture and have a wide variety of functions. The human chondrolectin gene encodes transmembrane (CHODL, CHODLf) and soluble proteins (CHODL Delta E, CHODLf Delta E) belonging to the family of C-type lectins because of the presence of one CRD domain in their N-terminal region. The CHODL splice variants (CHODLf, CHODL Delta E and CHODLf Delta E) are differentially expressed in T lymphocytes. The transmembrane-containing isoform CHODLf is localized in the ER-Golgi apparatus. CHODL Delta E and CHODLf Delta E are devoid of the transmembrane domain and terminate in QDEL, an ER retention signal. In this paper we have investigated the expression of the CHODL Delta E/CHODLf Delta E protein. This variant localizes in the late endoplasmic reticulum. We detected the protein in spleen and tonsils in a small population of lymphocytes. Moreover, the isoform seems to be differentially expressed in thymocytes and lymphocytes suggesting an important biological function during T cell development.


PMID: 17606388

DOI: 10.1016/j.cellbi.2007.05.014

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Billheimer, J.T.; Seiffert, D.A.; Breth, L.A.; Burn, T.C.; Dicker, I.B.; George, H.J.; Hollis, G.F.; Hollis, J.M.; Kochie, J.E.; O'neil, K.T., 2003: Detection of patients at risk for developing integrin antagonist/agonist mediated disease states. This invention relates to the detection of patients at risk for developing integrin antagonist/agonist mediated disease states. This invention relates to assays useful for the detection in a patient bodily fluid sample of drug-dependent antibodies...

Pfeiffer, Thekla., 1997: The fossil fallow deer of the Upper Rhine Valley in comparison to Dama dama from Neumark-Nord Saxony-Anhalt, Lehringen Lower-Saxony and the recent European fallow deer Die fossilen Damhirsche der Oberrheinebene im Vergleich zu Dama dama aus Neumark-Nord Sachsen-Anhalt, Lehringen Niedersachsen und dem rezenten europaischen Damhirsch. Zeitschrift fuer Jagdwissenschaft. Dezember; 434: 221-239

Vach, B., 1975: Our experiences with liver injuries during the last 10 years. Rozhledy V Chirurgii 54(5): 307-310

McColloch Jane S.; McColloch Gayle H.J., 1998: Digital derivative maps for informed decision making. Critical land-use decisions are made daily. Often decision makers are nongeologists who, when considering the suitability of sites for various purposes, overlook or misinterpret geologic information. Although relevant geologic information is often...

Hamdorf, G.; Lesemann, D.E.; Weidemann, H.L., 1977: Investigations on rhizomania disease of sugar beet in the Federal Republic Germany. Symptoms including root proliferation, observed in 1974-75 on sugar beet near Frankfurt, W. Germany, suggests the probable relation of the disease with rhizomania [RPP 54, 4216]. Rod-shaped particles 110-120 and 290-310 nm long and 15-18 nm diam.,...

Tenovuo, Rauno, 1963: The problem of the rock dove Columba livia and its increase. The rock dove has recently been noticed because it harbors ornithosis virus. In Finland it has recently increased and spread, breeding under stone bridges or on rock ledges.

Kozma, J.J., 1965: Use of quinethazone combined with reserpine in hypertension. Folha Medica 50(6): 413-417

Carter, D.L.; Robbins, C.W., 1978: Salt outflows from new and old irrigated lands. Three water application treatments with low salt water were applied to previously nonirrigated soil and to a similar soil which had been irrigated for 67 years. The total soluble salt content of these soils initially, and after one and two seasons...

Ilmurzyńska, K.; Dorywalski, A., 1972: Electrocardiography in hypertrophic cardiomyopathy. Polski Tygodnik Lekarski 27(29): 1121-1123

Huchzermeyer, F.W.; Gerdes, G.H., 1993: Newcastle disease virus isolated from ostriches in South Africa. Journal of the South African Veterinary Association 64(4): 140-140