geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Expression levels of cyclooxygenase-2, tumor necrosis factor-α and inducible NO synthase in placental tissue of normal and preeclamptic pregnancies


, : Expression levels of cyclooxygenase-2, tumor necrosis factor-α and inducible NO synthase in placental tissue of normal and preeclamptic pregnancies. Journal of Maternal-Fetal & Neonatal Medicine 25(6): 826-830

Although preeclampsia (PE) is one of the most important problems affecting pregnant women, etiologic factors in its development are still unclear. We aimed to investigate the expression levels of cyclooxygenase-2 (COX-2), tumor necrosis factor-α (TNF-α) and inducible NO synthase (iNOS) in preeclamptic and healthy control placentas. Placental tissue samples were obtained after delivery from patients diagnosed with PE and from normal-term pregnants and analyzed for COX-2, TNF-α and iNOS expression by immunohistochemistry. A strong expression of COX-2 was observed in syncytiotrophoblast cells of preeclamptic placentas, which was significantly higher than that of normal placentas (p = 0.005). A mild expression of TNF-α in both normal and preeclamptic syncytiotrophoblasts was seen (p = 0.435). In addition, a strong expression of iNOS in normal syncytiotrophoblasts was found, but the intensity of the iNOS expression was highly reduced in preeclamptic placentas (p = 0.001). No correlation was detected between COX-2, TNF-α and iNOS expression levels. The findings of a decrease of iNOS expression and an increase of COX-2 expression in placenta suggest the existence of functional roles of iNOS and COX-2 in the pathophysiology of PE, probably by contributing to the reduced placental blood flow and increased resistance to flow in the fetomaternal circulation.

US$19.90

PMID: 22014124

DOI: 10.3109/14767058.2011.595853


Other references

Anderson, D.R.; Zlateva, I.; Coman, E.N.; Khatri, K.; Tian, T.; Kerns, R.D., 2016: Improving pain care through implementation of the Stepped Care Model at a multisite community health center. Treating pain in primary care is challenging. Primary care providers (PCPs) receive limited training in pain care and express low confidence in their knowledge and ability to manage pain effectively. Models to improve pain outcomes have been devel...

Hill, G.F., 1926: Termites from the Ellice group. Proceedings of the Royal Society of Victoria, 38: 95-99

Skridonenko, A.D.; Gorchakova, G.A., 1975: Isolation and purification of 5 endo rnase from nuclei of the rat liver. 5'-Endoribonuclease was isolated from rat liver nuclei. It was purified 400 times by selective extraction at pH 8.0, chromatography on DEAE-cellulose-Sephadex A-50, salting out with ammonium sulfate (40-50% saturation), chromatography on a DE...

Nadelson C.C., 1986: Presidential address health care directions who cares for patients. American Journal of Psychiatry 143(8): 949-955

Dolenc, A.; Lovsin, J., 1979: Unusual suicide cases. Beitrage Zur Gerichtlichen Medizin 37: 235-240

Seaman, W.B., 1963: Hypertrophy of the pyloric muscle in adults. An analysis of 27 cases. Radiology 80: 753-764

Rashbaum, W.K.; Gates, E.J.son; Jones, J.; Goldman, B.; Morris, A.; Lyman, W.D., 1995: Placenta accreta encountered during dilation and evacuation in the second trimester. Objective: To assess the frequency of placenta accreta encountered during dilation and evacuation (D and E) in the second trimester. Methods: Among 16,827 second-trimester D and E procedures performed at our hospitals and clinics, seven cases of p...

Waters, J., 1995: The end result. Nursing Times 91(36): 14-15

Straub, R.; Mack, M.G.; Jacobi, V.; Proschek, D.; Vogl, T.J., 2006: Magnetic resonance imaging in orthopaedic medicine. Magnetic resonance imaging (MRI) is an established diagnostic tool in orthopaedics. Superior soft tissue contrast, lack of ionised radiation and free slice orientation are the key points for optimal evaluation of joint structures, muscles and liga...

Schade D.S.; Duckworth W.C.; Drumm D.A.; Eaton R.P., 1984: In search of the subcutaneous insulin degradation syndrome. Diabetologia 27(2): 327A