geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Extra-pulmonary tuberculosis: differential aspects and role of 16S-rRNA in urine


, : Extra-pulmonary tuberculosis: differential aspects and role of 16S-rRNA in urine. International Journal of Tuberculosis and Lung Disease 18(4): 478-485

Early diagnosis of extra-pulmonary tuberculosis (EPTB) is important for successful treatment. All cases of EPTB diagnosed at Ramon y Cajal Hospital, Madrid, Spain, from 1997 to 2008 were analysed and compared with pulmonary tuberculosis (PTB) patients to identify differential parameters that could serve to predict the presence of EPTB at initial presentation. Different microbiological techniques were analysed, including amplification of 16S-rRNA in urine. During the study period, 814 cases of TB were diagnosed at our centre; 330 (40.5%) were EPTB. Concomitant PTB was detected in 45% of EPTB cases. The main clinical forms of EPTB were lymphadenitis (86, 26%), miliary TB (60, 18%), and multifocal TB (43, 13%). Variables independently associated with EPTB were human immunodeficiency virus (HIV) infection (OR 3.6, 95%CI 2.4-5.4), older age (>60 years) (OR 3.7, 95%CI 2.5-5.6) and mortality (OR 2.9, 95%CI 1.3-6.3). 16S-rRNA in urine was performed in 82 EPTB patients (25%), among whom a positive result was obtained in 70%; in the PTB group, a positive result was found in 5 of 28 patients (18%) (P <0.001). HIV infection and older age appear to be the main risk factors associated with EPTB. In this study, mortality was significantly higher in patients with EPTB. A positive 16S-rRNA test result in urine is a useful marker of EPTB.

US$19.90

PMID: 24670706

DOI: 10.5588/ijtld.13.0555


Other references

Inoue, M.; Hori, M.; Nishimoto, Y.; Fukui, S.; Abe, H.; Wada, H.; Minamino, T., 1978: Immunological determination of serum m-AST activity in patients with acute myocardial infarction. Serum m-AST (mitochondrial isoenzyme of AST) activity in patients with acute myocardial infarction was determined quantitatively by a new immunological technique which is sensitive and easily available. All 31 patients with acute myocardial infarc...

Reeves-Viets, J.L.; Yawn, D.H., 1991: Impact of whole blood usage in massive transfusion. A retrospective survey comparing blood and component usage during thoracoabdominal aortic reconstruction between patients receiving whole blood vs packed red cells was conducted. Volume of salvaged blood, usage of homologous blood components, and...

Anonymous, 2013: A reduced order model for groundwater flow equation with random hydraulic conductivity Application to monte carlo methods. We present a model order reduction technique that overcomes the computational burden associated with the application of Monte Carlo methods to the solution of the groundwater flow equation with random hydraulic conductivity. The method is based on...

Aburel, E.; Petrescu, V.D.; Condrea, H., 1960: The surgical treatment of female genital tuberculosis. Zentralblatt für Gynakologie 82: 1096-1105

Noda, M.; Poulsom, R.; Hanby, A.M.; Hattori, T.; Wright, N.A., 1998: Prolonged duodenogastric reflux in the rat is followed by development of new glands resembling the ulcer-associated cell lineage. Gut 42(SUPPL 1): A87, March

Cairns, SD.; Wells, JW., 1987: Neogene paleontology in the northern Dominican Republic. 5. The suborders Caryophyllina and Dendrophyllina (Anthozoa: Scleractinia). Bulletins of American Paleontology, 93: 23-43 No. 328

Visconti M.; Frezza G.; Russo V.; Verde F., 1972: Variations in the titer of hem agglutination inhibiting antibodies to influenza virus in aged women vaccinated with bivalent anti influenza vaccine. Bollettino Societa Italiana Biologia Sperimentale 48(23): 1070-1074

Wooten, M.W.; Wrenn, R.W., 1988: Linoleic acid is a potent activator of protein kinase C type III-alpha isoform in pancreatic acinar cells; its role in amylase secretion. Linoleic acid, an unsaturated-long chain fatty acid, was found to maximally activate protein kinase C (PKC) more effectively than arachidonic or linolenic acid, while the saturated fatty acids palmitic or arachidic had no stimulatory effect. Treat...

John D.N.wman; David F.L.ndsley, 1976: Neural detection of vocalizations in squirrel monkey temporal and frontal cortex. Brain Research 107(1): 204

Churikov, D.; Corda, Y.; Luciano, P.; Géli, V., 2013: Cdc13 at a crossroads of telomerase action. Telomere elongation by telomerase involves sequential steps that must be highly coordinated to ensure the maintenance of telomeres at a proper length. Telomerase is delivered to telomere ends, where it engages single-strand DNA end as a primer, el...