geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

FSHR single nucleotide polymorphism frequencies in proven fathers and infertile men in Southeast Turkey


, : FSHR single nucleotide polymorphism frequencies in proven fathers and infertile men in Southeast Turkey. Journal of Biomedicine & Biotechnology 2010: 640318-640318

The influence of FSH receptor (FSHR) variants on male infertility is not completely understood. The present investigation is the first screening study for SNP at nucleotide position -29 in the core promoter region and codon 680 in exon 10 of the FSHR and the effect of the serum levels of FSH on male infertility in Southeast Turkey. The SNPs in codon 680 and at position -29 of the FSHR gene were analyzed by PCR-RFLP technique in 240 men with proven fathers, and 270 infertile men (150 nonobstructive azoospermic and 120 severe oligozoospermic). The separate analysis for SNP at nucleotide position -29 did not show any difference in genotypic frequencies and serum FSH levels. The genotype distribution of SNP at position 680 was different but does not influence serum FSH levels. Together the two SNPs form four discrete haplotypes (A-Thr-Asn, G-Thr-Asn, A-Ala-Ser, and G-Ala-Ser) occurring in 10 combinations. A statistically significant difference in the allelic distribution of G-Asn/G-Ser and G-Ser/G-Ser genotype between proven fathers and infertile men but there were not any statistically significant difference in the overall frequency of the four FSHR haplotypes. We conclude that the FSHR haplotype does not associate with different serum FSH levels but it is differently distributed in proven fathers and infertile men.

US$19.90

PMID: 20454649

DOI: 10.1155/2010/640318


Other references

Sugiura, A.; Utsunomiya, N.; Tomana, T., 1976: Induction of inflorescence by CCC application on primary shoots of grapevines. Various experiments using 1-year-old potted grafted vines, cv. Muscat of Alexandria, showed that under long day conditions (11 or 16 h) and low temperatures (20 deg C rather than 30 deg ), twice weekly applications of 500 p.p.m. CCC [chlormaquat]...

Jones, T.R.; Antonetti, D.L.; Reid, T.W., 1986: Aluminum ions stimulate mitosis in murine cells in tissue culture. Addition of aluminum to the culture medium of Nakano mouse lens epithelial (NMLE) cells and Swiss 3T3K cells induced both 3H-thymidine incorporation and mitosis. This is in contrast to other metal ions such as vanadium, which, at concentrations hi...

Johnson, C.E., 1918: The branchial derivatives of the Pied-billed Grebe, with special consideration of the origin of the post branchial body. Journ. Philadelphia: 25-37

Karling, John S., 1957: Synchytrium cinnamomeum. Synchytrium cinnamomeum, a parasite of Ranunculus spp., which was [image] formerly believed to be a short-cycled member of the subgenus Pycno-chytrium, is long-cycled and develops prosori, sori, sporangia, and resting spores. Accordingly, it is tr...

Anderson, Mw, 1980: Off-road motorcycling in the 1980s: what does it look like? Market, recreational use on public lands, management. Off road vehicle use: a management challenge edited by Richard NL Andrews and Paul F Nowak: 265

Rodas, B.Z. de; Maxwell, C.V.; Brock, K.S., 1995: Exogenous emulsifiers in early weaned pig diets. From 0 to 7, 7 to 21 and 21 to 35 days after being weaned, pigs in 3 groups were given a basal diet containing 4% lard and 4% soyabean oil, or that diet plus 0.1% Lysoforte or 0.02% Lysoprin (emulsifiers). Blood was taken on days 7 and 21 after we...

Sorensen, V.W., 1976: Placental fine structure after experimental embryonic death in cows. Early embryonic death was experimentally induced by amnion rupture in pregnant heifers. The subsequent morphological alterations in the placenta were studied with light and electron microscopy, histochemical tests and electron microscope microanal...

Milton, J.C.; Jackson, S.H.D., 2007: Inappropriate polypharmacy: reducing the burden of multiple medication. Clinical Medicine 7(5): 514-517

Lam, J.C.; Robinson, S.R.; Schell, A.; Vaughan, S., 2016: Pulmonary neuroendocrine carcinoma mimicking neurocysticercosis: a case report. Neurocysticercosis occurs when the eggs of the pork tapeworm (Taenia solium) migrate and hatch into larvae within the central nervous system. Neurocysticercosis is the most common cause of seizures in the developing world and is characterized on b...

Cotugno, R.; Basile, A.; Romano, E.; Gallotta, D.; Belisario, M.Antonietta., 2015: BAG3 down-modulation sensitizes HPV18(+) HeLa cells to PEITC-induced apoptosis and restores p53. BAG3 is a multi-functional component of tumor cell pro-survival machinery, and its biological functions have been largely associated to proteasome system. Here, we show that BAG3 down-modulation resulted in reduced cell viability and enhanced PEIT...