+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Female pseudohermaphroditism in a prenatally diagnosed cloacal malformation with hydronephrosis, dilated bladder, hydrometrocolpos, and oligohydramnios

, : Female pseudohermaphroditism in a prenatally diagnosed cloacal malformation with hydronephrosis, dilated bladder, hydrometrocolpos, and oligohydramnios. Taiwanese Journal of Obstetrics & Gynecology 52(4): 571-574

To present female pseudohermaphroditism in a prenatally diagnosed cloacal malformation. A 29-year-old, primigravid woman referred for counseling at 17 weeks of gestation because of oligohydramnios and an intra-abdominal cyst in the fetus. The woman was not exposed to any virilizing agent during this pregnancy. She did not undergo any assisted reproductive technology for this pregnancy. Level II ultrasound showed a singleton with fetal biometry equivalent to 16 weeks, oligohydramnios, hydrometrocolpos, dilated bladder, and bilateral hydronephrosis. A diagnosis of cloacal malformation was made. The parents elected to terminate the pregnancy at 18 weeks of gestation. A 196-g fetus was delivered with a distended abdomen, a phallus-like structure, a small perineal opening below the phallus-like structure, and an imperforate anus. At birth, the fetus was misdiagnosed as a male with an imperforate anus and a perineal fistula. Cytogenetic analysis of the cord blood revealed a karyotype of 46,XX. Array comparative genomic hybridization analysis of the fetal tissues revealed no genomic imbalance. The phallus-like structure was an enlarged clitoris and contained accessory phallic urethra. Prenatal diagnosis of cloacal malformation with ambiguous genitalia should be paid attention to avoid misdiagnosis of a male with an imperforate anus and a perineal fistula. Cytogenetic analysis is helpful to determine the sex under such circumstances.


PMID: 24411046

DOI: 10.1016/j.tjog.2013.10.021

Other references

Hanson, J.; Reynaud, D.; Qiao, N.; Devel, P.; Moray, A-Lise.; Renard, J-François.; Kelley, L.P.; Winum, J-Yves.; Montero, J-Louis.; Kinsella, B.Therese.; Pirotte, B.; Pace-Asciak, C.R.; Dogné, J-Michel., 2006: Synthesis and pharmacological evaluation of novel nitrobenzenic thromboxane modulators as antiplatelet agents acting on both the alpha and beta isoforms of the human thromboxane receptor. Thromboxane A(2) ( TXA(2)) is an arachidonic acid metabolite involved in pathologies such as stroke, myocardial infarction, and atherosclerosis. Consequently, the design of TXA2 receptor ( TP) antagonists remains of great interest in cardiovascula...

Szoszkiewicz, K.; Wakeham-Dawson, A., 1996: The impact of grazing management on plant and invertebrate populations in chalk grassland in South England Wplyw sposobu wypasania na roslinnosc i populacje bezkregowcow na pastwiskach kredowych w poludniowej Anglii. Przeglad Przyrodniczy, 73-4: 281-285

Zhu, H.; Chauhan, A., 2008: Effect of viscosity on tear drainage and ocular residence time. An increase in residence time of dry eye medications including artificial tears will likely enhance therapeutic benefits. The drainage rates and the residence time of eye drops depend on the viscosity of the instilled fluids. However, a quantitati...

Dillhoff, R.M.; Dillhoff, T.A.; Dunn, R.E.; Myers, J.A.; Stromberg, C.A.E., 2009: Cenozoic paleobotany of the John Day Basin, central Oregon. The John Day Basin of central Oregon contains a remarkably detailed and well-dated Early Eocene-Late Miocene sedimentary sequence, known for its superb fossils. This field trip examines plant fossil assemblages from throughout the sequence in the...

Sasagawa, Y.; Kamio, Y.; Matsubara, Y.; Matsubara, Y.; Suzuki, K.; Kojima, H.; Izaki, K., 1993: Purification and properties of collagenase from Cytophaga sp. L43-1 strain. A collagenolytic bacterial strain was isolated from soil and was identified as Cytophaga sp. It produced several kinds of collagenase and protease. From the supernatant of a culture, a collagenase was purified as a single protein band upon SDS-PAG...

Schawalder, P.; Jutzi, K.; Andres, H.U.; Blum, J., 2002: Die Panostitis beim Hund: Eine kryptogenetische Skeletterkrankung im Blickwinkel einer neuen aetiopathogenetischen Hypothese. Teil 2: Biochemische Aspekte und Untersuchungen. The pilot study included serum analysis of ionized calcium, copper, zinc, various hormones and amino acid profiles from dogs affected with panosteitis, as well as protein electrophoresis performed on bone biopsies. Results of these analyses are as...

Singh, L.N.K.; Singh, N.I.; Singh, L.J., 2001: Activities of Pestalotiopsis versicolor, a rare rice collar rot fungus at different environmental conditions. The effects of temperature, relative humidity (RH) and rainfall on the severity of rice collar rot (P. versicolor) on rice were evaluated during kharif 1999, at Lamphel, Manipur, India. The popular high-yielding, susceptible rice cultivar, Leima p...

Borda, J.M., 1951: Cutaneous and subcutaneous manifestations of abarticular rheumatism. Revista de la Asociacion Medica Argentina 65(707-708): 331-337

Deahl K.L.; Sinden S.L., 1987: A technique for rapid detection of leptine glycoalkaloids in potato foliage. A rapid screening procedure for detecting the presence of leptines in potato foliage was developed. The glycoalkaloids in expressed sap are separated by high performance thin-layer chromatography and detected with iodine vapor. About 80 foliage sa...

Doehrn Volker, 1992: Report 1991 on geological surveys of the Gleichenberger Kogel of Sheet 192 Feldbach. Jahrbuch der Geologischen Bundesanstalt Wien 135(3): 769-770