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Fibroblast growth factor signaling is required for the generation of oligodendrocyte progenitors from the embryonic forebrain

, : Fibroblast growth factor signaling is required for the generation of oligodendrocyte progenitors from the embryonic forebrain. Journal of Neuroscience 31(13): 5055-5066

Fibroblast growth factors (FGFs) comprise a family of developmental regulators implicated in a wide variety of neurological functions. FGF receptors 1, 2, and 3 (Fgfrs) are expressed in the embryonic forebrain, including regions overlapping with ventral sites of oligodendrocyte progenitor (OLP) generation. Although FGF signaling is known to influence the proliferation of OLPs in vitro, functions of different Fgfrs in vivo are lacking. Here, we examined single and double mutants with conditional disruption of Fgfrs, specifically in the embryonic forebrain, to investigate the effect of FGFs on the generation and proliferation of OLPs in vivo. FGF signaling, through cooperation between Fgfr1 and Fgfr2 but not Fgfr3, is required for the initial generation of OLPs in the mouse ventral forebrain, with Fgfr1 being a stronger inducer than Fgfr2. In cultures derived from embryonic mutant forebrains or from normal forebrains grown in the presence of Fgfr inhibitor, a strong attenuation of OLP generation was observed, supporting the role of FGF signaling in vivo. Contrary to in vitro findings, Fgfr1 and Fgfr2 signaling is not required for the proliferation of OLPs in vivo. Finally, failure of OLP generation in the Fgfr mutants occurred without loss of sonic hedgehog (Shh) signaling; and pharmacological inhibition of either Fgfr or hedgehog signaling in parallel cultures strongly inhibited OLP generation, suggesting that Fgfrs cooperate with Shh to generate OLPs. Overall, our results reveal for the first time an essential role of FGF signaling in vivo, where the three Fgfrs differentially control the normal generation of OLPs from the embryonic ventral forebrain.


PMID: 21451043

DOI: 10.1523/JNEUROSCI.4800-10.2011

Other references

Pieniazek, Sa, 1978: Production of fruits temeperate climate fruits in a changing world. Ogrodnictwo 15(12)

Schenone, H.; Avendano, A.; Fanta, E., 1963: Familial outbreak of hepatic distomiasis or fascioliasis. Revista Chilena de Pediatria 34: 347-352

Nolan, L.A.; Hart, E.J.; Windle, R.J.; Wood, S.A.; Hu, X.W.; Levi, A.J.; Ingram, C.D.; Levy, A., 2001: Lack of effect of protein deprivation-induced intrauterine growth retardation on behavior and corticosterone and growth hormone secretion in adult male rats: a long-term follow-up study. To further define the neuroendocrine consequences of intrauterine growth retardation (IUGR), we have used a rat model of maternal protein restriction throughout pregnancy to examine the pattern of corticosterone and GH secretion under basal condit...

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D'Agostino, R.B.; Farewell, V.; Greenhouse, J.B.; Whitehead, J., 2008: Updating our aims and scope for the future. Statistics in Medicine 28(1): 1-2

Flurkey, H.G., 1992: Albuterol. Neonatal Network 11(7): 85-87

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