geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Fifteen years' experience in thyroid surgery


, : Fifteen years' experience in thyroid surgery. Annals of the Royal College of Surgeons of England 92(7): 541-547

Thyroid disease is common, thyroid cancer is uncommon. Most goitres are investigated using blood tests, fine needle aspiration cytology together with ultrasound. Surgery usually entails either lobectomy or total thyroidectomy, and for malignancy, patients may need a neck dissection. Recently, significant advances have been made regarding mechanisms involved in both thyroid growth and function (goitrogenesis) and carcinogenesis at a molecular level. In the study cohort, 1113 patients had benign disease and 387 malignancy. For benign disease, 716 patients had lobectomy or isthmusectomy, 44 had near-total thyroidectomy and 318 a total thyroidectomy. For malignancy, patients received initial lobectomy (180) or total thyroidectomy (152). One hundred and eleven had completion surgery. Thirty patients had extensive surgery. Thyroid growth and function was investigated using 500 human thyroid cell primary cultures obtained at surgery, as well as in three animal models. The role of pituitary tumour transforming gene (PTTG), PTTG binding factor (PBF) and sodium iodide symporter (NIS) in thyroid cell function was then evaluated. Temporary and permanent recurrent laryngeal nerve palsy rates were 2.4% and 0.4%. Other complications included temporary (21%) and permanent (3%) hypoparathyroidism, wound infection (1.2%), haematoma (1.2%) and poor scar (0.8%). Six patients have died. Regarding thyroid growth and function, TSH represents (either directly or indirectly) the main factor mediating thyroid follicular cell growth. For carcinogenesis, over-expression of the proto-oncogenes PTTG and PBF induces tumours in nude mice, and PTTG can induce proliferation of human thyroid cells and, in addition, both repress expression and function of NIS.

US$19.90

PMID: 20883601

DOI: 10.1308/003588410X12699663905230


Other references

Hao, K.S., 1936: Plantae novae Sinicae. III. Two new grass species are included in the list, namely, Diarrhenia sinica Hao and Leersia sinensis Hao.

Conte B.; Kawatani M.; D.G.oat W.C., 1990: Electrophysiological evidence for the existence of branching efferent neurons innervating both the urinary bladder and the external urethral sphincter in rats. Neuroscience Letters Supplement (39): S58

Cankurtaran, E.Sahin.; Ozalp, E.; Soygur, H.; Cakir, A., 2006: Clinical experience with risperidone and memantine in the treatment of Huntington's disease. We described a 32-year-old woman with Huntington's disease (HID) who presented with severe chorea, psychosis and cognitive abnormalities. We started risperidone at 2 mg p.o./d and increased to 4 mg p.o./d after six weeks. Psychotic and motor...

Eliopoulos, G.M., 2006: Enterococci: on the back burner but still simmering. Current Infectious Disease Reports 8(5): 333-336

Wong, Y.Ching.; Teh, H.Fang.; Mebus, K.; Ooi, T.Eng.Keong.; Kwong, Q.Bin.; Koo, K.Loo.; Ong, C.Kee.; Mayes, S.; Chew, F.Tim.; Appleton, D.R.; Kulaveerasingam, H., 2017: Differential gene expression at different stages of mesocarp development in high- and low-yielding oil palm. The oil yield trait of oil palm is expected to involve multiple genes, environmental influences and interactions. Many of the underlying mechanisms that contribute to oil yield are still poorly understood. In this study, we used a microarray appro...

Hrabe, F.; Halva, E., 1987: Effect of long-term fertilizer application on grassland production in regions of the Bohemian-Moravian highlands with springs. In trials in 1974-84, the effects of application of 100 or 200 kg N/ha + PK to a natural Polygalo-Nardetum grassland gave av. yields of 5.12 and 7.13 t DM/ha, resp., compared with 1.67 t with no fertilizer. The natural grassland gave yields 25.4 a...

Levine, M.K., 1966: Anterior fontanel bone. A case of an anterior fontanel bone in an otherwise normal child demonstrates that early enlargement of the head may occur with an anterior fontanel bone. Repeated clinical examinations should be carried out in order to confirm the benign nature o...

Lauven, P.M.; Roeper, A., 1995: Basics of pharmacokinetics. Anaesthesist 44(9): 663-676

Kulasiri, C.; Seneviratne, R.D., 1956: Gigantocptyle explanation Creplin (Trematoda: Paramphistomidae) infection of the liver of the buffalo in Ceylon. Kulasiri & Seneviratne have stuthed the gross lesions and histopathology of the livers of buffaloes infected with Gigantocotyle explanation. Most of the paramphistpmes occurred in the bile-ducts although some were found in the liver substance and,...

Kovanova, E.N., 1964: Lysogeny of enteropatho-genic coliform bacilli and phage-typing of them Questions of the epidemiology, microbiology, and prevention of intestinal infections. Lysogeny of enteropatho-genic coliform bacilli and phage-typing of them Questions of the epidemiology, microbiology, and prevention of intestinal infections Lizogeniya enteropatogennykh kishechnykh palochek i ikh fagotipirovanie In: Voprosy epi-demiologii, mikrobiologii i profilaktiki kishechnykh infektsii Questions of the epidemiology, microbiology, and prevention of intestinal infections 189-190