+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Focal cerebral ischemia in rats alters APP processing and expression of Abeta peptide degrading enzymes in the thalamus

, : Focal cerebral ischemia in rats alters APP processing and expression of Abeta peptide degrading enzymes in the thalamus. Neurobiology of Disease 35(1): 103-113

We have previously demonstrated aggregation of amyloid precursor protein (APP) and beta-amyloid (Abeta) to dense plaque-like deposits in the thalamus of rats subjected to transient middle cerebral artery occlusion (MCAO). Here, we investigated the underlying molecular effects of MCAO on APP processing and expression profiles of Abeta degrading enzymes in the cortex adjacent to the infarct (penumbra) and ipsilateral thalamus 2, 7 and 30 days after ischemic insult. Enhanced beta-amyloidogenic processing of APP and altered insulin degrading enzyme and neprilysin expression were observed in the thalamus, but not the penumbral cortex, 7 and 30 days after MCAO coinciding with increased calcium levels and beta-secretase (BACE) activity. Consecutively, increased BACE activity associated with depletion of BACE trafficking protein GGA3, suggesting a post-translational stabilization of BACE. These results demonstrate that focal cerebral ischemia leads to complex pathogenic events in the thalamus long after the initial insult.


PMID: 19426802

DOI: 10.1016/j.nbd.2009.04.009

Other references

Mullin, P.A.; Herrmann, D.J.; Searleman, A., 1993: Forgotten variables in memory theory and research. Memory research, like other scientific research, disregards many variables in order to bring the full force of the scientific method to bear on clearly important variables. The reasons why memory research attends to certain variables and disregard...

Ivanovska, S.; Stojkovski, C.; Marinkovic, L., 2000: Inheritance mode and gene effect on spikelets number per spike in wheat. The inheritance of the trait spikelet number per spike was evaluated in the F1 and F2 generations of 7 x 7 half diallel crosses of wheat cultivars and lines. The inheritance mode (intermediate, dominant or overdominant), calculated for each combin...

Wagner, Y.N., 1930: Analytical keys for the deter-mination of Aphaniptera living on Muridae. Magazin de Parasitologie Leningrad, 1: 97-192

Phillips J.; Pyeritz R.; Brooks B.; Rosenthal G.; Weintraub A.; Weinblatt J., 1978: Familial amyotrophic lateral sclerosis an evaluation of genetic counseling. American Journal of Human Genetics 30(6): 63A

Grotkowski C.E.; Sears H.; Shen J W., 1990: Variable expression of tumor associated antigens in colon cells relation to staging differentiation and diagnosis. Moyer, M P And G H Poste (Ed ) Cell Biology Monographs: A Series Of Monographs: Colon Cancer Cells Xviii+554p Academic Press, Inc : San Diego, California, Usa; London, England, Uk Illus 475-496

Sabelis, M.; Afman, B.; Slim, P., 1984: Location of distant spider mite colonies by Phyto-seiulus persimilis: localization and extraction of a kairomone. Acarology VI editors DA Griffiths and CE Bowman: 440

Kao S.E.; Roefs T.G.; Ince S., 1975: Parameter influence on runoff modeling. Hydrology and Water Resources in Arizona and the Southwest: ges 29-33. 1975.

Lee, G.; Cho, Y-Jaung.; Park, B.Keun.; Lee, K.; Park, J.T., 2003: Two metal centers bridging two C60 cages as a wide passage for efficient interfullerene electronic interaction. The reaction of Ir4(CO)8(PMe3)4 with excess C60 in refluxing 1,2-dichlorobenzene, followed by treatment by CNR (R = CH2C6H5) at 70 degrees C, affords a fullerene-metal sandwich complex Ir4(CO)3(mu4-CH)(PMe3)2(mu-PMe2)(CNR)(mu-eta2,eta2-C60)(mu4-et...

Anonymous, 2012: Mount Sinai presents treatment trends, vaccine research, prognosis data at ASCO. Mount Sinai School of Medicine researchers will present several landmark studies, including data on treatment trends in late-stage cancer, a promising multiple myeloma vaccine, and predictive models of soft tissue sarcomas, prostate and bladder ca...

Rubie, H.; Juricic, M.; Claeyssens, S.; Krimou, A.; Lemozy, J.; Izard, P.; Guitard, J.; Ane, M.; Prere, M.F.; Fedacou, F., 1995: Morbidity using subcutaneous ports and efficacy of vancomycin flushing in cancer. An evaluation of totally implanted venous access systems inserted in 163 consecutive children with cancer is reported. From 1988 to 1994, 180 subcutaneous ports were inserted in children more than 1 year old. Initial diagnosis was acute leukaemia...