+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Four-year study of entecavir efficacy and safety in nucleos(t)ide-naïve HBeAg positive chronic hepatitis B patients

, : Four-year study of entecavir efficacy and safety in nucleos(t)ide-naïve HBeAg positive chronic hepatitis B patients. Acta Clinica Croatica 53(1): 31-36

Entecavir is a guanosine analogue with activity against hepatitis B virus. The aim of this 4-year trial was to evaluate entecavir treatment in nucleos(t)ide-naïve HBeAg-positive chronic hepatitis B patients. Forty-nine patients received entecavir and nine of them withdrew from the trial at the end of week 96. The initial mean value of alanine aminotransferase was 79.4 +/- 41.5 IU/L, and at the end of the 4-year study period, 90% of patients had alanine aminotransferase values within the normal range. At week 96, 91.7% of patients had HBV DNA < 300 copies; at month 48, 90% of patients had HBV DNA < 50 IU/mL. HBeAg loss was recorded in 7.1% of patients at week 96 and in 12.5% at month 48. The rate of HBeAg seroconversion was 4.8% at week 96 and 7.5% at month 48. The rate of HBsAg seroconversion was 2.1% at week 96 and 2.5% at month 48. Entecavir as a potent and safe agent leading to continuous viral suppression proved to be safe and well tolerated therapy.


PMID: 24974664

Other references

Van Zwieten L.; Ayres M.; Morris S., 2000: Intrinsic biodegradation of DDT in cattle dip soil; effects of arsenic co-contamination. Pages 375-382 2000

Beard, H.H.; Boggess, T.S., 1935: A comparison of the anemia produced by feeding young rats upon human, cow and goat milk. Weanling rats were used. The rate of growth was greatest in the human milk and lowest in the goat's milk group. Anaemia did not develop in the human milk group but was progressive in the others. The drop in red cells was much more rapid in th...

Hoh, J.F.; Hughes, S.; Hoy, J.F., 1988: Myogenic and neurogenic regulation of myosin gene expression in cat jaw-closing muscles regenerating in fast and slow limb muscle beds. Immunocytochemical techniques were used to study changes in myosin gene expression during the regeneration of the cat posterior temporalis muscle transplanted into the bed of either the fast extensor digitorum longus (EDL) or the slow soleus muscl...

Yildirim, M.; Hettiarachchy, N.S.; Kalapathy, U., 1996: Properties of biopolymers from cross-linking whey protein isolate and soybean 11S globulin. Biopolymers were prepared by cross-linking whey protein isolate (WPI) and soybean 11S using transglutaminase. Electrophoretic pattern, solubility, emulsification, hydrophobicity and foaming properties of the biopolymers were determined. SDS-PAGE s...

Chiabrando,V.; Giacalone,G., 2008: Studies on shelf life of lateblue highbush blueberries. There is a considerable scope to maintain the quality and extend shelf-life of perishable and soft fruits such as strawberries, raspberries, and blueberries by developing and evolving packaging strategies. In this work a study on the packaging of...

Albashaireh, Z.S.M.; Ghazal, M.; Kern, M., 2010: Two-body wear of different ceramic materials opposed to zirconia ceramic. Little is known about the wear behavior of ceramics opposed to unveneered zirconia and whether wear varies according to microstructure, surface toughness, and flexural strength of the ceramics. The purpose of this study was to evaluate the 2-body...

Sabalka, D., 1987: Propagation media for flats and for direct sticking: What works?. Combined proceedings International Plant Propagators' Society6(36): 409-413

Tainter, F.H.; O'brien, J.G.; Rebolledo, O.; Orozco, F.; Hernandez, A., 1998: Parota decline in Mexico. Phytopathology 88(9 SUPPL ): S88, Sept

Sieberg, C.B.; Flannery-Schroeder, E.; Plante, W., 2011: Children with co-morbid recurrent abdominal pain and anxiety disorders: results from a multiple-baseline intervention study. Recurrent Abdominal Pain (RAP), one of the most common complaints of childhood, is associated with many adverse outcomes. However, few treatment studies have been conducted, especially for children with co-morbid RAP and anxiety disorders. The pri...

Otto, S.R.; Brackman, D.E.; Hitselberger, W.E.; Shannon, R.V., 2001: Brainstem electronic implants for bilateral anacusis following surgical removal of cerebello pontine angle lesions. The multichannel auditory brainstem implant (ABI) has been used successfully to treat deafness in individuals with neurofibromatosis type II. The device has been implanted in nearly 150 recipients worldwide, and clinical trials with the device are...