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Fragment-based drug discovery


, : Fragment-based drug discovery. Journal of Computer-Aided Molecular Design 23(8): 453-458


US$19.90

PMID: 19554264

DOI: 10.1007/s10822-009-9292-1


Other references

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Brooks, J.W.; Robinett, P.; Largen, T.L.; Evans, E.I., 1951: A standard contact burn; method of production and observations on the blood picture following its production in dogs. Surgery, Gynecology & Obstetrics 93(5): 543-554

Jarman, P.R.; del Grosso, N.; Valente, E.M.; Leube, B.; Cassetta, E.; Bentivoglio, A.R.; Waddy, H.M.; Uitti, R.J.; Maraganore, D.M.; Albanese, A.; Frontali, M.; Auburger, G.; Bressman, S.B.; Wood, N.W.; Nygaard, T.G., 1999: Primary torsion dystonia: the search for genes is not over. A GAG deletion in the DYT1 gene accounts for most early, limb onset primary torsion dystonia (PTD). The genetic bases for the more common adult onset and focal PTD are less well delineated. Genetic loci for an "intermediate dystonia" phe...

Martyushov, V.M.; Aliev, A.A., 1987: Saturation and desaturation of fatty acids in the digestive tract and its wall in ruminants. The effect of pelleted feeds on hydrogenation of unsaturated fatty acids (FA) in the forestomachs of cattle was studied, as was the possibility of desaturation of saturated FA in the lumen, and of stearic acid in the wall of the forestomach of she...

Smith, R.C.; Mathur, C.F., 1973: Incorporation of adenine and uracil into the nucleic acids of Streptococcus bovis. Adenine-8-14C and uracil-2-14C were rapidly taken up and incorporated into the nucleic acids of Streptococcus bovis and mixed cultures of rumen bacteria. The radioactivity from adenine-8-14C was found in both the adenine and guanine of RNA and DNA...

Hagemann, I.S.; Cottrell, C.E.; Lockwood, C.M., 2014: Design of targeted, capture-based, next generation sequencing tests for precision cancer therapy. In cancer medicine, next generation sequencing (NGS) has emerged as a practical method to generate patient- and tumor-specific genetic data for optimal selection of targeted therapies. Targeted sequencing allows clinical testing to focus on cancer...

Escudero-Martinez, C.M.; Morris, J.A.; Hedley, P.E.; Bos, J.I.B., 2017: Barley transcriptome analyses upon interaction with different aphid species identify thionins contributing to resistance. Aphids are phloem-feeding insects that cause yield loss on a wide range of crops, including cereals such as barley. Whilst most aphid species are limited to one or few host species, some are able to reproduce on many plants belonging to different...

Sung, Z.R.; Okimoto, R., 1983: Coordinate gene expression during somatic embryogenesis in carrots. There are several biochemical differences between the callus and the embryos of carrot culture. Callus tissue produces callus-specific proteins and a conditioning factor that is necessary for the synthesis of callus-specific proteins. By contrast,...

Cheng K.N.; Dworzak F.; Ford G.C.; Rennie M.J.; Halliday D., 1985: Direct determination of leucine metabolism and protein breakdown in humans using l 1 carbon 13 nitrogen 15 leucine and the forearm model. We have used the forearm model to study protein metabolism in six normal healthy subjects in the fed state using L-[1-13C, 15N]-leucine as the substrate tracer. Deep venous and arterialized venous blood samples from the forearm were collected at 1...