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Functional classification of neurons in the mouse lateral cerebellar nuclei

, : Functional classification of neurons in the mouse lateral cerebellar nuclei. Cerebellum 10(4): 637-646

The deep cerebellar nuclei (DCN) are at the center of the cerebellum not only anatomically but also functionally. Classical anatomical studies have described different types of DCN neurons according to their expression of various marker proteins, but only recently have we begun to characterize these different cell types according to their electrophysiological properties. These efforts have benefited greatly from the availability of transgenic mouse lines that express green fluorescent protein under the control of the glutamic acid decarboxylase (GAD67) and glycine transporter (GlyT2) promoters, which are markers for GABAergic and glycinergic neurons, respectively. These studies have identified several types of neurons within the lateral cerebellar nuclei, each of which exhibits distinct active membrane properties. In addition to their differential use of neurotransmitters (glutamate, GABA, or glycine), these cell types also receive and provide synaptic information from different sources and to different targets.


PMID: 21116763

DOI: 10.1007/s12311-010-0240-3

Other references

Ayer, A.Ananthanarayana, 1941: Facial musculature of Semnopithecus en-tellus. Two specimens of S. entellus were dissected. The subcutaneous colli consists of well developed noto- and trachelo-platysmae and forms a nearly complete investment for the neck. The only gaps in this muscular investment are a small triangular inter...

Osawa H.; Diamantstein T., 1989: Studies on the formation of high affinity il 2 binding sites of an il 2 receptor p55 plus p75 heterodimeric complex functional importance of a determinant on the p55 subunit defined by a monoclonal antibody aht 107. The monoclonal antibody (mAb) AHT-107 recognized a determinant distal to the interleukin 2 (IL-2) binding site on the p55 subunit of the IL-2 receptor (IL-2R) (the Tac antigen, CD25) of human T lymphoblasts, while the mAb AHT-54 recognized a deter...

Manfredi, B.; Sacerdote, P.; Gaspani, L.; Poli, V.; Panerai, A.E., 1998: IL-6 knock-out mice show modified basal immune functions, but normal immune responses to stress. To better determine the role of interleukin-6 in the mechanisms that regulate stress-induced immunosuppression, we used in this study an interleukin-6-deficient mice model recently generated by gene targeting. We report here that, in basal conditi...

Dobzhansky, T.; Montagu, M.F., 1947: Natural Selection and the Mental Capacities of Mankind. There can be no genuine clarity in the understanding of man's biol. nature until the role of the social factor in his development is understood. For rational systems of evolution it is necessary to look to those which consider progressive ada...

Miller, Pe, 1976: Energy crisis--ways out. Minnesota science: er 77, 32 (4) 6-7

Jelenko C3rd; Smulyan, W.I.; Wheeler, M.L., 1968: Studies in burns: the role of lipids in the transmissivity of membranes. Annals of Surgery 167(4): 521-532

Gillikin David Paul; Kaczmar John William; Manzo Mitchell J.; Waines Russell H., 1994: Kame terrace sequence, northern Shawangunk Mountains; trans-glacier drainage, Wallkill Valley lobe, southeastern New York. Abstracts with Programs - Geological Society of America 26(3): 19

Xian, Xingfu, 1996: Effects of pH in polluted soils on the amount of heavy metals uptake by mulberry plant. Polluted soils collected from mulberry fields in Annaka City, Gunma Prefecture, were adjusted for the pH values from 4.5 to 6.9 and the effects of soil pH on the mulberry plant growth and the plant availability of Cd, Zn and Pb were investigated....

Izumi K., 1985: Mobility of large-scale avalanche. Niigata Daigaku Sekisetsu Chiiki Saigai Kenkyu Senta Kenkyu Nenpo = Annual Report of the Research Institute for Hazards in Snowy Area, Niigata University 7: 187-194

García-León, J.A.; López-Gómez, C.; Orpez-Zafra, T.; Reyes-Garrido, V.; Marín-Bañasco, C.; Oliver-Martos, Bña.; Fernández, O.; Leyva, L., 2015: Killer-cell immunoglobulin-like receptor expression on lymphocyte subsets in multiple sclerosis patients treated with interferon-β: evaluation as biomarkers for clinical response. Cns Drugs 28(6): 559-570