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Functional classification of neurons in the mouse lateral cerebellar nuclei


, : Functional classification of neurons in the mouse lateral cerebellar nuclei. Cerebellum 10(4): 637-646

The deep cerebellar nuclei (DCN) are at the center of the cerebellum not only anatomically but also functionally. Classical anatomical studies have described different types of DCN neurons according to their expression of various marker proteins, but only recently have we begun to characterize these different cell types according to their electrophysiological properties. These efforts have benefited greatly from the availability of transgenic mouse lines that express green fluorescent protein under the control of the glutamic acid decarboxylase (GAD67) and glycine transporter (GlyT2) promoters, which are markers for GABAergic and glycinergic neurons, respectively. These studies have identified several types of neurons within the lateral cerebellar nuclei, each of which exhibits distinct active membrane properties. In addition to their differential use of neurotransmitters (glutamate, GABA, or glycine), these cell types also receive and provide synaptic information from different sources and to different targets.

US$19.90

PMID: 21116763

DOI: 10.1007/s12311-010-0240-3


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