+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Functional roles for T cell CD40 in infection and autoimmune disease: the role of CD40 in lymphocyte homeostasis

, : Functional roles for T cell CD40 in infection and autoimmune disease: the role of CD40 in lymphocyte homeostasis. Seminars in Immunology 21(5): 283-288

CD40 stimulation on monocytes/macrophages, dendritic cells, and B-lymphocytes has been the subject of much study. It is well recognized that activation of CD40 on antigen presenting cells by its ligand, CD154, expressed on T-lymphocytes, contributes to the pro-inflammatory response necessary for eradication of infection, yet pathological in autoimmunity. However, there is evidence that CD40 is also expressed on T-lymphocytes and can act as a costimulatory molecule. While the exact role of CD40 on CD8 T cells remains controversial, it does appear to contribute to the adaptive immune response against infection. CD40 on CD4 T cells, on the other hand, plays a functional role in the autoimmune disease process. Further dissection of the exact nature and role of CD40 in T cell activation could lead the way to more effective vaccines and novel therapeutics for autoimmune diseases.


PMID: 19539498

DOI: 10.1016/j.smim.2009.05.008

Other references

Sidhu, K.S.; Balon, R.; Ajluni, V.; Boutros, N.N., 2009: Standard EEG and the difficult-to-assess mental status. Delirium commonly appears on the differential diagnostic list of psychiatric patients in acute care settings. When a patient is unable or unwilling to answer questions about orientation, determination of possible delirium or other probable etiolog...

Campkin, N.; Ooi, R.; Soni, N., 1992: Oxygen uptake during rebreathing in a mapleson A system. British Journal of Anaesthesia 69(5): 538P

Satao, R.N.; Nalamwar, R.W., 1991: Effect of herbicides and weeding on RGR, NAR and yield of sorghum. In field trials in 1987-88 the effects of 11 treatment combinations of herbicides (1.0 kg atrazine, 0.5 or 1.0 kg prometryn and 900 g 2,4-D (ethyl ester)/ha) applied pre-emergence or post-emergence, with or without weeding 30, 45 or 60 d after ger...

Greifzu, F.; Kalogeraki, E.; Löwel, S., 2016: Environmental enrichment preserved lifelong ocular dominance plasticity, but did not improve visual abilities. In standard cage (SC)-raised mice, ocular dominance (OD) plasticity of the primary visual cortex (V1) induced by monocular deprivation (MD) is maximal in juveniles, declines in adults, and is absent beyond postnatal day (PD) 110. Raising mice in a...

Deemagarn, T.; Wiseman, B.; Carpena, X.; Ivancich, A.; Fita, I.; Loewen, P.C., 2006: Two alternative substrate paths for compound I formation and reduction in catalase-peroxidase KatG from Burkholderia pseudomallei. Five residues in the multifunctional catalase-peroxidase KatG of Burkholderia pesudomallei are essential for catalase, but not peroxidase, activity. Asp141 is the only one of these catalase-specific residues not related with the covalent adduct f...

True, A.C., 1899: The Association Of American Agricultural Colleges And Experiment Stations. Science 10(239): 110-113

Harris, L.E.; Bassett, C.F.; Llewellyn, L.M.; Loosli, J.K., 1951: The protein requirement of growing foxes. A total of 248 foxes was used to determine the protein requirements of young foxes from 50 to 161 days of age and from 162 to 259 days of age. Protein was fed at 14.1, 16.9, 19.1, 22.5, 24.5, 28.0, 33.8, and 39.6% levels in the dry diet. Control f...

Morgane, P.J., 1963: Prevention of cholinergic induced sleep following lesions in medial forebrain bundle. FED PROC 22(2 Pt 1): 638

Gracioli, L.F.; Brag, M.R.B.; Moraes, R.L.M.S. de, 2003: Electrophoretical protein profile in Apis mellifera (Hymenoptera; Apidae) hypopharyngeal glands under juvenile hormone effect when the colony is grown in the absence of brood. Twelve-day-old and 25-day-old Apis mellifera workers were treated or not treated with juvenile hormone at the moment of emergence and reared in the colony without brood. Having the brood interference apart, the hormone effect on the hypopharyngeal...

Grava, C., 1968: Some aspects of the personality in alcoholics. Il Friuli Medico 23(6): 1019-1026