+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Gene Polymorphisms of ADIPOQ +45T>G, UCP2 -866G>A, and FABP2 Ala54Thr on the Risk of Colorectal Cancer: A Matched Case-Control Study

, : Gene Polymorphisms of ADIPOQ +45T>G, UCP2 -866G>A, and FABP2 Ala54Thr on the Risk of Colorectal Cancer: A Matched Case-Control Study. Plos One 8(6): E67275-E67275

As insulin resistance (IR) is an established risk factor for colorectal cancer (CRC), we explored the association between each of the IR-related gene polymorphisms of adiponectin (ADIPOQ) rs2241766, uncoupling protein 2 (UCP2) rs659366, and fatty acid-binding protein (FABP2) rs1799883 and CRC risk. Genotyping of blood samples and collection of lifestyle and dietary habits were performed for 400 case-control pairs. Unconditional logistic regression (ULR) was applied to assess the effects of the three single nucleotide polymorphisms (SNP), environmental factors. Both ULR and generalized multifactor dimensionality reduction (GMDR) were used to test the gene-gene and gene-environment interactions on CRC risk. Subjects carrying the ADIPOQ rs2241766 TG+GG genotype had a higher CRC risk than those carrying the TT genotype (OR = 1.429, 95% CI 1.069-1.909). The additive and multiplicative interactions between ADIPOQ rs2241766 and FABP2 rs1799883 on CRC were found by ULR (RERI = 0.764, 95%CI 0.218∼1.311, AP = 0.514, 95%CI 0.165∼0.864, S = -1.745, 95%CI is unachievable, and Pmulti = 0.017, respectively). Furthermore, the high order gene-gene interaction of the three SNPs were found by GMDR (P = 0.0107). A significant dosage effect with an increasing number of risk genotypes was observed as the risk of CRC increased (Ptrend = 0.037). In GMDR, the gene-environment interaction among the three SNPs and red meat consumption on CRC risk was significant (P = 0.0107). Compared with subjects with low red meat consumption and null risk genotypes, those with high-red meat consumption and three risk genotypes had 3.439-fold CRC risk (95% CI 1.410-8.385). In conclusion, the results showed that the ADIPOQ rs2241766 TG+GG genotype increased CRC risk. Given the complexity of the carcinogen for CRC, ADIPOQ rs2241766, UCP2 rs659366, FABP2 rs1799883 and red meat consumption potentially worked together in affecting CRC risk.


PMID: 23826253

DOI: 10.1371/journal.pone.0067275

Other references

Reed, M.J.; Steeves, J.K.E.; Steinbach, M.J.; Kraft, S.; Gallie, B., 1996: Contrast letter thresholds in the non-affected eye of strabismic and unilateral eye enucleated subjects. To investigate the effects of visual disruption on contrast letter thresholds of the non-affected eye, subjects with one eye enucleated, strabismic subjects using the non-deviating eye and normal control subjects were asked to identify letters on...

Lee, A.; Crowther, M., 2011: Practical issues with vitamin K antagonists: elevated INRs, low time-in-therapeutic range, and warfarin failure. Millions of patients worldwide are prescribed vitamin K antagonists for a variety of medical conditions annually. Despite widespread and long-standing experience with these medications, medical care providers are often confronted with challenging...

Worthington, J.; Day, R.A.lenbach, B., 1977: A rapid, accurate, pictorial technique for continual assessment of tomato ripening behavior in commercial volume. Acta Horticulturae 62: 51-361

Stenger, J., 2011: Reduction in disability living allowance. Mental Health Today: 20-20

Londowski, J.M.; Kost, S.B.; Meier, W.; Labler, L.; Kumar, R., 1986: Biological activity of the C-1, C-3, C-25, beta-D-glucopyranosides of 1,25-dihydroxyvitamin D3. We have shown previously that the 3-beta-D-glucopyranosides of vitamin D3, 1 alpha-hydroxyvitamin D3, 1,25-dihydroxyvitamin D3 and 25-hydroxyvitamin D3 are biologically active in vivo. In order to determine whether the presence of the beta-D-gluco...

Sheldon, K.S.; Greeney, H.F., 2008: Comparison of parental care of the great antshrike Taraba major in Costa Rica and Ecuador. Ornitologia Neotropical 19(2): 293-297

Carlough L.A., 1989: Fluctuations in the community composition of water column protozoa in two southeastern blackwater rivers georgia usa. This study addresses protozoan population dynamics of two southeastern blackwater rivers in Georgia: the sixth order Ogeechee River and fourth order Black Creek. The density and composition of the protozoan community was assessed by counting the p...

Mousa, A.; Faries, P.L.; Bernheim, J.; Dayal, R.; DeRubertis, B.; Hollenbeck, S.; Henderson, P.; Mahanor, E.A.; Kent, K.Craig., 2004: Rupture of excluded popliteal artery aneurysm: implications for type II endoleaks--a case report. The fate of popliteal artery aneurysms after ligation and bypass is believed to be relatively innocuous. The patient presented in this report, however, experienced spontaneous rupture of a popliteal aneurysm 11 years after ligation and bypass. Mag...

Hoette, M., 2004: Amur leopard conservation project Neues vom Amur-Leoparden-Schutzprojekt. Amur leopard conservation update The second camera-trapping survey during the 2003/2004 winter season in the Amur leopard range in Southwest Primorye identified a total of 13 different individual leopards, whereas only ten individuals were identif...

Tani, K.; Shibata, M.; Kawase, K.; Kawashima, H.; Hatsuzawa, K.; Nagahama, M.; Tagaya, M., 2003: Mapping of functional domains of gamma-SNAP. gamma-Soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (gamma-SNAP) is capable of stabilizing a 20 S complex consisting of NSF, alpha-SNAP, and SNAP receptors (SNAREs), but its function in vesicular transport is not fully underst...