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Gene expression variability in human hepatic drug metabolizing enzymes and transporters

, : Gene expression variability in human hepatic drug metabolizing enzymes and transporters. Plos One 8(4): E60368-E60368

Interindividual variability in the expression of drug-metabolizing enzymes and transporters (DMETs) in human liver may contribute to interindividual differences in drug efficacy and adverse reactions. Published studies that analyzed variability in the expression of DMET genes were limited by sample sizes and the number of genes profiled. We systematically analyzed the expression of 374 DMETs from a microarray data set consisting of gene expression profiles derived from 427 human liver samples. The standard deviation of interindividual expression for DMET genes was much higher than that for non-DMET genes. The 20 DMET genes with the largest variability in the expression provided examples of the interindividual variation. Gene expression data were also analyzed using network analysis methods, which delineates the similarities of biological functionalities and regulation mechanisms for these highly variable DMET genes. Expression variability of human hepatic DMET genes may affect drug-gene interactions and disease susceptibility, with concomitant clinical implications.


PMID: 23637747

DOI: 10.1371/journal.pone.0060368

Other references

Switzer, B.W., 1866: Observations on the Pathology and Treatment of Cholera. Indian Medical Gazette 1(2): 26-28

Edler L.; Thielmann H.W., 1987: Analysis of colony forming ability of human fibroblast strains by linear regression. A linear regression approach is presented for the statistical analysis of dose-response curves obtained by measuring the colony-forming ability of human fibroblast strains. The crucial determination of the dose range in which the linear model can...

Patsavoudi, E.; Magre, S.; Castanier, M.; Scholler, R.; Jost, A., 1985: Dissociation between testicular morphogenesis and functional differentiation of Leydig cells. The aim of the study was to determine whether Leydig cells differentiate in vitro in gonads in which the formation of seminiferous cords is prevented by culture in a medium containing fetal calf serum. Appearance of 3 beta-hydroxysteroid dehydroge...

Song, Y.; Sonawane, N.D.; Salinas, D.; Qian, L.; Pedemonte, N.; Galietta, L.J.V.; Verkman, A.S., 2004: Evidence against the rescue of defective DeltaF508-CFTR cellular processing by curcumin in cell culture and mouse models. Curcumin, the yellow colored component of the spice turmeric, has been reported to rescue defective DeltaF508-cystic fibrosis transmembrane conductance regulator (CFTR) cellular processing in homozygous mutant mice, restoring nasal potential diffe...

Kecan, V.D.; Martinze, G.C.rzo, P., 1977: Development of an accelerated system of propagation of potato plants free of virus and other pathogens. Informe del Programa Nacional de Fisiologia Vegetal: 149-153

Jin, C., 1992: Affinities of PBPs of enterococci to cefepime and ampicillin. The .beta.-lactam resistance of genus Streptococcus has been explained by the low binding affinity of penicillin-binding proteins (PBPs) to the drug. This study was carried out to resolve the mechanisms of resistance to .beta.-lactam antibiotics i...

Nyulasz-Hank, J., 1975: Determination of the moisture content in quick-frozen mushed chestnuts. Hutoipar t 22 (3) 82-87

Alekseenko, A.V.; Stoliar, V.F.; Gordienko, I.I.; Simenovich, V.E.; Koval', O.V., 1990: Leiomyosarcoma of the lung. Klinicheskaia Khirurgiia: 60-60

Shinkarev, V.P.; Wraight, C.A., 1993: Kinetic factors in the bicycle model of oxygen evolution by Photosystem II. Flash-induced oxygen evolution and many related processes in thylakoids of oxygenic organisms are modulated with period four by the S-state transitions associated with the oxygen evolving system of Photosystem II (PS II). To analyze these phenomen...

Sanders, C.J., 1970: The distribution of carpenter ant colonies in the Spruce-Fir forests of northwestern Ontario. Colonies and underground tunnel systems of Camponotus herculeanus, C. noveboracensis and C. pennsylvanicus were mapped in three 1-acre plots in immature, intermediate, and overmature stands. Tunnelling in the forest floor occupied approximately 90...