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Genetic variants of the cytochrome P450 and glutathione S-transferase associated with risk of bladder cancer in a south-eastern Chinese population


, : Genetic variants of the cytochrome P450 and glutathione S-transferase associated with risk of bladder cancer in a south-eastern Chinese population. International Journal of Urology 15(3): 216-221

To evaluate the association between genetic polymorphisms of CYP2E1 RsaI and GSTM1 and development of bladder cancer in a south-eastern Han Chinese population. We hypothesized that the CYP2E1-1019T>A and GSTM1 polymorphisms were associated with risk of bladder cancer. In a hospital-based case-control study of 202 case patients with newly diagnosed bladder transitional cell carcinoma and 272 cancer-free controls frequency-matched by the age and sex, we genotyped these two polymorphisms using a polymerase chain reaction-restriction fragment length polymorphism method. We found that the GSTM1 null genotype was associated with an increased risk of bladder cancer (adjusted odds ratio [OR] = 1.73, 95% confidence interval [CI] = 1.17-2.56) compared with those with the non-null genotype, but the CYP2E1-1019T>A polymorphisms did not show any association. In the stratification analysis of the GSTM1 polymorphism, we found that the increased risk was more pronounced among subgroups aged < or =60 years (OR = 2.02, 95% CI = 1.08-3.77), smokers (OR = 1.94, 95% CI = 1.11-3.38) and non-drinkers (OR = 3.86, 95% CI = 1.28-11.60). GSTM1 polymorphism (but not CYP2E1 RsaI polymorphism) appears to contribute to the etiology of bladder cancer in a south-eastern Chinese population.

US$19.90

PMID: 18304215

DOI: 10.1111/j.1442-2042.2007.01915.x


Other references

Chaparro, J.; Rojas, M.O.; Wasserman, M., 2002: Plasmodium falciparum: underestimation of dihydrofolate reductase and dihydropteroate synthase polymorphism in field samples: a technical shortcoming of nested PCR assays with mutation-specific primers. In a study parallel to the present one, we conducted a genotype characterization of Plasmodium falciparum based on isolates of patients infected with malaria, who come from a small location in Colombia. The analysis involved extraction of DNA from...

Rosenblatt, R.A.; Gaponoff, M., 1984: The microcomputer as a vehicle for continuing medical education. Journal of Family Practice 18(4): 629-632

Takeuchi, K.; Ueshima, K.; Hironaka, Y.; Fujioka, Y.; Matsumoto, J.; Okabe, S., 1991: Oxygen free radicals and lipid peroxidation in the pathogenesis of gastric mucosal lesions induced by indomethacin in rats. Relation to gastric hypermotility. The relationship of gastric hypermotility to mucosal hemodynamics, lipid peroxidation and vascular permeability changes was investigated in the pathogenesis of indomethacin-induced gastric lesions in rats. Subcutaneous administration of indomethac...

Naik, S.K.; Knight, A.; Elliott, M.J., 1991: A successful modification of ultrafiltration for cardiopulmonary bypass in children. Total body water (TBW) is increased after cardiopulmonary bypass (CPB) resulting in tissue oedema and organ dysfunction. Ultrafiltration has been used to reduce this accumulation of water, although conventional ultrafiltration seemed ineffective i...

Essink K.; Bos A.H., 1985: Growth of three bivalve mollusks transplanted along the axis of the ems estuary west germany the netherlands. Young specimens of Mya arenaria, Mytilus edulis and Cerastoderma edule were transplanted at the start of the growing season from the Wadden Sea to 5 sites in the Ems estuary. Changes in shell lengths and weights of the soft parts were determined b...

Schierl, R.; Rohrer, B.; Hohnloser, J., 1995: Long-term platinum excretion in patients treated with cisplatin. The purpose of this study was to determine long-term renal platinum excretion after chemotherapy with cisplatin. We examined urinary platinum concentrations in 23 men at 150-3022 days after anticancer treatment for testicular neoplasm. Spot urine...

Fu, G.; Melville, S.E., 2002: Polymorphism in the subtelomeric regions of chromosomes of Kinetoplastida. Leishmania spp. and the related kinetoplastid Trypanosoma brucei are single-celled parasites. In Leishmania, the nuclear genome comprises 36 diploid chromosomes and occasional amplified minichromosomes, while the T. brucei nucleus contains 11 larg...

Spetsov, P.; Milkova, V.; Ivanov, P.; Ivanova, I.; Petrova, N.; Alexandrova, N.; Marinova, E., 1998: Transfer of powdery mildew resistance from tetraploid U genome carrier Aegilops species into bread wheat. This paper outlines progress in obtaining disomic addition, substitution and translocation lines, resistant to powdery mildew [Erysiphe graminis], from crosses between Bulgarian winter wheat varieties and tetraploid A. variabilis, A. kotschyi and...

Pineau, T.; Costet, P.; Puel, O.; Pfohl-Leszkowicz, A.; Lesca, P.; Alvinerie, M.; Galtier, P., 1999: Knockout animals in toxicology: assessment of toxin bioactivation pathways using mice deficient in xenobiotic metabolizing enzymes. Genetically engineered animal models represent a substantial improvement in in vivo assessment of toxic pathways. Several transgenic mouse lines have been designed to detect specific toxic markers in response to xenobiotic exposure. They are suita...

Serkedjieva, J.; Ivancheva, S., 2003: Biologically active constituents of a polyphenol extract from Geranium sanguineum L with anti-influenza virus activity. Antiviral Research 57(3): A82, February