+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Ghrelin: central and peripheral implications in anorexia nervosa

, : Ghrelin: central and peripheral implications in anorexia nervosa. Frontiers in Endocrinology 4: 15-15

Increasing clinical and therapeutic interest in the neurobiology of eating disorders reflects their dramatic impact on health. Chronic food restriction resulting in severe weight loss is a major symptom described in restrictive anorexia nervosa (AN) patients, and they also suffer from metabolic disturbances, infertility, osteopenia, and osteoporosis. Restrictive AN, mostly observed in young women, is the third largest cause of chronic illness in teenagers of industrialized countries. From a neurobiological perspective, AN-linked behaviors can be considered an adaptation that permits the endurance of reduced energy supply, involving central and/or peripheral reprograming. The severe weight loss observed in AN patients is accompanied by significant changes in hormones involved in energy balance, feeding behavior, and bone formation, all of which can be replicated in animals models. Increasing evidence suggests that AN could be an addictive behavior disorder, potentially linking defects in the reward mechanism with suppressed food intake, heightened physical activity, and mood disorder. Surprisingly, the plasma levels of ghrelin, an orexigenic hormone that drives food-motivated behavior, are increased. This increase in plasma ghrelin levels seems paradoxical in light of the restrained eating adopted by AN patients, and may rather result from an adaptation to the disease. The aim of this review is to describe the role played by ghrelin in AN focusing on its central vs. peripheral actions. In AN patients and in rodent AN models, chronic food restriction induces profound alterations in the « ghrelin » signaling that leads to the development of inappropriate behaviors like hyperactivity or addiction to food starvation and therefore a greater depletion in energy reserves. The question of a transient insensitivity to ghrelin and/or a potential metabolic reprograming is discussed in regard of new clinical treatments currently investigated.


PMID: 23549309

DOI: 10.3389/fendo.2013.00015

Other references

von Borell, E.; Baumgartner, J.; Giersing, M.; Jäggin, N.; Prunier, A.; Tuyttens, F.A.M.; Edwards, S.A., 2009: Animal welfare implications of surgical castration and its alternatives in pigs. This paper constitutes a review on the welfare aspects of piglet castration that considers the scientific literature published after 2004. Castrating during the neonatal period (1 to 3 days of age) is clearly painful. In addition, inflammatory pro...

Harris, M.B., 1989: Osteosarcoma--is there a role for oral low-dose methotrexate. Cancer Investigation 7(4): 357-360

Bouamaied, I.; Constable, E.C.; Housecroft, C.E.; Neuburger, M.; Zampese, J.A., 2012: Stereochemistry controlled by an asymmetric sulfur atom, and a rare example of a kryptoracemate. The ligands 4-methylthio-6-phenyl-2,2'-bipyridine (1) and the corresponding sulfoxide (2) and sulfone (3) have been synthesized and characterized in solution, and in the solid state by single crystal X-ray diffraction. Compounds 2 and 3 cryst...

Baker E.W.; Palmer S.E.; Huang W.Y., 1978: Early and intermediate chlorophyll diagenesis of Black Sea sediments; sites 379, 380, and 381. Initial Reports of the Deep Sea Drilling Project: art 2; Pages 707-715. 1978.

Shrimpton A.E.; Vijayalaxmi; Evans H.J., 1989: Dominantly inherited spinocerebellar ataxia sca1 linkage studies. Cytogenetics & Cell Genetics 51(1-4): 1080

Rosokha, S.V.; Kochi, J.K., 2002: Novel arene receptors as nitric oxide (NO) sensors. Nitric oxide sensors are based on the reversible, specific, and efficient binding to various types of arene receptors via intermolecular complexes, which are characterized by complete electron delocalization and strong interaction between the dono...

Batianoff, G.; Burrows, W., 1973: Studies in the dynamics and control of woody weeds in semi-arid Queensland. 2. cassia nemophila and Cassia artemisioides. Queensland journal of agricultural and animal sciences: 30 (1) 65-71

Emanuele, E.; Boso, M.; Brondino, N.; Pietra, S.; Barale, F.; Ucelli di Nemi, S.; Politi, P., 2010: Increased serum levels of high mobility group box 1 protein in patients with autistic disorder. High mobility group box 1 (HMGB1) is a highly conserved, ubiquitous protein that functions as an activator for inducing the immune response and can be released from neurons after glutamate excitotoxicity. The objective of the present study was to...

Bristowe, W.S., 1931: The Spiders of the Orkney and Shetland Islands. Proceedings of the Zoological Society of London Part 3: 951-956

Feria-Ortiz, M.; Garcia-Vazquez Uri Omar, 2012: A new species of Plestiodon Squamata Scincidae from Sierra Madre del Sur of Guerrero, Mexico. We describe a new species of lizard of the genus Plestiodon from the Sierra Madre del Sur of Guerrero, Mexico. Plestiodon nietoi sp. nov. shares a characteristic with all members of the P. brevirostris group in that the scale that medially borders...