geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Giant teratoma of the umbilical cord associated with foetal malformations: a morphological and cytogenetic study


, : Giant teratoma of the umbilical cord associated with foetal malformations: a morphological and cytogenetic study. Annales de Pathologie 33(1): 57-61

We report on an unusually large teratoma of the umbilical cord associated with multiple fetal anomalies. At 18 WG, an umbilical cord tumour was discovered by ultrasonography in a 38 year-old woman. A 2680 g female neonate (46, XX) was delivered at 37 WG by caesarean section. During surgery for exomphalos, a complete bowel malrotation, ischemic jejunal stenoses and bowel duplication were discovered. The tumor (2515 g) was a teratoma supplied by collaterals of the umbilical vein. Proliferative index calculated by flow cytometry was less than 10%. Tumor karyotype revealed several numerical anomalies with no structural abnormalities using multi-FISH analysis. Immunostaining for CEA and AFP were observed in endodermic derivatives of the duplication and associated with transient high levels of AFP in the blood. To our knowledge, it is the first case to be reported in the literature where karyotype, multi-FISH and FCM studies were available.

US$19.90

PMID: 23472897

DOI: 10.1016/j.annpat.2012.12.002


Other references

Matsuo, Y., 1971: Gastrin and secretion producing tumors. Nihon Rinsho. Japanese Journal of Clinical Medicine 29(10): 2248-2255

Sillard, R.; Agerberth, B.; Mutt, V.; Jörnvall, H., 1989: Sheep neuropeptide Y. A third structural type of a highly conserved peptide. Mammalian forms of neuropeptide Y (NPY) for which the amino acid sequences have previously been determined, are the human, pig, ox, rabbit, rat, and guinea-pig polypeptides. The only difference among these forms is at position 17, where pig and ox...

Hernández, Jé.V.; Osborn, F.; Herrera, B.; Liendo-Barandiaran, C.V.; Perozo, Jé.; Velásquez, D., 2009: Larvae-pupae parasitoids of Hylesia metabus Cramer (Lepidoptera: Saturniidae) in northeastern Venezuela: a case of natural biological control. The moth Hylesia metabus Cramer is considered a public health pest due to the release of urticating hairs by adult females during periodic invasions of towns and villages, producing dermatits in humans. We reported natural parasitism levels for th...

Hokken A.; Wolff E.; D.J.ng M.; Donckerwolcke R.; Abbad N.; Drop S.; Keizer S.D.; Wit J.; Gons M.; Otten B., 1990: A placebo controlled double blind trial of growth hormone treatment in children with chronic renal insufficiency. Pediatric Nephrology 4(5): C41

Handa, Y.; Yasuda, Y.; Abe, S., 2002: Scabies in Ryukyu wild boars on Amami-Oshima island. In recent years, skin disease with generalized alopecia or marked lichenification has been observed in Ryukyu wild boars (Sus scrofa riukiuanus) from Amami-Oshima island. Sarcoptic mange mites (Sarcoptes scabiei) have been detected from skin lesio...

Hanash, K.A.; Bissada, N.K.; Lewall, D.B.; Godwin, J.T., 1982: Genito-urinary schistosomiasis (bilharziasis). Part 3: endoscopic and pathologic diagnosis. Endoscopic findings in the acute and chronic stages of genito-urinary schistosomiasis are described and are related to histological vesical changes. The pathology induced by schistosome ova in the bladder is described and illustrated.

Pontes, R.J., 1990: Measles in rural workers: a methodological essay in social epidemiology. The study of a measles epidemic in the Ribeirão Preto region, in 1984, showed a high proportion of cases occurring among people above 15 years of age. This finding led to the identification of a particular characteristic of the disease's dis...

Zhang C.; L.Y.; Huang S., 1991: The effect of cold on physiological characteristics of the rat pulmonary circuit and a study of pathway for regulation of blood flow in circulation. Cryobiology 28(6): 557-558

Pawlicki, T.; Kim, G-Ya.; Hsu, A.; Cotrutz, C.; Boyer, A.L.; Xing, L.; King, C.R.; Luxton, G., 2007: Investigation of linac-based image-guided hypofractionated prostate radiotherapy. A hypofractionation treatment protocol for prostate cancer was initiated in our department in December 2003. The treatment regimen consists of a total dose of 36.25 Gy delivered at 7.25 Gy per fraction over 10 days. We discuss the rationale for su...

Fox, E.T., 1996: IV hydration in the terminally ill: ritual or therapy?. The management of dehydration is both a clinical and an ethical problem. Artificial hydration may increase pharyngeal and pulmonary secretions, which causes a choking sensation, nausea and vomiting. Food and fluid have a strong social, cultural, r...