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Glutamine and leucine provide enhanced protective immunity against mucosal infection with herpes simplex virus type 1

, : Glutamine and leucine provide enhanced protective immunity against mucosal infection with herpes simplex virus type 1. Immune Network 12(5): 196-206

Besides their role as building blocks of protein, there are growing evidences that some amino acids have roles in regulating key metabolic pathways that are necessary for maintenance, growth, reproduction, and immunity. Here, we evaluated the modulatory functions of several amino acids in protective immunity against mucosal infection of herpes simplex virus type 1 (HSV-1). We found that glutamine (Gln) and leucine (Leu) showed enhanced protective immunity to HSV-1 mucosal infection when two administration of Gln and single administration of Leu per day, but not when administered in combinations. Ameliorated clinical signs of HSV-1 challenged mice by the intraperitoneal administration of Gln and Leu were closely associated with viral burden and IFN-γ production in the vaginal tract at 2 and 4 days post-infection. In addition, the enhanced production of vaginal IFN-γ appeared to be caused by NK and HSV-1 antigen-specific Th1-type CD4+ T cells recruited into vaginal tract of mice treated with Gln and Leu, which indicates that IFN-γ, produced by NK and Th1-type CD4+ T cells, may be critical to control the outcome of diseases caused by HSV-1 mucosal infection. Collectively, our results indicate that intraperitoneal administration of Gln and Leu following HSV-1 mucosal infection could provide beneficial effects for the modulation of protective immunity, but dosage and frequency of administration should be carefully considered, because higher frequency and overdose of Gln and Leu, or their combined treatment, showed detrimental effects to protective immunity.


PMID: 23213313

DOI: 10.4110/in.2012.12.5.196

Other references

Pike, M.C.; Bernstein, L.; Peters, R.K., 1992: Re: Dietary fat and postmenopausal breast cancer. Journal of the National Cancer Institute 84(21): 1666-1669

Zhenhua Zhao; Nansheng Chen; Zhensheng Dong; Zhixin Qian, 1984: REE geochemistry of Ordovician-Tertiary strata in Nyalam-Gamba area, South Xizang (Tibet). Chinese Journal of Geochemistry 3(3): 220-234

Ruegemer, J.Jeffrey; Ho, S.N.; Augustine, J.A., 1990: Regulatory effects of transforming growth factor-b on IL-2- and IL-4-dependent T cell-cycle progression. Journal of Immunology 144: 67-76

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Dent C.M.; Graham G.P.; Fairclough J.A., 1991: A solution for arthroscope misting. A prospective study was undertaken to compare the incidence of arthroscope eyepiece misting in two groups of patients. In one group the irrigation fluid was at room tempature and in the other group the fluid was warmed to body temperature. Arthros...

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