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Glutathione transferases: a structural perspective

, : Glutathione transferases: a structural perspective. Drug Metabolism Reviews 43(2): 138-151

The glutathione transferases (GSTs) are one of the most important families of detoxifying enzymes in nature. The classic activity of the GSTs is conjugation of compounds with electrophilic centers to the tripeptide glutathione (GSH), but many other activities are now associated with GSTs, including steroid and leukotriene biosynthesis, peroxide degradation, double-bond cis-trans isomerization, dehydroascorbate reduction, Michael addition, and noncatalytic "ligandin" activity (ligand binding and transport). Since the first GST structure was determined in 1991, there has been an explosion in structural data across GSTs of all three families: the cytosolic GSTs, the mitochondrial GSTs, and the membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG family). In this review, the major insights into GST structure and function will be discussed.


PMID: 21428697

DOI: 10.3109/03602532.2011.558093

Other references

Benaglia, L.; Candotti, G.; Busnelli, A.; Paffoni, A.; Vercellini, P.; Somigliana, E., 2015: Antral follicle count as a predictor of ovarian responsiveness in women with endometriomas or with a history of surgery for endometriomas. To evaluate the accuracy of antral follicular count (AFC) in predicting ovarian responsiveness in ovaries with endometriomas or with a past history of surgical excision of endometriomas. Retrospective review. Academic hospital. Eighty-three women...

Choi, Y.Jung.; Park, H.; Lee, J.Sung.; Lee, J-Yeon.; Kim, S.; Kim, T.Won.; Park, J.Sun.; Kim, J.Eun.; Yoon, D.Hyun.; Suh, C., 2016: Methotrexate elimination and toxicity: MTHFR 677C>T polymorphism in patients with primary CNS lymphoma treated with high-dose methotrexate. NlmCategory="UNASSIGNED">The genetic association of the methylenetetrahydrofolate reductase gene (MTHFR) 677C>T polymorphism with methotrexate (MTX)-associated toxicity has been evaluated and conflicting results have been reported....

Preiss, J., 1933: Hadena illyria Frr. in Mitteldeuschland und ihre oekologische Beurteilung. Internationale Entomologische Zeitschrift Guben, 27: 73-79

Wang, J.; Lin, Q.; Fang, L.; Willis, W.D., 2003: Identification of types of nerve fibers that convey dorsal root reflexes. We have previously recorded antidromic activity driven by dorsal root reflexes (DRRs) from cut single dorsal root filaments in anesthetized rats using nerve conduction velocity to identify the fiber types. However, an argument has been raised abou...

Dausset, J.; Rapaport, F.T.; Legrand, L.; Colombani, J.; Barge, A.; Feingold, N., 1969: Studies on transplantation antigens (HL-A) by means of skin grafts from 90 children onto their fathers. Nouvelle Revue Francaise D'hematologie 9(2): 215-229

Anonymous, 1973: Society of Forensic Sciences establishes 1st section. Journal of the Canadian Dental Association 39(3): 154-154

Shams, KM., 1985: Occurrence and distribution of bustards in Baluchistan. Bustard Studies, 51-53 No. 3

Kovar, J.; Barber, S., 1990: Potassium supply characteristics of thirty-three soils as influenced by seven rates of potassium. Limited information is available on the effect of applications of multielement fertilizer materials on the concurrent changes in Kl (soil-solution K) and Ks (exchangeable K). The objectives of this research were to: (i) investigate the relative in...

Caraway B.H.; Krieg N.R., 1971: Reversal of flagellar uncoordination in spirillum volutans. Bacteriological Proceedings 71: 28

Gilot, B.L.forge, M.; Cabassu, J.; Romani, M., 1992: Ecological cartography of populations of the Rhipicephalus sanguineus group (Acari, Ixodoidea) in the Marseille population center in relation to different forms of town planning. Acarologia 33(1): 17-33