+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Glycans in melanoma screening. Part 1. The role of β1,6-branched N-linked oligosaccharides in melanoma

, : Glycans in melanoma screening. Part 1. The role of β1,6-branched N-linked oligosaccharides in melanoma. Biochemical Society Transactions 39(1): 370-373

Melanoma, which is one of the most aggressive human tumours, originates from melanin-producing melanocytes. As no effective systemic therapy exists for advanced-stage melanoma, the best chance of recovery remains surgical removal of thin early-stage melanoma. Aberrant glycosylation is a hallmark of malignancy and a well-studied class of β1,6-branched oligosaccharides is associated with malignant transformation of rodent and human cells, and poor prognosis in cancer patients. It is evident that increased β1,6 branching significantly contributes to the phenotype of melanoma cells, influencing the adhesion to extracellular matrix components and motility as well as invasive and metastatic potential. Despite the considerable success in establishing the role of β1,6-branched N-linked oligosaccharides in melanoma biology, there is virtually no progress in using these glycans as a screening tool for the early diagnosis of the disease, or a target-specific therapeutic agent.


PMID: 21265806

DOI: 10.1042/BST0390370

Other references

Anonymous, 1987: A systematic key to the tribes and genera of subfam. Bambusoideae (Gramineae) occurring in China and its neighbourhood. Journal of Bamboo Research 6(3): 13-28

Okoegwale, E.E.; Idialu, J.E., 1998: Trends in histomorphological features of leguminous woods in rain forest and derived savanna areas of Edo state, Nigeria. Comparative studies were carried out on fibre and vessel element characteristics in twenty-two leguminous woody plants in Edo State, Nigeria. All the species possess medium fibre length of between 900-1600 mum except in Acacia nilotica, Dialium gu...

Puglisi, S., 1995: Gene conservation in pine species. A discussion is presented of the case for considering European pine species for genetic conservation programmes: Pinus sylvestris, P. leucodermis, P. nigra, P. cembra and P. halepensis. The usefulness of genetic markers (morphological, physiologic...

Rappaz, R., 1968: Melitaea aurinia Rott. altitude maximale. Mitteilungen aus der Entomologischen Gesellschaft Basel (N F): 18: 34

Klompenhouwer, E.G.; Duijm, L.E.M.; Voogd, A.C.; den Heeten, G.J.; Nederend, J.; Jansen, F.H.; Broeders, M.J.M., 2014: Variations in screening outcome among pairs of screening radiologists at non-blinded double reading of screening mammograms: a population-based study. Substantial inter-observer variability in screening mammography interpretation has been reported at single reading. However, screening results of pairs of screening radiologists have not yet been published. We determined variations in screening pe...

Odiyo P.O., 1975: Seasonal distribution and migrations of agrotis ipsilon lepidoptera noctuidae. Tropical Pest Bulletin (4): 1-26

Davis, F., A.; Liu, H.; Chen, B.-Chi; Zho, P., 1998: Oxidation of 1,3-dicarbonyl compounds using (camphorylsulfonyl)oxaziridines. The oxidation of 1,3-dicarbonyl compounds with (camphorylsulfonyl)oxaziridines 2 was studied in both cyclic and acyclic systems. Two reaction pathways were identified: enolate alpha-hydroxylation and a novel Baeyer-Villiger type oxidation. The Bae...

Tizian, C.; Brenner, P.; Berger, A., 1988: The one-stage surgical treatment of multilocated pressure sores using various myocutaneous island flaps. Report on 32 patients suffering from chronical pressure sores (n = 18 solitary, n = 14 multilocated), Campbell stages IV-VI, overlaying sacral bone, ischial tuberosity and tuber femoris, which were treated by using various combinations of myocutan...

Graham, M.Y.; Graham, T.L., 1994: Wound-Associated Competency Factors Are Required for the Proximal Cell Responses of Soybean to the Phytophthora sojae Wall Glucan Elicitor. Intact soybean (Glycine max L. [Merr.]) tissues show distinct proximal and distal cell responses to the Phytophthora sojae (Kauf. and Gerde.) wall glucan elicitor. Proximal cells respond with accumulations of glyceollin and phenolic polymers, wher...

Toribara, T.Y., 2001: Analysis of single hair by XRF discloses mercury intake. Utilizing information obtained from the X-ray fluorescence linear scanning along a single strand of hair in a recent fatal exposure to dimethylmercury, it was possible to determine the circumstances leading to the fatal result. When the Dartmouth...