geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Good clinical response to gefitinib in a non-small cell lung cancer patient harboring a rare somatic epidermal growth factor gene point mutation; codon 768 AGC > ATC in exon 20 (S768I)


, : Good clinical response to gefitinib in a non-small cell lung cancer patient harboring a rare somatic epidermal growth factor gene point mutation; codon 768 AGC > ATC in exon 20 (S768I). Japanese Journal of Clinical Oncology 40(11): 1105-1109

Recently, two small-molecule kinase inhibitors targeting epidermal growth factor receptor have proven effective in the treatment of non-small cell lung cancer. There are specific activating mutations within the tyrosine kinase domain of epidermal growth factor receptor related to the sensitivity of tyrosine kinase inhibitors. However, it is unknown whether rare mutations in the N-lobe (exons 18-20) and the C-lobe (exon 21) of the epidermal growth factor receptor kinase domain other than L858R in exon 21 and the in-frame deletion in exon 19 may predict the effectiveness of epidermal growth factor receptor-tyrosine kinase inhibitors. We reported a case of non-small cell lung cancer harboring a rare epidermal growth factor somatic mutation, codon 768 AGC > ATC in exon 20 (S768I), who showed a good clinical response to gefitinib. Therefore, we may suggest that this rare mutation (S768I in exon 20) may not be an insensitive epidermal growth factor receptor somatic mutation in vivo.

US$19.90

PMID: 20522446

DOI: 10.1093/jjco/hyq087


Other references

Lamprecht, H., 1960: On the leaf colours of phanerogams. After a survey of the effects of environment and genetic background on the expression of colour mutations, the classification of genetically determined colours into the following three groups is proposed: (1) the chlorovegetus group of vigourous c...

Unozawa, T.; Kimura, K.; Ohto, M.; Saisho, H.; Morita, M.; Ebara, M.; Kasuya, N.; Tsuchiya, Y.; Okuda, K., 1985: Clinical study on relationship between an anomalous pancreatico-biliary ductal union and carcinoma of the gallbladder. Nihon Shokakibyo Gakkai Zasshi 82(3): 473-482

Gorman, S.W.; Teasdale, R.D.; Cullis, C.A., 1992: Structure and organization of the 5S rRNA genes (5S DNA) in Pinus radiata (Pinaceae). A 5S rRNA gene (5S DNA) from the conifer Pinus radiata has been cloned and characterized at the nucleotide, genomic and chromosomal levels. Sequencing revealed a repeat unit of 524 base pairs which is present in approximately 3000 copies per diplo...

Henderson, S.L.; Dandie, C.E.; Patten, C.L.; Zebarth, B.J.; Burton, D.L.; Trevors, J.T.; Goyer, C., 2010: Changes in denitrifier abundance, denitrification gene mRNA levels, nitrous oxide emissions, and denitrification in anoxic soil microcosms amended with glucose and plant residues. In agricultural cropping systems, crop residues are sources of organic carbon (C), an important factor influencing denitrification. The effects of red clover, soybean, and barley plant residues and of glucose on denitrifier abundance, denitrificat...

Perdikis, D.C.; Lykouressis, D.P.; Economou, L.P., 1999: The influence of temperature, photoperiod and plant type on the predation rate of Macrolophus pygmaeus on Myzus persicae. The effect of temperature and photoperiod on the rate of predation of nymphs and adults of the predator Macrolophus pygmaeus was studied using Myzus persicae prey feeding on egg-plant and pepper plants. The experiments were conducted at three phot...

Anonymous, 2006: Replique aux cris de desespoirs d'un taxonomiste sinistre de Stavanger. Retort with the despairs crys of a disaster victim taxonomist of Stavanger. Author gives his retort to absurd criticism of Knut Rognes, which thinks that the genus Bengalia Robineau-Desvoidy is only the taxon of the Calliphoridae family, which inc...

Muldoon L.L.; Jamieson G.A.Jr; Villereal M.L., 1987: Calcium mobilization in permeabilized fibroblasts effects of inositol trisphosphate o vanadate mitogens phorbol ester and gtp. Utilizing a digitonin-permeabilized cell system, we have studied the release of calcium from a non-mitochondria intracelular compartment in cultured human fibroblasts (HSWP cells). Addition of 1 mM MgATP to a monolayer of permeabilized cells in a...

Mcgowan, G.K.; M.S.ndler, 1967: Symposium on the thryoid gland. The 18 papers presented in this symposium discuss the following diagnostic procedures, clinical applications, structure and functions of the thyroid: Biosynthesis and action of thyroid hormones; control of thyroid secretion; the radioimmunoassay o...

Fel'dblium, I.V.; Nikolaeva, A.M.; Kuz'ianin, A.V.; Borisova, V.N.; Mel'nikov, V.A.; Chuprinina, R.P.; Perelygina, O.V.; Shalunova, N.V.; Semenova, V.D.; Griaznova, D.V.; Pushkareva, E.V.; Uvitskiĭ, A.Iu.; Alekseeva, I.A.; Konopleva, O.A.; Budanov, M.V.; Iakovleva, I.M., 2004: Evaluation of the reactogenicity and immunogenic potency of combined vaccine "Bubo-Kok" in the immunization of children against diphtheria, tetanus, pertussis and viral hepatitis B. Combined vaccine "Bubo-Kok" is characterized by safety and high immunological activity. The number of postvaccinal reactions in children aged 1 and 2 years, immunized with vaccine "Bubo-Kok", was not statistically different fro...

Finlayson, JC., 1978: Irruptive behaviour in the Dartford warbler Sylvia undata dartfordiensis, Latham at Gibraltar. Alectoris, 11: 47