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Gradient generation platforms: new directions for an established microfluidic technology


, : Gradient generation platforms: new directions for an established microfluidic technology. Lab on A Chip 14(17): 3241-3247

Microscale platforms are enabling for cell-based studies as they allow the recapitulation of physiological conditions such as extracellular matrix (ECM) configurations and soluble factors interactions. Gradient generation platforms have been one of the few applications of microfluidics that have begun to be translated to biological laboratories and may become a new "gold standard". Though gradient generation platforms are now established, their full potential has not yet been realized. Here, we will provide our perspective on milestones achieved in the development of gradient generation and cell migration platforms, as well as emerging directions such as using cell migration as a diagnostic readout and attaining mechanistic information from cell migration models.

US$19.90

PMID: 25008971

DOI: 10.1039/c4lc00448e


Other references

Levitt, S.B.; Smith, R.B.; Ship, A.G., 1976: Iatrogenic microphallus secondary to circumcision. Three cases of apparent microphallus secondary to overzealous circumcision are presented. Proper diagnosis avoids unnecessary diagnostic studies. Moreover, a good functional and cosmetic result is virtually assured with appropriate resurfacing and...

Massoud, J.; Arfaa, F.; Mousavi, M., 1973: Field trials of molluscicide (WL 8008) in Dezful bilharziasis control project area, Khuzestan, Iran. Field trials with 2(FX/28), a 16.5% w/v emulsifiable concentrate of WL8008 (N-tritylmorpholine) in tetrachloroethylene were carried out in 2 canals and 2 ponds Khuzestan, Iran, where Schistosoma haematobium and S. bovis are transmitted by Bulinus...

Setz, U.; Frank, U.; Anding, K.; Garbe, A.; Daschner, F.D., 1994: Shunt nephritis associated with Propionibacterium acnes. Membranoproliferative glomerulonephritis was observed in a 22-year-old male patient in whom a ventriculoatrial shunt and a ventricular catheter were implanted after he was diagnosed in September 1989 with a cerebral cyst. Propionibacterium acnes i...

Laniado-Schwartzman, M.; Abraham, N.G.; Sacerdoti, D.; Escalante, B.; McGiff, J.C., 1992: Effect of acute and chronic treatment of tin on blood pressure in spontaneously hypertensive rats. Cytochrome P450-dependent metabolites of arachidonic acid (AA) are increased in the kidneys of spontaneously hypertensive rats (SHR) as compared to control rats (WKY) in the period of rapid elevation of blood pressure (BP) from 5 to 13 weeks. We t...

Poulsen, S.Højklint.; Urup, T.; Grunnet, K.; Christensen, I.Jarle.; Larsen, V.Andrée.; Jensen, M.Lundemann.; A.R.senschöld, P.Munck.; Poulsen, H.Skovgaard.; Law, I., 2016: The prognostic value of FET PET at radiotherapy planning in newly diagnosed glioblastoma. Glioblastoma patients show a great variability in progression free survival (PFS) and overall survival (OS). To gain additional pretherapeutic information, we explored the potential of O-(2-<sup>18</sup>F-fluoroethyl)-L-tyrosine (FET)...

Koopowitz, H.; Ewer, D.W., 1970: Observations on the myo-neural physiology of a polyclad flatworm: inhibitory systems. Journal of Experimental Biology 53(1): 1-8

Goto, Y.; Ujiie, Y.; Takanami, A.; Kuwano, A.; Uchlyama, T., 1959: Changes of blood ATP, inorganic phosphorus and blood sugar after injection of glueuronic acid in diabetics and nondiabetics. The effects of glueuronic acid on blood ATP (adenosine triphosphate), inorganic P and blood sugar were observed in 9 diabetic patients and 7 nondiabetic adults. The blood ATP (measured as 7 minutes' hydrolyzed P) was elevated distinctly after...

Crain, S.M.; Shen, K.F.i, 2000: Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists. This invention relates to a method for selectively enhancing the analgesic potency of a bimodally-acting opioid agonist such as morphine and simultaneously attenuating anti-analgesia, hyperalgesia, hyperexcitability, physical dependence and/or tol...

Ross, P.M.; Lyne, E.D., 1980: The Grice procedure: indications and evaluation of long-term results. The major indication for the Grice extra-articular subtalar arthrodesis is valgus deformity occurring after poliomyelitis. Unsatisfactory long-term results in valgus deformities secondary to other neuromuscular conditions, myelodysplasia and flexi...

Aldecoa, E.A.; Mayordomo, F.G., 1992: Modified internal bleaching of severe tetracycline discoloration: a 6-year clinical evaluation. Since 1985, 534 severely discolored teeth have been treated with intentional endodontics and internal bleaching; of these, 258 were treated with the conventional technique and 276 were treated with the modified technique. Six years of clinical and...