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HER1 R497K and HER2 I655V polymorphisms are linked to development of breast cancer

, : HER1 R497K and HER2 I655V polymorphisms are linked to development of breast cancer. Disease Markers 34(6): 407-417

Polymorphism of the genes of Human Epidermal growth factor receptor1 (HER1) and receptor2 (HER2) have been reported to be linked to pathogenesis of several malignant tumors but still there is contradiction regarding their association with breast cancer. In this case control study we aimed to analyze the frequency of HER1 R497K (rs 11543848) and HER2 I655V (rs 1136201) Polymorphisms in breast cancer. The frequency of HER1 Arg(R) 497Lys (K) and HER2 Ile (I) 655Val (V) polymorphisms were tested in 64 breast cancer patients and 86 normal control by polymerase chain reaction followed by restriction fragment polymorphism detection. Immunohistochemical analysis was done for HER2 protein on the available 18 malignant tissue samples. HER1 497K and HER2 655V variant had significantly increased breast cancer risk (OR=2.6, 95% CI 1.6-4.2, OR=2.2, 95% CI 1.2-4.1, p< 0.05) respectively. Moreover, combined HER1 K497 and HER2 V655 variant was detected in 26.6% malignant in comparison to 8.14% of control group (OR=4.1, 95% CI 1.58-10.57), but, no significant association was noticed between both Polymorphisms and clinicopathological features of the disease. As regard HER2 immunohistochemical expression no significant correlation was revealed with HER2 655V polymorphism. our findings suggest that HER1 497K and HER2 655V polymorphisms are potential risk factor for development of breast cancer.


PMID: 23594562

DOI: 10.3233/DMA-130989

Other references

Noble, R.L., 1965: Life history and ecology of western blacknose dace, Boone County, Iowa, 1963-1964. Proceedings of the Iowa Academy of Science, 72: 282-293

Isakow, W.; Schuster, D.P., 2006: Extravascular lung water measurements and hemodynamic monitoring in the critically ill: bedside alternatives to the pulmonary artery catheter. Extravascular lung water measurements and hemodynamic monitoring in the critically ill: bedside alternatives to the pulmonary artery catheter. Am J Physiol Lung Cell Mol Physiol 291: L1118-L1131, 2006. First published August 4, 2006; doi:10.1152/a...

Jaynes, W.F.; Zartman, R.E.; Sosebee, R.E.; Wester, D.B., 2003: Biosolids decomposition after surface applications in west Texas. In a semiarid environment, climate is a critical factor in the decomposition of surface-applied biosolids. This study examined the effect of 2- to 7-yr exposure times on the composition of single applications of New York, NY biosolids in western T...

Rosales, F.; Ritari, S.J.; Sakami, W., 1970: Formation of the N5-methyltetrahydrofolate-homocysteine methyltransferase holoenzyme from apoenzyme and adenosyl-B 12. Biochemical and Biophysical Research Communications 40(2): 271-276

Gadian D.G.; Payne J.A.; Bryant D.J.; Young I.R.; Carr D.H.; Bydder G.M., 1985: Gadolinium diethylenetriaminepentaacetic acid as a contrast agent in magnetic resonance imaging theoretical projections and practical observations. The theoretical basis for the use of paramagnetic agents to enhance proton relaxation is described. Factors of importance in the design of contrast agents are considered. Measurements of changes in T1 [spin lattic relaxation time] and T2 [spin-spi...

Kovalev V.P.; Nosova T.G., 1983: Problems of epigene changes and radiogeochemical transformation during Hercynian magmatism in sedimentary cover of Minousinsk Mountains. Trudy Instituta Geologii i Geofiziki (Novosibirsk) 525: 125-181

Langer, B., 1989: Surgical research: its importance in the evolution of the specialty of general surgery. General surgery is a specialty that has gradually been defined by the evolution of surgery in general, the major events being the identification and separation of subspecialties. Advances in knowledge brought about by research have been the major...

Gold, M.; Dunton, C., J.; Murray, J.; Macones, G.; Hanau, C.; Carlson, J., A.,. Jr.;, 1996: Loop electrocautery excisional procedure: Therapeutic effectiveness as ablation and a conization equivalent. This study was designed to compare the effectiveness of loop excision procedures as ablation and conization equivalents, and their use in recurrent cervical high-grade dysplasia patients. We retrospectively reviewed patients undergoing loop proced...

Selden, C.; Wang, Y.; Morgan, N.; Hodgson, H.J.F., 1994: Structural and functional characterization of developing ectopic liver during successful treatment of murine histidinemia by intraperitoneal transplantation of mixed hepatocyte and non-parenchymal cell populations. Hepatology 20(4 PART 2): 198A

Chiarugi, A.; Moskowitz, M.A., 2002: PARP-1- a perpetrator of apoptotic cell death?. A study in this issue reports that the release of a powerful mitochondrial cytotoxin that promotes apoptotic cell death is triggered by activation of poly(ADP-ribose) polymerase-1 (PARP-1). Yu et al. show that PARP-1 activity prompted the release...