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Heritability of premature mitral valve disease in Cavalier King Charles spaniels

, : Heritability of premature mitral valve disease in Cavalier King Charles spaniels. Veterinary Journal 188(1): 73-76

Mixed model analysis of 1252 records of cardiac auscultation of 4- to 5-year-old Cavalier King Charles spaniels (CKCS) from 1991 to 2008 in conjunction with the Kennel Club pedigree records of all dogs registered from the mid 1980s to September 2007 was used to estimate variance parameters of premature mitral valve disease (MVD). Data were limited to dogs ≥4 and <5 years of age to ensure diagnostic distinction between early and late onset MVD. Cardiac murmurs were detected in 108/1252 (8.6%) dogs. Heritability estimates of 0.67 (standard error, SE 0.071) for the grade of murmur and 0.33 (SE 0.072) for the presence/absence of murmur were calculated. The variance due to clinician was 0.02 (SE 0.012) for grade and 0.03 (SE 0.017) for presence/absence of murmur. These results indicate that the presence and severity of MVD, as assessed by cardiac auscultation, in 4- to 5-year-old CKCS is highly heritable and that selection against the disease should be successful.


PMID: 20347358

DOI: 10.1016/j.tvjl.2010.02.016

Other references

Marples, M.J.; D.M.Nna, M.E., 1952: The incidence of Candida albicans in Dunedin, New Zealand. Mouth, skin or feces were examined for the presence of C. albicans in a group of 278 children, and mouth and skin were examined in a group of 137 young adults. Among the children, C. albicans was found in 33.5%, of mouth washings and in 30.8% of f...

Mishra, M.; Dubey, N.; Totey, S.M.; Bhat, K.V.; Babu, S.; Awasthi Kalia, M.; Anand, R.K., 2002: Phylogenetic relationships and genetic polymorphisms in wild Indian mice. Randomly amplified polymorphic DNA (RAPD) analysis was used to examine the extent of variability in 11 Indian wild derived commensal house mice (Mus musculus) populations and compared with inbred strains of musculus and domesticus subspecies as we...

Takayama, S.; Koyama, T.; Taketomi, H., 1959: Studies on Trawl net - III Observation of the configuration of a trawl net using a large sized model. With a view to introducing a trawl net with optimal configuration under towing, model experiments were performed in a laboratory tank. The size and shape of the buoys, the kite and other accessories were determined according to Tauti's law of...

Lan Labao; Hudleston Peter, 1996: The effect of anisotropy on the development of structures in fold-and-thrust belts. International Geological Congress, Abstracts--Congres Geologique Internationale, Resumes 30, Vol

Bons, J., 1989: Psammodromus algirus. Unknown

Hedervari Peter, 1967: Investigations regarding the earth's seismicity-pt. 5, on the earthquake geography of the pacific ocean and the seismotectonical importance of the andesite line. section 2, the andesite line in detail and its physical nature. Gerlands Beitraege zur Geophysik 76(6): 467-490

Buga, S.F.; Radyna, A.A.; Boyarchuk, V.E., 1996: Monitoring of Fusarium nivale (Fr.) Ges. population sensitivity to fundazol. Monitoring of the sensitive populations of the fungus Fusarium nivale to fundazol showed a high resistance of Logoisk, Priluks and Minsk populations.

Zhao, J.; Li, X.; Yang, Y.; Zhu, D.; Zhang, C.; Liu, D.; Wu, K.; Zhao, S., 2016: Effect of YAP1 silencing on esophageal cancer. YAP1, the nuclear effector of the Hippo pathway, has become an attractive target for treatment of malignancies and is a candidate oncogene in esophageal cancer (EC). We hypothesized that knockdown of YAP1 could suppress EC and could be used for ta...

Wcisło, W., 2014: A modified acetylene method of determination of the cardiac output of man. Bulletin International de L'academie Polonaise des Sciences et des Lettres. Classe de Medecine 1(10): 151-168

Lee, K.; Lee, J-Hyung.; Ryu, S.Yong.; Cho, M.Hwan.; Lee, J., 2015: Stilbenes reduce Staphylococcus aureus hemolysis, biofilm formation, and virulence. Stilbenoids have a broad range of beneficial health effects. On the other hand, the emergence of antibiotic-resistant Staphylococcus aureus presents a worldwide problem that requires new antibiotics or nonantibiotic strategies. S. aureus produces...