geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Hierarchical kernel mixture models for the prediction of AIDS disease progression using HIV structural gp120 profiles


, : Hierarchical kernel mixture models for the prediction of AIDS disease progression using HIV structural gp120 profiles. Bmc Genomics 11 Suppl 4: S22-S22

Changes to the glycosylation profile on HIV gp120 can influence viral pathogenesis and alter AIDS disease progression. The characterization of glycosylation differences at the sequence level is inadequate as the placement of carbohydrates is structurally complex. However, no structural framework is available to date for the study of HIV disease progression. In this study, we propose a novel machine-learning based framework for the prediction of AIDS disease progression in three stages (RP, SP, and LTNP) using the HIV structural gp120 profile. This new intelligent framework proves to be accurate and provides an important benchmark for predicting AIDS disease progression computationally. The model is trained using a novel HIV gp120 glycosylation structural profile to detect possible stages of AIDS disease progression for the target sequences of HIV+ individuals. The performance of the proposed model was compared to seven existing different machine-learning models on newly proposed gp120-Benchmark_1 dataset in terms of error-rate (MSE), accuracy (CCI), stability (STD), and complexity (TBM). The novel framework showed better predictive performance with 67.82% CCI, 30.21 MSE, 0.8 STD, and 2.62 TBM on the three stages of AIDS disease progression of 50 HIV+ individuals. This framework is an invaluable bioinformatics tool that will be useful to the clinical assessment of viral pathogenesis.

US$19.90

PMID: 21143806

DOI: 10.1186/1471-2164-11-S4-S22


Other references

Vora M.M.; Y.C.S.; Blanton D.D.Jr, 1981: Synthesis of pyrrolo 2 3 b azepine 4 7 dione derivatives. The Dieckmann reaction was successfully applied for the 1st time in the synthesis of pyrrolo[2,3-.beta.]azepines [potential antibiotics].

Scheeres D.J.; Gaskell R.W.; Abe M.; Nakamura R.; Yoshikawa M., 2007: Itokawa, YORP and seismic shaking. Abstracts of Papers Submitted to the Lunar and Planetary Science Conference: ages ; Abstract 1599. 2007.

Heimes, B.; Schick, T.; Brinkmann, C.K.; Wiedon, A.; Haegele, B.; Kirchhof, B.; Holz, F.G.; Pauleikhoff, D.; Ziemssen, F.; Liakopoulos, S.; Spital, G.; Schmitz-Valckenberg, S., 2016: Design of the ORCA module in the OCEAN study : Evaluation of SD-OCT results in daily routine practice. The prevalence of blindness as defined by law could be reduced by the introduction of anti-vascular endothelial growth factor (VEGF) therapy. Because the treatment is governed by patient needs, mostly using morphological criteria, imaging diagnost...

Rasheed, S.; Bashir, K.; Matsui, A.; Tanaka, M.; Seki, M., 2016: Transcriptomic Analysis of Soil-Grown Arabidopsis thaliana Roots and Shoots in Response to a Drought Stress. Drought stress has a negative impact on crop yield. Thus, understanding the molecular mechanisms responsible for plant drought stress tolerance is essential for improving this beneficial trait in crops. In the current study, a transcriptional anal...

Fortenberry, R.C.; King, R.A.; Stanton, J.F.; Crawford, T.Daniel., 2010: A benchmark study of the vertical electronic spectra of the linear chain radicals C(2)H and C(4)H. The ability of coupled-cluster models to predict vertical excitation energies is tested on the electronic states of carbon-chain radicals of particular relevance to interstellar chemistry. Using spin-unrestricted and -restricted reference wave fun...

Oatis, J.E.Jr; Knapp, D.R., 1998: Synthesis and photochemistry of two cleavable heterobifunctional benzophenone protein crosslinkers. Two new heterobifunctional protein crosslinkers were synthesized. These reagents contain the cysteine reactive maleimido group connected via a cleavable ester linkage to the benzophenone photoactivatable group.

Avriel, A.; Rozenberg, D.; Raviv, Y.; Heimer, D.; Bar-Shai, A.; Gavish, R.; Sheynin, J.; Douvdevani, A., 2017: Prognostic utility of admission cell-free DNA levels in patients with chronic obstructive pulmonary disease exacerbations. Chronic obstructive pulmonary disease exacerbations (COPDEs) are associated with increased morbidity and mortality. Cell-free DNA (cfDNA) is a novel biomarker associated with clinical outcomes in several disease states but has not been studied in...

Beran, F., 1975: Modern plant protection means health protection. Forderungsdienst 23 (5) 161

Makaveev T.; Stefanova S., 1992: New phosphohexose isomerase phi allele in the east balkan local swine population in bulgaria. Van de Veghe et al. (1988) found lately four genotypes of the polymorphic PHI locus in erythrocytes of swine from the local East Balkan population in Bulgaria. After investigating the genetic polymorphism of the enzyme in erythrocytes of 175 swine...

Reininga, I.H.F.; el Moumni, M.; Bulstra, S.K.; Olthof, M.G.L.; Wendt, K.W.; Stevens, M., 2012: Cross-cultural adaptation of the Dutch Short Musculoskeletal Function Assessment questionnaire (SMFA-NL): internal consistency, validity, repeatability and responsiveness. The purpose of this study was to translate and culturally adapt the Dutch version of the Short Musculoskeletal Function Assessment questionnaire (SMFA-NL) and to investigate the internal consistency, validity, repeatability and responsiveness of t...