geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

High expression of GTPase regulator associated with the focal adhesion kinase (GRAF) is a favorable prognostic factor in acute myeloid leukemia


, : High expression of GTPase regulator associated with the focal adhesion kinase (GRAF) is a favorable prognostic factor in acute myeloid leukemia. Blood Cells, Molecules & Diseases 53(4): 185-188

GRAF is a recognized tumor suppressor gene that was found inactivated in AML. However, the prognostic role of a GRAF transcript has not been studied in patients with AML. In this study, we investigated the expression of the GRAF transcript by real time quantitative PCR in 60 AML patients and 30 healthy age and sex matched controls. GRAF expression was significantly lower in patients with AML when compared to controls (P=0.008). There were no significant differences in clinical features, FAB subtypes and cytogenetic risk subgroups between patients with high and low GRAF expression levels. Kaplan-Meier analysis showed that patients with high GRAF expression had longer overall survival (OS). Multivariate analysis revealed that, besides WBC count, GRAF expression was also an independent prognostic factor for AML. We provide evidence that high GRAF expression is a favorable prognostic marker in patients with AML.

US$19.90

PMID: 25088035

DOI: 10.1016/j.bcmd.2014.07.004


Other references

Sax, Karl, 1926: Varieties of ensilage corn for Maine. Maine Agric Exp Sta Bull 330: 49-56

Wikiera, B.; Bieniasz, J.; Barg, E.; Głab, E.; Noczyńska, A., 2010: Lipoprotein a (Lp(a)) in patients with Turner's syndrome. Women with Turner syndrome (TS) more frequently develop cardiovascular disease. Abnormal lipid metabolism is a well known risk factor for ischemic heart disease. was to evaluate serum lipid abnormalities, particularly lipoprotein (a) (Lp(a)) in pa...

Roiser, J.P.; Levy, J.; Fromm, S.J.; Nugent, A.C.; Talagala, S.Lalith.; Hasler, G.; Henn, F.A.; Sahakian, B.J.; Drevets, W.C., 2009: The effects of tryptophan depletion on neural responses to emotional words in remitted depression. Biological Psychiatry 66(5): 441-450

Zastre; Roshko; Williams, 1985: Critical effects in the reversible, nonlinear susceptibility of PdMn spin glasses. Physical Review. B, Condensed Matter 32(11): 7597-7599

L.P.bic C.; Farineau N.; Roussaux J., 1983: Effects of 6 benzylamino purine and potassium chloride on the greening of detached cucumber cucumis sativus cotyledons. Etiolated cotyledons of cucumber (C. sativus L.) were excised and maintained on water or transfered at various times to 6-benzylaminopurine (BA, 10-6 g/ml) or KCl (10-2 M) or a combination of BA+KCl at the same concentrations. The experiment was c...

Boekhout-Mussert, M.J.; Briet, E.; van Brummelen, P.; Lemkes, H.H.; Loeliger, E.A., 1978: Arterial thromboembolic complications with aortic ball valve prostheses. American Heart Journal 95(2): 270-272

Almquist, H.J.; Merritt, J.B., 1953: Effect of crystalline trypsin on the raw soybean growth inhibitor. Crystalline trypsin, added to chick diets which contained 5% of protein furnished as raw soybean meal and 15% as cooked soybean meal, improved the rate of gain of the chicks. The effect is attributed to inactivation, at least in part, of the anti-...

Crain, S.M.; Crain, B.; Makman, M.H., 1987: Pertussis toxin blocks depressant effects of opioid, monoaminergic and muscarinic agonists on dorsal-horn network responses in spinal cord-ganglion cultures. After chronic exposure of mouse spinal cord-ganglion explants to morphine, the acute depressant effects of opioids on sensory-evoked dorsal-horn network responses are markedly attenuated, and characteristic cord discharges can then occur even in t...

Brown, JNB.; Verhage, M.; Morris, RP., 1991: Crab plovers on Jazirat Abu al Abyad. Tribulus. October; 12: 13-15

Puska, P., 2009: Commentary on active living: from research to practice?. American Journal of Preventive Medicine 36(2 Suppl): S57-S59