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High levels of IgG3 anti ICB2-5 in Plasmodium vivax-infected individuals who did not develop symptoms


, : High levels of IgG3 anti ICB2-5 in Plasmodium vivax-infected individuals who did not develop symptoms. Malaria Journal 12(): 294-294

Plasmodium vivax has the potential to infect 2.85 billion individuals worldwide. Nevertheless, the limited number of studies investigating the immune status of individuals living in malaria-endemic areas, as well as the lack of reports investigating serological markers associated with clinical protection, has hampered development of vaccines for P. vivax. It was previously demonstrated that naturally total IgG against the N-terminus of P. vivax merozoite surface protein 1 (Pv-MSP1) was associated with reduced risk of malarial infection. Immune response against Pv-MSP1 (N-terminus) of 313 residents of the Rio Pardo rural settlement (Amazonas State, Brazil) was evaluated in a cross-sectional and longitudinal follow up over two months (on site) wherein gold standard diagnosis by thick blood smear and rRNA gene-based nested real-time PCR were used to discriminate symptomless Plasmodium vivax-infected individuals who did not develop clinical symptoms during a 2-months from those uninfected ones or who have had acute malaria. The acquisition of antibodies against Pv-MSP1 was also evaluated as survival analysis by prospective study over a year collecting information of new malaria infections in surveillance database. The majority of P. vivax-infected individuals (52-67%) showed immune recognition of the N-terminus of Pv-MSP1. Interesting data on infected individuals who have not developed symptoms, total IgG levels against the N-terminus Pv-MSP1 were age-dependent and the IgG3 levels were significantly higher than levels of subjects had acute malaria or those uninfected ones. The total IgG anti ICB2-5 was detected to be an important factor of protection against new malaria vivax attacks in survival analysis in a prospective survey (p = 0.029). The study findings illustrate the importance of IgG3 associated to 2-months of symptomless in P. vivax infected individuals and open perspectives for the rationale of malaria vaccine designs capable to sustain high levels of IgG3 against polymorphic malaria antigens.

PMID: 23977965

DOI: 10.1186/1475-2875-12-294


Other references

Jakobsen C J.B.; Hansen V.; Jensen J.J.; Grabe N., 1989: Contamination of subclavian vein catheters an intraluminal culture method. An intraluminal culture method was evaluated for central venous catheters and compared to conventional catheter tip cultures and cultures from the insertion site. The colonization-rate of the catheters was 43.7% using conventional tip culture, 34....

Sawai, H.; Okada, Y.; Funahashi, H.; Matsuo, Y.; Takahashi, H.; Takeyama, H.; Manabe, T., 2005: Activation of focal adhesion kinase enhances the adhesion and invasion of pancreatic cancer cells via extracellular signal-regulated kinase-1/2 signaling pathway activation. Background: Interaction with integrin and focal adhesion kinase (FAK) regulates the cancer cell adhesion and invasion into extracellular matrix (ECM). In addition, phosphorylation of FAK correlates with the increase of cell motility and invasion....

Anonymous, 2012: Marginal Mass in Latin America changes in how poverty is conceptualised and addressed 4 years after the theory. As abordagens e express es da quest o social como pobreza envolvem discuss es acerca da configura o e do enfrentamento de fraturas sociais, vinculadas ao processo de reestrutura o produtiva capitalista, em diversas dimens es: econ micas, pol ticas...

Malinin, LK.; Bazarov, MI., 1981: Vertical distribution of fish below the dams. Biologiya Vnutrennikh Vod Informatsionnyi Byulleten': 32-34 No. 50

Kuehnel, W., 1964: Histological Studies On The Embryonic Sheath In White Mice. Zeitschrift für Zellforschung und Mikroskopische Anatomie 63: 194-207

Burki, F.; Berney, Cédric.; Pawlowski, J., 2002: Phylogenetic position of Gromia oviformis Dujardin inferred from nuclear-encoded small subunit ribosomal DNA. Gromia oviformis Dujardin is a common marine protist characterised by a large, globular test and filose pseudopodia. First considered a foraminifer, Gromia was later placed within the Filosea and recently included among amoebae of uncertain affini...

Trinh, L.; Miyake, K.K.; Dirbas, F.M.; Kothary, N.; Horst, K.C.; Lipson, J.A.; Carpenter, C.; Thompson, A.C.; Ikeda, D.M., 2016: CT-Guided Wire Localization for Involved Axillary Lymph Nodes After Neo-adjuvant Chemotherapy in Patients With Initially Node-Positive Breast Cancer. Resection of biopsy-proven involved axillary lymph nodes (iALNs) is important to reduce the false-negative rates of sentinel lymph node (SLN) biopsy after neo-adjuvant chemotherapy (NAC) in patients with initially node-positive breast cancer. Preo...

Lungarotti, F.; Gazzaniga, M.; Vassallo, C.; Ramusino, L.C., 1959: The sympathetic ganglionic system in artificial hibernation. Histological and histochemical study. Minerva Chirurgica 14: 1559-1563

Powell, R.L.; Reyes, S.R.; Lannutti, D.I., 2006: Molecular barcoding, DNA from snake venom, and toxinological research: Considerations and concerns. The problem of species identification in toxinological research and solutions such as molecular barcoding and DNA extraction from venom samples are addressed. Molecular barcoding is controversial with both perceived advantages and inherent proble...

Grüner, O.; Bilzer, N.; Frevel, H.J., 1989: Alcohol intoxicated female drivers in Schleswig-Holstein between 1977 and 1987. This paper reports data on frequency of blood alcohol analyses of female drivers between the years 1977-1987 in Schleswig-Holstein, Germany, West. A comparison between the male and female drivers during the same period is made. Since the year 1980...