+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

High-dose density chemotherapy followed by simple trachelectomy: full-term pregnancy

, : High-dose density chemotherapy followed by simple trachelectomy: full-term pregnancy. International Journal of Gynecological Cancer 18(6): 1367-1371

We report five patients with early-stage cervical cancer who do not fulfill criteria of fertility-sparing surgery (tumor more than 2 cm in the biggest diameter or infiltrating more than half of stroma). Five patients received three cycles of dose density neoadjuvant chemotherapy (NAC) at a 10-day interval: cisplatin plus ifosfamide in squamous cell cancer or plus doxorubicin in adenocarcinoma with good tolerance. After NAC, they underwent laparoscopic pelvic lymphadenectomy and vaginal simple trachelectomy. Two patients had no residual tumor, two had only microscopic residual disease, and one had macroscopic residual disease. Two women became pregnant 5 and 8 months after surgery, one delivered in term healthy baby and one is now in the second trimester of pregnancy without any complications. NAC followed by fertility-sparing surgery seems to be feasible treatment for women with tumor bigger than 2 cm or infiltrated more than half of the stroma.


PMID: 18217969

DOI: 10.1111/j.1525-1438.2007.01178.x

Other references

Kökçam, I.; Ozercan, I.H., 2005: A case of linear lichen planus. Linear lichen planus (LLP) is a very rare form of lichen planus (LP) characterized by a linear distribution of the lichenoid lesions. It usually follows the lines of Blaschko with unilateral involvement. We report such a case of LLP. A 50-year-old...

Dedet, J.P.; Derouin, F.; Cornet, M., 1978: Natural infection of Phlebotomus duboscqi with the promastigotes of Leishmania in Senegal. Individuals of Phlebotomus duboscqi and Sergentomyia spp. from rodent burrows in Senegal were dissected and in 2 out of 45 female P. duboscqi promastigotes of Leishmania, which could be cultured on NNN medium, were found.

Benoit, P. et al., 1992: The agronomist's responsibilities. Agronomists in Quebec, Canada must work according to a code of ethics, setting out their responsibilities and obligations, and must act with foresight, care and knowledge. A relationship of confidence needs to be established with the client, and c...

Kotin, P., 1964: Environmental Carcinogenesis. Transactions & Studies of the College of Physicians of Philadelphia 32: 64-68

Zhang, M.; Dong, Z.; Li, J.; Zhao, G.; Chen, C.; Li, A., 2004: Humoral immunoreaction induced by TCR DNA vaccine for beta chain of T cell lymphoma. We exploited the humoral immunoreaction of mice induced by TCR DNA vaccine of beta chain of T cell lymphoma. The plasmids of pcDNA3.1/TCR V beta 8 was constructed. The BALB/c mice were randomly divided into four groups which were pcDNA3.1, pcDNA3....

Szabo, C.A.; Vollmer, D.G.; Cavazos, J.; Mayes, B.N., 2002: Electrocortical mapping of the occipital lobe with subdural electrodes Results in four patients. Epilepsia 43(Supplement 7): 114

Nugroho, A.; Lee, K.Ro.; Alam, M.Badrul.; Choi, J.Sue.; Park, H-Juhn., 2010: Isolation and quantitative analysis of peroxynitrite scavengers from Artemisia princeps var. orientalis. Young and mature Artemisia princeps var. orientalis (APO, Compositae) are used as a health food and a medicinal plant, respectively, in Korea. Here, we identified the in vitro potent peroxynitrite (ONOO(-))-scavenging effect (IC(50), 0.26 microg/m...

SCHERER.W.F.; MOYER.J.T.; IZUMI.T.; GRESSER.I.; McCOWN.J., 1959: Ecologic studies of Japanese encephalitis virus in Japan. VI. Swine infection. In a district near Tokyo most pigs became infected with the virus during August, as judged by antibody titres in blood plasma.

Cangialosi, C.P., 1985: Podiatric manifestations in patients with acute and chronic neurologic disorders. It is impossible to delineate, in the short space provided, the entire spectra of possible and potential podiatric manifestations of acute and chronic neurologic disease. An attempt has been made to delineate the neuroanatomic, neurophysiologic, e...

Andrade, Rúl.J.; Lucena, M.Isabel., 2012: Drugs prescription in patients with chronic liver disease: rules for adjusting doses and beyond. Revista Espanola de Enfermedades Digestivas 104(4): 161-164