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Hirsutalins A-H, eunicellin-based diterpenoids from the soft coral Cladiella hirsuta


, : Hirsutalins A-H, eunicellin-based diterpenoids from the soft coral Cladiella hirsuta. Journal of Natural Products 73(11): 1785-1791

Eight new eunicellin-base diterpenoids, hirsutalins A-H (1-8), were isolated from the soft coral Cladiella hirsuta. Their structures were elucidated by spectroscopic methods, particularly in 1D and 2D NMR experiments. The absolute configuration of 1 was determined by Mosher's method. Compounds 1, 5, and 6 have been shown to exhibit cytotoxicity toward several cancer cell lines. Compounds 2-4 and 8 were found to display significant in vitro anti-inflammatory activity in LPS-stimulated RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein, with compound 2 also effectively reducing the level of COX-2 protein.

US$19.90

PMID: 20979397

DOI: 10.1021/np100401f


Other references

Cai, S., 2015: Bending a beam by a generalized ideal elastomeric gel. NlmCategory="UNASSIGNED">A hybrid beam with a gel layer bonded on the top of an elastic non-swellable substrate has been commonly adopted to make various sensors and actuators. Usually, different models need to be developed for the hy...

Wilberding C.A.; Marks B.H., 1979: Pseudoirreversibility of di hydro ergocryptine adrenergic antagonism in the guinea pig vas deferens. Federation Proceedings 38(3 PART 1): 600

Saleuddin A.S.M., 1976: Ultrastructural studies on the structure and formation of the periostracum in Helisoma (Mollusca). Pages 309-337 1976

Overmier, Jb, 1979: Theories of instrumental learning. NATO ASI Advanced Science Institutes Series Series A Life Sciences 349-384

Swan, P.G.; Mahar, T.J., 2000: An objective technique for measurement of fibre crimp curvature 1: metrology. A measurement of fibre crimp curvature, based on light microscopy and image analysis, is outlined. This technique has been developed to enable routine measurement of the curvature of short sections of wool fibres from various wool fibre assemblies...

Smith, L.I.; Sprung, J.A., 1942: The chemistry of vitamin E. 31. 3, 5-Dinitrobenzazide as a reagent for preparation of derivatives of tocopherols. 31. With alpha -tocopherol in boiling toluene, 3: 5 dinitrobenzazide gave tho 3: 5-dinitrophenylurethane of alpha -tocopherol in 70 to 90 per cent. yield after one hour. The 3: 5-dinitrophenylurethanes of 6 tocopherols and of one simple 6-hydroxyc...

Zakopaĭlo, G.G.; Slotiuk, V.T.; Pshevorskiĭ, V.Ia., 1985: Effectiveness of tissue electrophoresis and ultrasonics in the complex treatment of patients over 50 years of age with newly detected pulmonary tuberculosis. Problemy Tuberkuleza: 71-72

Block, S.; Hedrick, J.; Tyler, R.; Smith, A.; Patterson, C.; Calandra, G.; Lewis, J.; Miller, W.; Nalin, D., 1993: Formalin-inactivated hepatitis A vaccine in children. Pediatric Research 33(4 PART 2): 115A

Brzozowski, J.; Jakubowski, R.; Pietrzykowa, A., 1953: Hygiene of work and health of workers during application of calcium arsenate in orchards. Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina 8: 263-280

Bishop, G.W., 1968: Potato leaf roll virus transmission as affected by plantlocality. In field experiments the pattern of potato leaf roll virus spread was closely correlated with distribution of Myzus persicae, which was highest on field margins. Plants adjacent to infected plants were highly susceptible to infection and control b...