+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Human IgG Fc-glycosylation profiling reveals associations with age, sex, female sex hormones and thyroid cancer

, : Human IgG Fc-glycosylation profiling reveals associations with age, sex, female sex hormones and thyroid cancer. Journal of Proteomics 75(10): 2824-2834

IgG functions rely on interactions of the Fc region with other proteins, which are optimized by tailoring of a conserved N-linked glycosylation at Asn-297. We conducted a study involving 735 control individuals and 138 thyroid cancer patients. Here we demonstrated that previously described age-related change in Fc-glycosylation was further characterized by definite sex specificity. In females, the incidences of most of glycosylated forms began to pose characteristic changes at ages of puberty or menopause. In addition, glycan-glycan relationships existed extensively within Fc glycosylation, which were characterized to be altered upon different states of subjects, such as age, sex and thyroid cancer. In thyroid cancer patients, detailed comparison of glycosylation incidences with control individuals yielded insight into aberrant change in IgG(1) Fc-glycosylation. This aberrant pattern was also featured by remarkable specificities of both age and sex. The receiver operating characteristic curve analysis was used to determine diagnostic values of Fc glycosylation. Finally, clinical measurement of two major female sex hormones estradiol and progesterone was conducted to determine potential associations of hormones with IgG Fc glycosylation. This study provided an important view to the associations of IgG Fc N-linked glycosylation with age, sex, female sex hormones and thyroid cancer. This article is part of a Special Issue entitled: Proteomics: The clinical link.


PMID: 22365975

DOI: 10.1016/j.jprot.2012.02.001

Other references

Qiao, F.; Sun, H., 2010: Simultaneous extraction of enrofloxacin and ciprofloxacin from chicken tissue by molecularly imprinted matrix solid-phase dispersion. An ofloxacin molecularly imprinted polymer was synthesized and used as a dispersant of matrix solid-phase dispersion for the determination of enrofloxacin and ciprofloxacin in chicken tissue. The selected dispersant shows high affinity to enroflox...

Manabe, M.; Minamisawa, M.; Matsuura, S., 1971: Gas-liquid chromatographic assay of sterigmatocystin. Gas-liquid chromatography of crude sterigmatocystin (from mouldy rice contaminated with Aspergillus versicolor) using 1.5% SE-30 (methyl silicone) on chromosorb W (diatom earth) showed better separation than did chromatography using other column m...

Matos, A.T. de; Sediyama, M.A.N.; Paiva Freitas, S. de; Vidigal, S.M.; Garcia, N.C.P., 1997: Effects of pig slurry application on soil chemical and microbiological characteristics. The effects of surface application of pig slurry at rates of 0, 50, 100, 150 and 200 msuperscript 3/ha on the total N, exchangeable K, Na, Cu and Zn contents of a Brazilian Ultisol were determined at various soil depths 2 months after application....

Moosleitner, Horst., 1992: The biology of the burrowing sea anemone, Actinodendron arboreum. Tropical Fish Hobbyist. April; 408: 34, 37-40, 44

Lyon, M.W., 1907: Notes on the Porcupines of the Malay Peninsula and Archipelago. Proceedings of the United States National Museum Smithsonian Institution Washington, 32 575-594

Lovasz A., 1989: Changes in the structure of products from the Gyongyosoroszi Mine. Banyaszati es Kohaszati Lapok, Banyaszat = Vengerskiy Zhurnal Gornogo Dela i Metallurgii, Gornoye Delo = Hungarian Journal of Mining and Metallurgy 122(9): 596-599

Macfarlan, R.I.; Burns, W.H.; White, D.O., 1977: 2 cyto toxic cells in peritoneal cavity of virus infected mice antibody dependent macrophages and nonspecific killer cells. Two new types of cell-mediated immune cytolysis of togavirus[Kunjin virus or Semliki Forest virus]-infected cells are compared. The peritoneal cavity of mice 2 days after infection contains a nonadherent, non-phagocytic, non-.theta.-bearing, tryps...

Patronov, D.N.kolov, V., 1978: Rotation of oak felling in high. Gorsko stopanstvo 34(9): 46-52

Fahrenkamp-Uppenbrink, J., 2017: Academic merit through a social filter. Science 355(6329): 1035-1037

Hammer, J.; Willson, T.; Horowitz, M.; Talley, N.J., 1999: Prevalence and determinants of chronic gastrointestinal symptoms in diabetes mellitus. Gastroenterology 116(4 PART 2): A63, April