+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Hydrangenone, a new isoprenoid with an unprecedented skeleton from Salvia hydrangea

, : Hydrangenone, a new isoprenoid with an unprecedented skeleton from Salvia hydrangea. Organic Letters 14(1): 166-169

Hydrangenone, a new heptacyclic isoprenoid with a 6/7/6/5/5 membered carbon ring skeleton, was isolated from the aerial parts of Salvia hydrangea. The structure was established by extensive NMR spectroscopic methods. The relative and absolute configuration of 1 was assigned by NOESY and X-ray crystallographic analysis and by comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Compound 1 showed in vitro antiplasmodial activity, with an IC(50) value of 1.4 μM against P. falciparum. A plausible biosynthetic pathway of 1 was also proposed.


PMID: 22133100

DOI: 10.1021/ol202953b

Other references

Maas, S.F.; Arkin, G.F., 1980: Sensitivity analysis of SORGF, a grain sorghum model. A sensitivity analysis was performed on a grain sorghum growth simulation model, to determine its response to changes in temperature, insolation, extractable soil water, population, row spacing, number of leaves, and plant leaf area, in terms of g...

Cueva Velázquez, J., 1989: Origin and development of allergy in Mexico. Revista Alergia Mexico 36(2): 39-42

Mcmahon, L.R.; Jones, S.L.; Gilliland, T.R.; Hall, W.D.; Wellman, P.J., 1999: Effects of ephedrine enantiomers on conditioned taste aversion and kaolin intake in rats. The ephedrine (EPH) enantiomers, (-)-EPH and (+)-EPH, have different biological activity in the rat, with the (-)-EPH enantiomer exerting a greater impact on suppression of feeding, induction of locomotion, and activation of brown adipose tissue t...

Sotto Escobar A.; Llorca M.; Castro R.; Perez A.; Landa M.; Estrada M.; Soria C.; Acosta M.; Martinez J.; E.A., 1990: Association of cimetidine and metronidazole in three different doses for gastroduodenal ulcers. A blind randomized study was performed to 186 patients with gastroduodenal ulcer. Three therapeutical schemes associating cimetidine and metronidazole at different doses were used; to the first group was administered 400 mg of cimetidine and 740 m...

Rupiper, D.J., 1998: Diseases that affect race performance of homing pigeons. Part II: bacterial, fungal, and parasitic diseases. Diagnosis and treatment of bacterial, mycotic and parasitic diseases are reviewed. Among the bacterial species that cause disease, Salmonella typhimurium var. copenhagen, Escherichia coli and a group of bacteria that are associated with chronic re...

Vazquez W.D.; Yeomans E.; Lally K.P., 1991: Intrauterine transfusion an unusual cause of bowel perforation in the neonate. Pediatric Surgery International 6(2): 138-139

John, M.T.; Reissmann, D.R.; Schierz, O.; Allen, F., 2008: No significant retest effects in oral health-related quality of life assessment using the Oral Health Impact Profile. Objective. To investigate retest effects in assessment of the Oral Health Impact Profile (OHIP) in patients requiring prosthodontic treatment. Material and methods. The German 49-item OHIP was administered in 21 patients requiring prosthodontic t...

Carlisle, D., 1997: New protection for old. Nursing Times 93(3): 18-19

Oliva, Adriana, 1994: A revision of the genus Hemiosus SHARP, 1882 in South America (Coleoptera: Hydrophilidae). A key to the South-American species of Hemiosus is given, with localities. Nine new species are described; two in the maculatus-group: H. aequatorialis sp. nov. from Venezuela and Peru and H. irinus sp. nov. from North-eastern Argentina; seven in...

Kassich, Y.Y.; Podnyakova, V.N.; Khomenko, V.I.; Simonov, B.P.; Myand, A.E.; Petukhov, V.I.; Magda, V.I., 1986: Pasteurization of milk from tuberculosis-infected herds by infra-red electrical heating. A system for pasteurizing milk by electrical IR heating at 77 degrees C, with 30 s holding, is described and shown in a diagram. The milk circulates through quartz glass tubes and is irradiated at 2800-3200 nm, producing a uniform heating density...