geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Hyperammonemia associated with valproic acid concentrations


, : Hyperammonemia associated with valproic acid concentrations. Biomed Research International 2014: 217269-217269

Valproic acid, a branched short-chain fatty acid, has numerous action mechanisms which turn it into a broad spectrum anticonvulsant drug and make its use possible in some other pathologies such as bipolar disorder. It is extensively metabolized in liver, representing β -oxidation in the mitochondria one of its main metabolic route (40%). Carnitine is responsible for its entry into the mitochondria as any other fatty acid. Long-term high-dose VPA therapy or acute VPA overdose induces carnitine depletion, resulting in high levels of ammonia in blood. As a high correlation between salivary valproic acid levels and plasma ultrafiltrate levels was found in humans, saliva becomes a promising monitoring fluid in order to study valproic acid pharmacokinetics and its toxic effect. Extended-release (twice daily) formulations of valproic acid or carnitine supplementation are the proposed two therapeutic strategies in order to reverse hyperammonemia.

US$19.90

PMID: 24868521

DOI: 10.1155/2014/217269


Other references

Tunç, H.; Oken, O.; Kara, M.; Tiftik, Tülay.; Doğu, B.; Unlü, Z.; Ozçakar, L., 2012: Ultrasonographic measurement of the femoral cartilage thickness in hemiparetic patients after stroke. The aim of the study was to evaluate the femoral cartilage thicknesses of hemiparetic patients after stroke using musculoskeletal ultrasonography and to determine whether there is any correlation between cartilage thicknesses and the clinical char...

Ventura, M.T.; Giuliano, G.; D.C.rato, R.; Tursi, A., 1998: Modulation of eosinophilic chemotaxis with azelastine and budesonide in allergic patients. In this paper, the effect of azelastine hydrochloride, a potent inhibitor of leukotrienes (LTs) and H1 receptors for histamine, was assessed as regards modulation of in vitro eosinophilic chemotaxis. In this respect, chemotaxis of eosinophils (EOS...

El-Salhy, M.; Falkmer, S.; Kramer, K.J.; Speirs, R.D., 1984: Immunocytochemical evidence for the occurrence of insulin in the frontal ganglion of a Lepidopteran insect, the tobacco hornworm moth, Manduca sexta L. The frontal ganglion of the adult forms of the tobacco hornworm, Manduca sexta, was investigated immunocytochemically for the occurrence of the gastro-entero-pancreatic (GEP) neurohormonal peptides, namely insulin, nerve growth factor, epidermal g...

Seslija, D.; Tucic, N., 2003: Selection for developmental time in bean weevil (Acanthoscelides obtectus): correlated responses for other life history traits and genetic architecture of line differentiation. In this article we investigate the direct and correlated responses to selection for developmental time in order to discern differences between lines in several preadult and adult life history traits of Acanthoscelides obtectus (Coleoptera, Bruchid...

Jones, PS.; Hurford, C., 1995: Principal bird habitats in Glamorgan. Unknown

Hirai, Heashi, 1956: Response fixation in the white rat. To study the effect of the number of trials with inconsistent reward or punishment on response fixation in a Lashley apparatus, Ss were put in an insoluble situation after either random or discriminative response. Although some differences were ap...

Jennifer Gagliardi-Seeley, 2012: Dominance status reversal based on pair-bond formation in the convict cichlid Amatitlania nigrofasciata. Dominant individuals have access to higher-quality resource; thus, reversing their dominance status would be important for subordinate individuals. Using the convict cichlid fish (<i>Amatitlania nigrofasciata</i>), this study examines...

Yu, Y.; Cao, C.Yan.; Chen, Z.; Liu, H.; Li, P.; Dou, Z.Feng.; Song, W.Guo., 2013: Au nanoparticles embedded into the inner wall of TiO2 hollow spheres as a nanoreactor with superb thermal stability. A new nanoreactor-type composite catalyst with Au NPs embedded into the inner wall of the mesoporous TiO2 hollow spheres resulted in an enhanced synergistic effect and superb thermal stability of highly dispersed Au NPs.

Singh, S.K., 2004: Aquifer response to sinusoidal or arbitrary stage of semipervious stream. Analytical expressions for the aquifer responses, viz., groundwater head, rate of flow and cumulative volume of flow, to a generalized sinusoidal stage of semipervious streams considering the stream boundary resistance, are derived. The analytical...

Daniel, J.L.; Dangelmaier, C.; Smith, J.B., 1992: Evidence that adhesion of electrically permeabilized platelets to collagen is mediated by guanine nucleotide regulatory proteins. Adhesion of electrically permeabilized platelets to collagen was found to be essentially independent of free Ca2+ concentration in the medium. Addition of stable GTP analogues increased the proportion of adhering cells about 5-fold. This effect wa...