geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Hyperglycemia regulates TXNIP/TRX/ROS axis via p38 MAPK and ERK pathways in pancreatic cancer


, : Hyperglycemia regulates TXNIP/TRX/ROS axis via p38 MAPK and ERK pathways in pancreatic cancer. Current Cancer Drug Targets 14(4): 348-356

Approximately 85% of pancreatic cancer patients suffer from glucose intolerance or even diabetes because high glucose levels can contribute to oxidative stress which promotes tumor development. As one of the reactive oxygen species (ROS)-regulating factors, thioredoxin-interacting protein (TXNIP), is involved in the maintenance of thioredoxin (TRX)-mediated redox regulation. In this study, we demonstrated that high glucose levels increased the expression of TXNIP in time- and concentration-dependent manners and modulated the activity of TRX and ROS production in pancreatic cancer cells, BxPC-3 and Panc-1. We also found that glucose activated both p38 MAPK and ERK pathways and inhibitors of these pathways impaired the TXNIP/TRX/ROS axis. Knockdown of TXNIP restored TRX activity and decreased ROS production under high glucose conditions. Moreover, we observed that the integrated optical density (IOD) of TXNIP staining as well as the protein and mRNA expression levels of TXNIP were higher in the tumor tissues of pancreatic cancer patients with diabetes. Taken together, these results indicate that hyperglycemia-induced TXNIP expression is involved in diabetes-mediated oxidative stress in pancreatic cancer via p38 MAPK and ERK pathways.

US$29.90

PMID: 24720336


Other references

Sun, X-Cheng.; Yan, J-Yi.; Chen, X-Lei.; Huang, Y-Peng.; Shen, X.; Ye, X-Hua., 2014: Depletion of telomerase RNA inhibits growth of gastrointestinal tumors transplanted in mice. To explore effects of telomerase RNA-targeting phosphorothioate antisense oligodeoxynucleotides (PS-ASODN) on growth of human gastrointestinal stromal tumors transplanted in mice. A SCID mouse model for transplantation of human gastrointestinal st...

Beck, N.S.; Kang, I.S.; Suh, Y.L., 2001: Protracted diarrhea: results of the five-year survey in a tertiary hospital in Korea. The syndrome of protracted diarrhea (PD) includes several diseases with diverse etiologies. This study was conducted to characterize the spectrum of causes, clinical manifestations, and the outcomes of PD. A retrospective analysis of the clinical...

Lindberg, A.A.; Kärnell, A.; Weintraub, A., 1991: The lipopolysaccharide of Shigella bacteria as a virulence factor. The virulence factors of the lipopolysaccharide of Shigella species bacteria include the endotoxic activities of the lipid A component of the molecule and the ability of the polysaccharide chain--the core and the O-antigenic polysaccharide--to pro...

Zhande, R.; Zhang, W.; Zheng, Y.; Pendleton, E.; Li, Y.; Polakiewicz, R.D.; Sun, X.Jian., 2006: Dephosphorylation by default, a potential mechanism for regulation of insulin receptor substrate-1/2, Akt, and ERK1/2. Protein phosphorylation is an important mechanism that controls many cellular activities. Phosphorylation of a given protein is precisely controlled by two opposing biochemical reactions catalyzed by protein kinases and protein phosphatases. How t...

Finley, William L., 1907: The Grebes of southern Oregon. Condor Pasadena Cal, 9 97-101

Chakraborty, K.P., 1956: Variations in uptake and excretion of radioiodine in the rat following different modes of administration. The variations in uptake and excretion of radio-iodine after intraperitoneal, intraven., intramuscular and subcutaneous injection as well as oral administration with empty stomach, and full stomach, were investigated. 252 rats, divided into groups...

Lose E.G.; Jabro J.D.; Simmons K.E.; Baker D.E., 1992: Simulation of nitrogen dynamics and leaching from arable soils. The LEACHM model was evaluated using data from a field experiment conducted in Lancaster County, Pennsylvania, U.S.A. Many of the parameter input values were the means of determinations for soil samples from the field site. Measured nitrogen (N) u...

Leibman, F.H.; Leibman, N., 1991: Developing trends in prisoners' rights to mental health treatment. American Journal of Forensic Psychology 9(1): 19-28

Lam, C.R., 1982: The Central Surgical Association turns forty. Some highlights of the first twenty years. Henry Ford Hospital Medical Journal 30(2): 77-80

Hartmann E., 1969: Mania depression and sleep. KALES, ANTHONY (EDITED BY) SLEEP PHYSIOLOGY and PATHOLOGY 360P ILLUS J B LIPPINCOTT CO : PHILADELPHIA, PA , U S A 183-191