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Hypocalcemia is related to left ventricular diastolic dysfunction in patients with chronic kidney disease


, : Hypocalcemia is related to left ventricular diastolic dysfunction in patients with chronic kidney disease. Journal of Cardiology 63(3): 198-204

Left ventricular (LV) diastolic dysfunction in patients with chronic kidney disease (CKD) is of a complex nature and is the predominant cause of congestive heart failure in this group of patients. This work aimed to evaluate the potential effect of disturbances in calcium-phosphorus (Ca-P) metabolism in patients with CKD on LV diastolic function as assessed by echocardiography. The study group consisted of 81 ambulatory patients with CKD, stages 2-5, with preserved LV systolic function-LV ejection fraction >50% and with sinus rhythm. Standard echocardiography was performed in all patients with tissue Doppler echocardiography for the evaluation of the systolic velocity and both diastolic velocities of LV (EmLV and AmLV). The following laboratory parameters were measured: serum creatinine concentration, estimated glomerular filtration rate, and the levels of urea, P, Ca, parathormone, platelet count, hemoglobin level, and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels. Patients were divided into two groups according to the results of EmLV: group with LV diastolic dysfunction (EmLV<8cm/s) DF (+) and group with normal LV diastolic function DF (-), when EmLV was ≥8cm/s. Patients in DF (+) group, as compared to DF (-) patients, manifested a lower serum Ca level and an elevated NT-proBNP level [9.03±0.76mg/dL vs 9.44±0.78mg/dL, p=0.02, and 257.9 (32.6-12,633)pg/ml vs 149 (11.7-966)pg/ml, p=0.035, respectively]. The area under the receiver operating characteristics (ROC) curve of Ca for diastolic dysfunction was 0.627, 95% CI (0.511-0.734), p=0.04, whereas ROC derived Ca value of ≤9.82mg/dL was characterized by a sensitivity of 91.8% and specificity of 38.1% for diagnosing LV diastolic dysfunction. The only independent variable predicting LV diastolic dysfunction as measured by a multivariate logistic regression analysis was Ca level≤9.82mg/dL with odds ratio=8.81 (95% CI 1.49-51.82), p=0.014. Hypocalcemia is an independent predictive factor for LV diastolic dysfunction in patients with CKD.

US$19.90

PMID: 24012332

DOI: 10.1016/j.jjcc.2013.08.003


Other references

Sale, J.E.M.; Thielke, S.; Topolovec-Vranic, J., 2010: Who is addicted to, and dying from, prescription opioids?. Journal of the American Geriatrics Society 58(7): 1401-1402

Ebenholtz, S.M., 1977: Determinants of the rod and frame effect the role of retinal size. Base-out prisms were used to alter perceived size and distance to a luminous rod and frame while the retinal size [human] remained unchanged. The rod-and-frame effect (RFE) was the same, whether the display was viewed directly or through the prism...

Voyles W.F.; Runge T.M.; Fisher D.C.; Greene E.R., 1986: Comparative pharmacodynamic actions of cardiac glycosides. Clinical Research 34(1): 15A

Crainz F., 1967: Proteins in the endometrium during the menstrual cycle and after menopause part 6 stroma calculation of histone proteins. Bollettino Societa Italiana Biologia Sperimentale 43(15): 921-923

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Lewis, G.C., 1957: The treatment of primary uterine cervical cancer. Pennsylvania Medical Journal 60(10): 1349-1351

Ryu, H.Jung.; Seo, M.Ryoung.; Choi, H.Jin.; Ko, K-Pil.; Park, P.Whan.; Baek, H.Joo., 2016: Mean platelet volume as a marker for differentiating disease flare from infection in Behçet's disease. The aim of this study was to investigate the association between mean platelet volume (MPV) and clinical manifestations, disease activity or infection in patients with Behçet's disease (BD). In total, 193 patients diagnosed with BD according...

Deng, L-Hau.; Lee, C-Hong., 2014: Multicentric paraspinal neuroglial heterotopia with Müllerian and renal agenesis: a variant of Mayer-Rokitansky-Küster-Hauser syndrome?. Neuroglial heterotopia is a rare congenital anomaly that mostly involves the head and neck region. We report a female fetus with multicentric paraspinal neuroglial heterotopia in the retropharyngeal and retroperitoneal spaces, right renal agenesis...

Myant, N.B., 1952: Observations on the metabolism of human gamma globulin labelled by radioactive iodine. Results suggest a freely exchangeable reservoir of plasma protein, containing about 300 g. This agrees with similar results based on radioactive albumin.

Wood, S.A.; Smith, F.M.J.; Heath, M.W.; Palfroy, T.; Gaw, S.; Young, R.G.; Ryan, K.G., 2013: Within-mat variability in anatoxin-a and homoanatoxin-a production among benthic Phormidium (cyanobacteria) strains. Benthic Phormidium mats can contain high concentrations of the neurotoxins anatoxin-a and homoanatoxin-a. However, little is known about the co-occurrence of anatoxin-producing and non-anatoxin-producing strains within mats. There is also no data...