geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Hypovitaminosis D and K are highly prevalent and independent of overall malnutrition in the institutionalized elderly


, : Hypovitaminosis D and K are highly prevalent and independent of overall malnutrition in the institutionalized elderly. Asia Pacific Journal of Clinical Nutrition 19(1): 49-56

There have been methodological problems for studying hypovitaminosis D and K in the elderly. First, studies were done either by evaluating food intake or measuring their circulating levels, but rarely by both in Japan. In this paper, vitamin D and K intakes and their circulating levels were simultaneously determined. Second issue is whether hypovitaminosis D and K are independent of general malnutrition, prevalent in the elderly. We tried to statistically discriminate them by principal component analysis (PCA). Fifty institutionalized elderly were evaluated for their circulating 25 hydroxy-vitamin D (25OH-D), intact parathyroid hormone (PTH), phylloquinone (PK), menaquinone-7 (MK-7) levels, and their food intake. Although average vitamin D intake (7.0 microg/day) exceeded the Japanese Adequate Intake (AI) of 5.0 microg/day, average serum 25OH-D concentration was in the hypovitaminosis D range (11.1 ng/mL). Median vitamin K intake was 168 microg/day, approximately 2.5 times as high as AI for vitamin K. Nevertheless, plasma PK and MK-7 concentrations were far lower than those of healthy Japanese elderly over 70 years old. PCA yielded four components; each representing overall nutritional, vitamin K2, vitamin D, and vitamin K1 status, respectively. Since these components are independent of each other, vitamin D- and K-deficiency in these subjects could not be explained by overall malnutrition alone. In summary, institutionalized elderly had a high prevalence of hypovitaminosis D and K, and the simultaneous determination of their circulating level and dietary intake is mandatory in such studies. PCA would yield fruitful results for eliminating the interference by confounders in a cross-sectional study.

US$29.90

PMID: 20199987


Other references

McArthur, J.; Hill, J.; Paech, M.J.; Dodd, P.H.; Bennett, E-J.; Holden, J., 2005: Cerebrospinal fluid and serum concentrations of beta-trace protein during pregnancy. We conducted a prospective observational study among a cohort of 40 term parturients undergoing spinal anaesthesia for elective Caesarean section, to determine the concentration of beta-trace protein in cerebrospinal fluid (CSF) and serum. Serum a...

Kass, Dl, 1995: Are nitrogen fixing trees a solution for acid soil?. Nitrogen fixing tree research reports: a ication of the Nitrogen Fixing Tree Association NFTA: 9-31

Vilstrup, H., 2004: Cirrhosis and bacterial infections. Half of cirrhosis patients die within two years after diagnosis, in most cases from cirrhosis related causes; most frequently variceal bleeding closely followed by infections. There seems to exist associations between infection and other complicat...

Einset, J., 1972: Lakemont and Suffolk Red seedless grapes named. A brief summary is given of the breeding programme in New York for seedless grapes, including the selection of three varieties from a cross of Ontario X Sultanina, of which Himrod has the best eating quality The new variety Lakemont produces mediu...

Kara, T.; Younes, M.; Erol, B.; Karcaaltincaba, M., 2012: Evaluation of testicular vein anatomy with multidetector computed tomography. We aimed to evaluate the normal anatomy and variations of testicular veins by multidetector CT (MDCT).This prospective study included 11 male patients who underwent abdominal CT for various clinical indications. Mean age of patients was 53 years....

Tyrer, P.; Shawcross, C., 1988: Monoamine oxidase inhibitors in anxiety disorders. Monoamine oxidase inhibitors (MAOI's) have been shown to be significantly superior to placebo in the treatment of some anxiety disorders, particularly agoraphobia and mixed anxiety--depressive states. There is no convincing evidence that MAOI...

Karlbom, U.; Graf, W.; Nilsson, S.; Påhlman, L., 1996: Does surgical repair of a rectocele improve rectal emptying?. This study was undertaken to assess results of surgical repair of rectocele and to identify possible determinants of outcome from patient's history and preoperative defecography. Another aim was to evaluate how surgery affects rectal evacuati...

Lorenzon, G.; Rico, A.; Fournier, G.; Thouvenot, J.P., 1986: Distribution and elimination of vanadium in mice following a four weeks intraperitoneal administration of sodium orthovanadate. Journal de Toxicologie Clinique et Experimentale 6(4): 229-236

Coleman J.M.; Prior D.B.; Bryant W.R., 1981: Sedimentation processes and seismic facies in the late Pleistocene/ Holocene Mississippi River delta depocenter. Annual Research Conference: Coast Section. Society of Economic Paleontologists and Mineralogists. Program and Abstracts. 2, Pages 25-26. 1981.

Pritzker, J.; Jungkunz, R., 1943: Ueber Johan-nisbrotmehl des Handels. Commercial carob bean flour was examined in detail by recent methods. Sucrose and invert sugar total 32%, starch 3.5%, aqueous extract 48.6%. Carob bean kernels contain neither starch nor sugar, but instead 44.9% mucous substances and pectin, and...