+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Identification and evaluation of anti-inflammatory compounds from Kaempferia parviflora

, : Identification and evaluation of anti-inflammatory compounds from Kaempferia parviflora. Bioscience, Biotechnology, and Biochemistry 78(5): 851-860

The rhizome of Kaempferia parviflora has been used in traditional Thai medicine. In this study, we identified and compared specific compounds from the hexane extract of K. parviflora with those from other Zingiberaceous plants by using gas chromatography-mass spectrometry. We identified 5,7-dimethoxyflavone (DMF), 5-hydroxy-3,7,3',4'-tetramethoxyflavone (TMF), estimated 3,5,7-trimethoxyflavone, 5-hydroxy-7,4'-dimethoxyflavone, 3,5,7,4'-tetramethoxyflavone, and investigated their anti-inflammatory effects in rat basophilic leukemia (RBL-2H3) cells stimulated with an IgE antigen or a calcium ionophore. We found that DMF and TMF more potently inhibited antigen-induced degranulation than did nobiletin, a well-known anti-inflammatory agent. In addition, compared to RBL-2H3 cells stimulated with a calcium ionophore, those treated with DMF and TMF showed more marked inhibition of the degranulation and the production and mRNA expression of inflammatory mediators. These results suggest that DMF and TMF inhibit an early step in the high-affinity IgE receptor signaling cascade rather than intracellular calcium release and protein kinase C activation.


PMID: 25035989

DOI: 10.1080/09168451.2014.905177

Other references

Hiruta, O.; Yamamura, K.; Takebe, H.; Futamura, T.; IInuma, K.; Tanaka, H., 1997: Application of Maxblend Fermentor for microbial processes. Application of the Maxblend impeller (which was originally developed for mixing high viscous liquids during chemical reactions) to a bioreactor (Maxblend Fermentor (MBF)) was investigated. In comparison with turbine impeller fermentor (TBN), the M...

Trabelsi, S.; Mrad, K.; Driss, M.; Ben Romdhane, K., 2001: Disseminated peritoneal leiomyomatosis: apropos of a case with immunohistochemical study. We report one case of leiomyomatosis peritonealis disseminata in a 40-year-old woman, G4P4, who never used oral contraceptives. She had relapsing uterine leiomyoma resected twice by hysteroscopy. Clinical findings and imaging studies concluded to...

Sarkar, N.K.; Fuys, R.A.; Stanford, J.W., 1979: The chloride corrosion of low-gold casting alloys. Potentiodynamic polarization measurements have indicated that the so-called 'low-gold' casting alloys are characterized by decreased chloride corrosion resistance, when compared with ADA Type III and Type IV gold alloys. This decrease in...

Luthe, R.; Lukáts, E., 1976: Psychosomatic disorders in criminals during imprisonment. Results of a survey and case report. Bibliotheca Psychiatrica: 124-140

Connors B.W.; Prince D.A., 1982: Effects of local anesthetic qx 314 2 2 6 di methylphenylamino n n n triethyl 2 oxo ethanaminium on the membrane properties of hippocampal pyramidal neurons. The quaternary lidocaine derivative QX-314 was applied internally to CA1 pyramidal neurons of the guinea pig hippocampal slice preparation. This local anesthetic blocked both fast Na+-dependent action potentials and the voltage-dependent, non-inac...

Tomita, M.; Aramaki, O.; Kawasaki, A.; Mimatsu, K.; Kuboi, Y.; Kanou, H.; Oida, T.; Amano, S., 2008: A case of aneurysm of the gastroduodenal artery related to stenosis of the superior mesenteric artery treated with transcatheter embolization. We report a case of an aneurysm of the gastroduodenal artery. An 86-year-old woman was admitted to our hospital for treatment of an aneurysm that was found incidentally by abdominal contrast enhancement computed tomography (CECT). Angiography dem...

Gramse, Leonard J., 2003: Implantable medical device with full metallic case. An implantable electronic tissue stimulating device for providing therapy to a patient is contained within an full metallic case resulting in reduced size, reduced assembly time, reduced parts cost and reduced labor cost, limits the exposure of th...

Hubert, B.; Adam, F., 1985: Outbreaks of Mastomys erythroleucus and Taterillus gracilis in the Sahelo-Sudanian zone in Senegal. Acta Zoologica Fennica, 113-117 No. 173

Alcorn, G.D., 1949: Nesting of the Glaucous-winged Gull at Tacoma, Washington. Murrelet Seattle, 30: 59

Cohen A.I., 1970: Relationship between rat adipose size lipolytic sensitivity to norepinephrine and adenyl cyclase activity. Physiologist: 218