+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Identification and functional analysis of antifungal immune response genes in Drosophila

, : Identification and functional analysis of antifungal immune response genes in Drosophila. Plos Pathogens 4(10): E1000168-E1000168

Essential aspects of the innate immune response to microbial infection appear to be conserved between insects and mammals. Although signaling pathways that activate NF-kappaB during innate immune responses to various microorganisms have been studied in detail, regulatory mechanisms that control other immune responses to fungal infection require further investigation. To identify new Drosophila genes involved in antifungal immune responses, we selected genes known to be differentially regulated in SL2 cells by microbial cell wall components and tested their roles in antifungal defense using mutant flies. From 130 mutant lines, sixteen mutants exhibited increased sensitivity to fungal infection. Examination of their effects on defense against various types of bacteria and fungi revealed nine genes that are involved specifically in defense against fungal infection. All of these mutants displayed defects in phagocytosis or activation of antimicrobial peptide genes following infection. In some mutants, these immune deficiencies were attributed to defects in hemocyte development and differentiation, while other mutants showed specific defects in immune signaling required for humoral or cellular immune responses. Our results identify a new class of genes involved in antifungal immune responses in Drosophila.


PMID: 18833296

DOI: 10.1371/journal.ppat.1000168

Other references

Yang, Q-tao.; Gu, J.; Zhang, Y-chun.; Zhu, Z-hui.; Yang, Y-an.; Wang, N.; Zhu, Q-liang., 2015: Effects of stanniocalcin-1 and hypoxia-inducible factor-1α on mitochondrial membrane potential stability in renal carcinoma cells. To explore the effects of stanniocalcin-1 (STC-1) and hypoxia-inducible factor-1α (HIF-1α) on the calcium and thus on the mitochondrial membrane potential (Δψm) in renal carcinoma cells. We successfully established the renal carcinoma cell mod...

Ivliev A.I. (Ivliyev A.I.; Badjukov D.D. (Badyukov D.D.; Kashkarov L.L., 1995: Thermoluminescence measurements in shocked oligoclase. Abstracts of Papers Submitted to the Lunar and Planetary Science Conference: art 2; Pages 663-664. 1995.

Schirmer, W.J.; Schirmer, J.M.; Galat, J.A.; Fry, D.E., 1989: Systemic and renal hemodynamic response to platelet activating factor. Progress in Clinical and Biological Research 299: 227-232

Van Dongen, H.P.A.; Kerkhof, G.A.; Kloeppel, H.B.rnd, 1997: Seasonal covariation of the circadian phases of rectal temperature and slow wave sleep onset. There is a scarcity of well-controlled studies of the seasonal variation in circadian rhythmicity. In the present study, the circadian phase of rectal temperature and the onset of slow wave sleep were studied in a series of twelve 24-h experiments...

Mueller, U.; Leucht, W.; Reinecke, P.; Dalle, T., 1999: Breeding and biological evaluation of yield selection in dairy cattle. In the course of natural selection metabolic pathways has been improved with regard to reproductive fitness. Yield selection, however, aimes at specific alterations in favour of other traits. The directed reorganization of the genotypic and metabo...

Desai, N.C.; Chouhan, B.S.; Qureshi, M.S.; Sharma, S.R., 1977: Eye diseases in primary school children in Jodhpur. Indian Journal of Ophthalmology 25(1): 11-12

Taylor, M.; Ashcroft, A.T.; Messenger, A.G.; Westgate, G.E.; Gibson, W.T., 1991: Glycosaminoglycans in the extracellular matrix and medium of cultured human hair papilla cells. Annals of the New York Academy of Sciences 642: 446-447

Simon Martin, F.; Rojo Vazquez, FA., 1985: Prevalencia de Sanguinicola sp. (Digenea: Sanguinicolidae) en Ancylus fluviatilis (Basomathophora: Ancylidae) de un rio de la Provincia de Salamanca. Revista Iberica de Parasitologia, 453: 265-266

Locatelli, B.G.; Frawley, G.; Spotti, A.; Ingelmo, P.; Kaplanian, S.; Rossi, B.; Monia, L.; Sonzogni, V., 2008: Analgesic effectiveness of caudal levobupivacaine and ketamine. Background. Ketamine is used increasingly in paediatric anaesthetic practice to prolong the action of a caudal block. This study was designed to determine if adding S(+)-ketamine 0.5 mg kg(-1) allows a lower concentration of levobupivacaine to be...

Shrapnel, W., 2016: Trends in Sugar-Sweetened Beverages: Are Public Health and the Market Aligned or in Conflict?. Adverse health consequences of consuming sugar-sweetened beverages are frequently cited as an example of market failure, justifying government intervention in the marketplace, usually in the form of taxation. However, declining sales of sugar-swee...