geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Identification of potent and selective VEGFR receptor tyrosine kinase inhibitors having new amide isostere headgroups


, : Identification of potent and selective VEGFR receptor tyrosine kinase inhibitors having new amide isostere headgroups. Bioorganic & Medicinal Chemistry Letters 20(3): 848-852

A novel series of malonamide-type dual VEGFR2/c-Met inhibitors in which one of the amide bonds was replaced by an amide isostere-a trifluoroethylamine unit, was designed, synthesized, and evaluated for their enzymatic and cellular inhibition of VEGFR2 and c-Met enzymes. Optimization of these molecular entities resulted in identification of potent and selective inhibitors of VEGFR2 enzyme.

US$19.90

PMID: 20071170

DOI: 10.1016/j.bmcl.2009.12.099


Other references

Griffin, D.; Martino, M.A.; Hoffman, M.S., 2004: Superior vena cava syndrome during chemotherapy for stage 3c fallopian tube adenocarcinoma. Background. Superior vena cava syndrome is most often encountered in patients with malignancies. The diagnosis constitutes an oncologic emergency with prompt treatment indicated to manage the acute symptoms. There are few reports describing the sy...

Filippini C.; Sonnleitner B.; Fiechter A., 1992: Intelligent analytical subsystems for on line control and monitoring of bioprocesses. A general concept is presented for the integration of analytical subsystems in automated bioprocess control. The requirements and characteristic properties for an "intelligent" analytical subsystem are discussed. The realization of the c...

Stevens, D.P.; Killworth, P.D., 1992: The distribution of kinetic energy in the Southern Ocean A comparison between observations and an eddy resolving general circulation model. Philosophical Transactions of the Royal Society of London B Biological Sciences 338(1285): 51-57

Wales, L.; Jenkins, D.P.; Smith, P.L., 2001: Delayed presentation of right ventricular bullet embolus. Venous bullet embolism to the heart is a rare complication of penetrating gunshot trauma. There are little data regarding long-term follow-up of missiles retained in the right ventricle. We report a rare case of right ventricular bullet embolus fo...

Jung, S.; Rosini, J.M., 2017: Dexmedetomidine for Treatment of Refractory Heroin Withdrawal. Journal of Emergency Nursing: Jen 43(2): 182-184

Shi, Z-hong.; Li, S-kai.; Li, Y-qun.; Yin, N-bei.; Xiong, B.; Zhao, Z-min., 2007: Unilateral buccinator myomucosal island flap with double opposing Z-plasty for wider palatal cleft repair. To explore a method to repair larger cleft palate and lengthen soft palate without oral palate raw surface and scar formation, reduce the effect on maxilla and dental arch development. A modified double opposing Z-plasty was used to lengthen soft...

Feiwel, M., 1965: Cystic acne of infancy. British Journal of Dermatology 77(8): 465-466

Zhuravlev, A.I.; Veselovski, V.A.; Koshchenko, N.N., 1965: Bioluminescence and chemoluminescence of some organic compounds. Uspekhi Sovremennoi Biologii (Adv Mod Biol): 602 5): 161-177

Kim, M.Ki.; Won, D-Youn.; Lee, J-Kwon.; Kang, W-Kyung.; Kye, B-Hyeon.; Cho, H-Min.; Kim, H-Jin.; Kim, J-Gi., 2016: Laparoscopic Surgery for Transverse Colon Cancer: Short- and Long-Term Outcomes in Comparison with Conventional Open Surgery. Published studies on laparoscopic surgery for transverse colon cancer are scarce. More studies are necessary to evaluate the feasibility, safety, and long-term oncologic outcomes of laparoscopic surgery for transverse colon cancer. From April 1996...

Gershuni, G.V., 1959: Central regulation of discharges in the peripheral neuron of the auditory system. Diminution of the electrical responses of the first neuron in the auditory system of chronic animals (cats and hens) was seen both under conditions producing external inhibition (during the execution of orientation reactions to non-auditory stimul...