geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

IgE/antigen-mediated enhancement of IgE production is a mechanism underlying the exacerbation of airway inflammation and remodelling in mice


, : IgE/antigen-mediated enhancement of IgE production is a mechanism underlying the exacerbation of airway inflammation and remodelling in mice. Immunology 144(1): 107-115

IgE is known to enhance some antibody responses to specific antigens, but whether this contributes to allergic asthma remains unclear. We have previously found that repeated antigen challenges in mice sensitized with antigen-specific IgE monoclonal antibody (mAb) exacerbated airway inflammation and remodelling accompanied by increased levels of endogenous antigen-specific IgE and IgG1. Here, we investigated whether IgE/antigen-mediated enhancement of endogenous IgE production contributes to the exacerbation of airway inflammation and remodelling. BALB/c mice passively sensitized with ovalbumin (OVA) -specific IgE mAb were challenged with OVA intratracheally seven times; anti-IgE mAb was intraperitoneally administered 1 day before the fourth challenge. Treatment with anti-IgE mAb inhibited the increased level of endogenous OVA-specific IgE in serum, but not OVA-specific IgG1, and a biphasic increase in airway resistance at the fourth challenge. Furthermore, a biphasic increase in airway resistance, airway hyper-responsiveness to methacholine, OVA-specific IgE and IgG1 production, and infiltrations by neutrophils and eosinophils in the lungs at the seventh challenge were suppressed by treatment; airway remodelling, such as goblet cell hyperplasia and sub-epithelial fibrosis, was also reduced. In addition, the production of interleukin-17A, interleukin-33 and CXCL1 in the lungs related to these IgE-mediated responses was decreased by treatment. Collectively, we found that the mechanism leading to the exacerbation of allergic asthma is closely related to IgE/antigen-mediated enhancement of IgE production, suggesting that this may create a vicious circle leading to the chronic status in asthmatic patients having levels of antigen-specific IgE ready to form complexes with antigen.

US$19.90

PMID: 24995892

DOI: 10.1111/imm.12355


Other references

Subba Rao G.; Ramasarma T., 1971: Rhythmic activity of biogenesis of cholesterol. Environmental Physiology 1(4): 188-197

Lauciani, E., 1982: Soil classification and land classification applied to irrigation projects. Idrotecnica (4) 177-196

Saling, M.; Koprdová, I.; Hrubý, M.; Hlavacka, F., 1991: Quantitative evaluation of disorders of upright posture using stabilometry. The authors examined, using the stabilometric method, 14 patients with lesions of the cerebellum, vestibular system and cerebral hemispheres (hemiparetics). Quantitative evaluation of the stability of posture was done using 7 parameters under four...

Nair, P.M.; Chacko, A.; Venugopalan, P., 2002: Accidental tricyclic antidepressant poisoning in a 2 year-old boy. We present a 2-year old boy with accidental ingestion of a tricyclic antidepressant and outline the clinical features, management and prevention. Despite ingesting a high dose of amitriptyline (20mg/kg) and showing serum levels above the toxic ran...

Elliott Gavin; Shannon Patrick M.; Haughton Peter, 2005: Palaeogene sedimentary architecture of the NE Rockall Basin. Irish Journal of Earth Sciences 23: 130

Vorotilov, M.A., 1957: Protein requirement of calves. Three groups of 10-month old Whitehead and Kazakh calves were given rations of steppe hay, maize silage, cereals, sunflower cake and minerals. The groups received 100, 125 or 150 g. digestible protein per feed unit. Weight increases in 4 months we...

Parajuli, B.; Fishel, M.L.; Hurley, T.D., 2014: Selective ALDH3A1 inhibition by benzimidazole analogues increase mafosfamide sensitivity in cancer cells. Aldehyde dehydrogenase enzymes irreversibly oxidize aldehydes generated from metabolism of amino acids, fatty acids, food, smoke, additives, and xenobiotic drugs. Cyclophosphamide is one such xenobiotic used in cancer therapies. Upon activation, c...

Mercer, R.T.; Ferketich, S.L., 1988: Stress and social support as predictors of anxiety and depression during pregnancy. Four groups, 153 high-risk women, 75 high-risk mates, 218 low-risk women, and 147 low-risk mates, were studied during the 24th to 34th weeks of pregnancy. Hierarchical regression analysis was used to study the effect of stress, social support (per...

Vazzana, Angelo., 1997: Benthonellania benestarensis sp n from the Tortonian of Benestare Reggio Calabria Benthonellania benestarensis sp n del Tortoniano di Benestare Reggio Calabria. Bollettino Malacologico. 1996( ); 321-4: 7-10

Campbell, L.G.; Seiler, G.J., 1994: Internal CO-2 concentration as a selection criterion for storage respiration rate in sugarbeet. Respiration is responsible for much of the sucrose loss that occurs during sugarbeet (Beta vulgaris L.) storage. Genotypes with reduced storage respiration rates would provide an efficient method for reducing sucrose losses. However, the current t...