+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Immunoblastic follicular lymphoma: a very unusual transformation of low-grade follicular lymphoma

, : Immunoblastic follicular lymphoma: a very unusual transformation of low-grade follicular lymphoma. Human Pathology 45(11): 2359-2363

A 73-year-old man, in clinical remission 17 years after radiation therapy for a localized low-grade follicular lymphoma (FL), developed extensive lymphadenopathy, ascites, and splenomegaly with splenic masses. Axillary lymph node biopsy showed FL composed of nodules of centrocytes side by side with nodules of immunoblasts rather than centroblasts. Immunophenotyping revealed conventional FL markers (BCL-2, BCL-6, and CD10) as well as MUM-1 in the immunoblastic component, suggesting postgerminal center differentiation. Fluorescence in situ hybridization showed t(14;18) in both centrocytic and immunoblastic components and a copy gain of BCL-6 predominantly in the immunoblastic component. Areas of centrocytic and of immunoblastic nodules were macrodissected separately and underwent molecular evaluation for immunoglobulin heavy chain gene rearrangement. Identical base-pair peaks were found, attesting to their clonal identity. This case represents a very unusual example of transformation of a low-grade FL to a nodular immunoblastic FL.


PMID: 25223592

DOI: 10.1016/j.humpath.2014.07.016

Other references

Wiercinski F.J., 1971: The dynamic action of the sarcolemma. Journal of General Physiology 57(2): 253-254

Anonymous, 1956: Wheat cross promising. Mention is made of selections from Improved Blue Jacket x Comanche tested in Oklahoma. One selection has shown stiff straw and good baking quality.

Attree, O.; Olivos, I.M.; Okabe, I.; Bailey, L.C.; Nelson, D.L.; Lewis, R.A.; Mcinnes, R.R.; Nussbaum, R.L., 1992: The lowe's oculocerebrorenal syndrome gene encodes a protein highly homologous to inositol polyphosphate 5 phosphatase. Lowe's oculocerebrorenal syndrome (OCRL) is a human X-linked developmental disorder of unknown pathogenesis and has a pleiotropic phenotype affecting the lens, brain and kidneys. The OCRL locus has been mapped to Xq25-q26 by linkage and by fi...

Hinderliter, A.L.; Willis, P.W.V.; Li, S.; Koch, G.; Clayton, L.; Group, T.N.rth American Primary Pulmonary Hypertension Study, 1996: Echocardiographic predictors of exercise capacity in primary pulmonary hypertension. Journal of the American College of Cardiology 27(2 SUPPL A): 212A

Xu, X.F.; Wang, Z.W.; Su, S.Z., 1983: Comparative observations on the salivary gland chromosomes of the fourth instar larva of Anopheles sinensis in various districts. Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 1(2): 91-94

James-Pirri, M.-Jane; Roman, C.T.; Swanson, J.L., 2010: A Method to Quantitatively Sample Nekton in Salt-Marsh Ditches and Small Tidal Creeks. We designed a novel gear to quantitatively sample nekton (free-swimming fish and crustaceans) from salt-marsh ditches and small tidal creeks. This gear, the ditch net, is portable and inexpensive to manufacture, and many replicate samples can be s...

Deshpande, A.L.; Sehgal, S.P., 1964: Blight of FoenIculum vulgare Mill, caused by Alternaria tenuis Auct. tenuis on fennel was 1st observed in India in 1962 and has since caused heavy losses. Infection is confined mostly to the inflorescence, the buds turning pale yellow and losing turgidity, later becoming light brown and dried; occasionally they are...

Verma, A.; Kilicaslan, F.; Martin, D.O.; Minor, S.; Starling, R.; Marrouche, N.F.; Almahammed, S.; Wazni, O.M.; Duggal, S.; Zuzek, R.; Yamaji, H.; Cummings, J.; Chung, M.K.; Tchou, P.J.; Natale, A., 2005: Preimplantation B-type natriuretic peptide concentration is an independent predictor of future appropriate implantable defibrillator therapies. Objective: To assess prospectively whether preimplantation B-type natriuretic peptide (BNP) and C reactive protein (CRP) concentrations predict future appropriate therapies from an implantable cardioverter-defibrillator (ICD).Design and setting: P...

Mate N.B.; Maru G.B.; Bhide S.V., 1981: Studies on tumorigenicity and metabolism of isoniazid in mice and rats. Tumorigenicity of isoniazid (INH) in Swiss mice and Wistar rats was studied when INH was administered by gavage feeding 6 times a wk. Tumors were observed in 55% of INH fed mice; no tumors were observed in treated rats. Mice had slower rate of ace...

Piskunov, S.Z.; Piskunov, G.Z.; Erofeeva, L.N.; Lazarev, A.I.; Popova, F.I., 1989: Use of polymer-based drugs in the treatment of acute and chronic maxillary sinusitis. The 5-year experience gained in the ENT hospital of the Kursk Medical Institute and the ENT department of the Central Hospital of the USSR Ministry of Health proved effective the use of polymer-based drugs in chemotherapy of acute and chronic maxi...