geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Immunological reactivity against neuronal and non-neuronal antigens in sporadic adult-onset cerebellar ataxia


, : Immunological reactivity against neuronal and non-neuronal antigens in sporadic adult-onset cerebellar ataxia. European Neurology 62(6): 356-361

In recent years, the involvement of the immune system in acquired forms of cerebellar ataxia has been frequently demonstrated. In this study, we describe 6 out of 49 patients with subacute or chronic progressive cerebellar ataxia in whom antibodies against neuronal and non-neuronal antigens were identified. Two women had anti-Yo antibodies; two patients had anti-gliadin antibodies in the presence of celiac disease; one patient had a complex autoimmune disorder associated with anti-Ro-52/SS-A and anti-muscle-specific kinase antibodies, and a patient developed subacute cerebellar syndrome associated with the presence of a prostatic adenocarcinoma and atypical antibodies reacting both with cerebellar tissue and with the prostatic tumor. Our study confirms previous findings in paraneoplastic syndromes, and indicates that at least 10% of sporadic cerebellar ataxia may be related to immune-mediated mechanisms.

US$19.90

PMID: 19786780

DOI: 10.1159/000242010


Other references

Katinas, V.Ya, 1964: The comparative physiology of the tonus of higher regions in the brain. The work was aimed at elucidating the stages of the tonus formation of the higher parts of the central nervous system and the mechanisms of its regulation. The comparative-physiological aspect of investigation was applied, account being taken of t...

D.B.eecker, J.; D.R.uck, J.; Van Landegem, W.; Meersman, G., 1988: Hypertrophy of the inferior olivary nucleus. A clinico-pathological observation. The clinico-pathological findings in a 61-year-old man, who suffered from branchial and skeletal myoclonus, appearing six months after a brainstem infarction are reported. Of all the drugs which are usually thought to be effective in the treatment...

Ryser, Fc, 1986: Grafting of hickories. Annual report of the Northern Nut Growers Association: 7th) 43-45

Kodukula, K.; Arcuri, M.; Cutrone, J.Q.; Hugill, R.M.; Lowe, S.E.; Pirnik, D.M.; Shu, Y.Z.; Fernandes, P.B.; Seethala, R., 1995: BMS-192548, a tetracyclic binding inhibitor of neuropeptide Y receptors, from Aspergillus niger WB2346. I. Taxonomy, fermentation, isolation and biological activity. During the screening of microbial fermentation extracts for their ability to inhibit the binding of 125I-peptide YY (PYY) to the neuropeptide Y (NPY) receptor using the scintillation proximity assay (SPA), BMS-192548 was isolated from the extract...

Jakubovský, J.; Brozman, M.; Chorváth, D.; Růzickova, M.; Surmiková, E.; Zaviacic, M.; Blazeková, J., 1979: Morphology of systemic anaphylactic reaction in rabbits to bovine serum albumin and ferritin. I. Manifestations of the reaction after antigen administration: laboratory, macroscopic and optical microscopic findings. A report is presented on systemic anaphylactic reaction [SAR] of rabbits to bovine serum albumin and ferritin. Active anaphylactic sensibilization with a high yield of sensibilized animals was achieved by administering antigens to rabbits aged a f...

Zigmond, J., 2008: Flying in the face of danger. A spate of air ambulance crashes has raised questions about safety, but providers say the service offers overwhelming benefits. The first six months of 2008 brought a distressing number of air ambulance crashes, including one in late June that claimed six lives. But providers say the benefits far outweigh the risks. "Our job is to provide healthcare to our patients as...

Sakthivel, G.; Rajasekar, S., 2010: Diffusion dynamics and first passage time in a two-coupled pendulum system. We present the numerical investigation of diffusion process and features of first passage time (FPT) and mean FPT (MFPT) in a two-coupled damped and periodically driven pendulum system. The effect of amplitude of the external periodic force and ph...

Marte, A.; Pintozzi, L.; Cretì, G.; Chiesa, P.Lelli.; Renzo, D.Di.; Gasparella, M.; Maggio, G.Di.; Bagnara, V.; Merlini, E.; Tadini, B.; Caldarulo, E.; Sangiorgio, L.; Battaglino, G.; Nappo, S.Gerocarni.; Caione, P., 2016: Long-Term Follow-Up of Testicular Microlithiasis in Children and Adolescents: Multicenter Prospective Cohort Study of the Italian Society of Pediatric Urology. NlmCategory="UNASSIGNED"><b>Introduction</b> Testicular microlithiasis (TM), characterized by the presence of intratubular calcifications in a single or both the gonads, is an uncommon entity with unknown etiology and ou...

Etzkorn, K.P.; DeGuzman, L.J.; Holderman, W.H.; Abu-Hammour, A.; Schlesinger, P.K.; Harig, J.M.; Watkins, J.L., 1995: Endoscopic drainage of pancreatic pseudocysts: patient selection and evaluation of the outcome by endoscopic ultrasonography. Endoscopy 27(4): 329-333

Kalinowska, B., 1976: Jirgl's test in the differential diagnosis of jaundice. Wiadomosci Lekarskie 29(7): 585-586