geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Impact of CD44+CD24- cells on non-sentinel axillary lymph node metastases in sentinel node-positive breast cancer


, : Impact of CD44+CD24- cells on non-sentinel axillary lymph node metastases in sentinel node-positive breast cancer. Oncology Reports 25(4): 1109-1115

Although complete axillary lymph node dissection (ALND) is the standard for evaluating axillary status after the identification of a positive sentinel lymph node (SLN) in breast cancer; approximately 40-60% of SLN-positive patients have negative non-SLN. In this study, to explore putative breast cancer stem cells with CD44+CD24- in the SLN, we retrospectively analyzed the expression of CD44+CD24- on metastatic tumor cells within SLNs as a predictive factor for positive non-SLNs (NSLNs). We tested 271 patients for SLNs using serial sectioning with cytokeratin immunohistochemistry (IHC) and hematoxylin-eosin staining and identified 67 patients who had a positive SLN biopsy and complete ALND. CD44 and CD24 expression was detected using double-staining IHC. Twenty-eight (41.8%) out of 67 patients had positive NSLN metastases. Seven positive SLNs with micrometastases were not available for the evaluation of CD24 and CD44 expression. Out of the remaining 60 patients, 19 (31.7%), 44 (73.83%) and 37 (61.7%) patients had CD24+, CD44+ and CD44+CD24- metastatic tumor cells in SLNs, respectively. Positive NSLN metastasis was significantly associated with the primary tumor size (P=0.004), CD24- expression (P=0.04), CD44+ expression (P=0.01) and CD44+CD24- expression (P=0.02). This report provides the first evidence of the existence of a putative stem-like phenotype within the SLN, which is significantly associated with positive NSLN in early breast cancer patients.

US$19.90

PMID: 21308353

DOI: 10.3892/or.2011.1177


Other references

Ekenga, C.C.; Parks, C.G.; Sandler, D.P., 2016: A prospective study of occupational physical activity and breast cancer risk. Physical activity has been associated with reduced breast cancer risk, but studies of occupational activity have produced inconsistent results. The purpose of this study was to evaluate the relationship between occupational physical activity and b...

Baburina, E.A.; Buznikov, G.A., 1957: The hatching glands of Kuban embryos of Vimba vimba carinata as a source of hyaluronidase and of the hatching enzyme. CR Acad Sci URSS: 113: 1387-1390

Drossman, D.A., 1997: Irritable bowel syndrome and sexual/physical abuse history. There is growing evidence that a history of sexual or physical abuse can affect emotional and physical well-being. Within gastroenterology, attention has focused on the increased frequency of abuse history, particularly for patients with refractor...

Thomovsky, S.A.; Packer, R.A.; Burcham, G.N.; Heng, H.Gan., 2011: Imaging diagnosis-magnetic resonance imaging features of metastatic cerebral lymphoma in a dog. We describe histopathologically confirmed intracranial metastasis of cutaneous lymphoma. In magnetic resonance (MR) images there was a heterogeneous, contrast-enhancing, extraaxial mass in the right parietal and piriform lobes at the level of the...

Bross, S.; Braun, P.M.; Michel, M.S.; Juenemann, K.P.; Alken, P., 2003: Bladder wall tension during physiological voiding and in patients with an unstable detrusor or bladder outlet obstruction. To develop and evaluate a new clinical method for measuring bladder wall tension (BWT) on detrusor contraction during physiological voiding and under pathological conditions, as in experimental trials during subvesical obstruction the ability to g...

Wang, L.; Xu, J.; Li, F.; Zhan, H.; Liu, H.; Chen, W.; Hu, S., 2017: Partial Splenectomy is Superior to Total Splenectomy for Selected Patients with Hemangiomas or Cysts. The superiority of partial splenectomy (PS) as a treatment for benign tumors has not well been confirmed. This study aimed to identify the short- and long-term outcomes of PS, to compare laparoscopic and laparotomic PS, and to demonstrate whether...

Kang, C., 2011: Risks and characteristics of injuries in older adults in Korea. Journal of the American Geriatrics Society 59(6): 1146-1148

Zwingmann, C.; Flögel, U.; Pfeuffer, J.; Leibfritz, D., 2000: Effects of ammonia exposition on glioma cells: changes in cell volume and organic osmolytes studied by diffusion-weighted and high-resolution NMR spectroscopy. NH(4)Cl (10 mM) caused a sustained increase in the cell volume in immobilized, perfused F98 glioma cells to approx. 125% of control after 3 h, as measured by diffusion-weighted (1)H NMR spectroscopy. Concomitantly, the glutamine (Gln) concentratio...

Terlau, H.; Seifert, W., 1990: Fibroblast Growth Factor Enhances Long-term Potentiation in the Hippocampal Slice. Recently we reported that perfusion of hippocampal slices with epidermal growth factor (EGF) lead to enhancement of potentiated responses after tetanic stimulation. In the present study we report that basic fibroblast growth factor (FGF) can also...

Attman, G.; Hallén, O.; Lindström, J.; Persson, K., 1976: Disposable syringe for irrigation of impacted cerumen. Lakartidningen 73(9): 736-736