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Improvement of the metabolic syndrome profile by soluble fibre - guar gum - in patients with type 2 diabetes: a randomised clinical trial


, : Improvement of the metabolic syndrome profile by soluble fibre - guar gum - in patients with type 2 diabetes: a randomised clinical trial. British Journal of Nutrition 110(9): 1601-1610

A diet rich in fibre seems to protect against the metabolic syndrome (MetS), but there is scarce information about the role of fibre intake in patients with the MetS and diabetes. The aim of the present study was to evaluate the effects of soluble fibre from partially hydrolysed guar gum (PHGG) on the MetS and cardiovascular risk factors in patients with type 2 diabetes. In the present randomised controlled clinical trial, forty-four patients with type 2 diabetes (males 38·6 %, age 62 (SD 9) years, diabetes duration 14·2 (SD 9·6) years) and the MetS underwent clinical, laboratory and dietary evaluations at baseline, 4 and 6 weeks. All patients followed their usual diet and the intervention group (n 23) received an additional 10 g/d of PHGG. In the intervention group, waist circumference (WC), glycated Hb (HbA1c), 24 h urinary albumin excretion (UAE) and serum trans-fatty acids (FA) were reduced in comparison with baseline after 4 and 6 weeks: WC 103·5 (SD 9·5) to 102·1 (SD 10) to 102·3 (SD 9·7) cm; HbA1c 6·88 (SD 0·99) to 6·64 (SD 0·94) to 6·57 (SD 0·84) %; 24 h UAE 6·8 (interquartile range 3·0-17·5) to 4·5 (interquartile range 3·0-10·5) to 6·2 (interquartile range 3·0-9·5) mg; trans-FA 71 (interquartile range 46-137) to 67 (interquartile range 48-98) to 57 (interquartile range 30-110) mg/l (P< 0·05 for all). The only change in the control group was weight reduction: 77·0 (SD 13·5) to 76·2 (SD 13·3) to 76·1 (SD 13·4) kg (P= 0·005). Other MetS components (blood pressure, TAG, HDL-cholesterol, fasting plasma glucose), total and LDL-cholesterol, C-reactive protein and endothelin-1 did not change in either group. In patients with type 2 diabetes and the MetS, the addition of PHGG to the usual diet improved cardiovascular and metabolic profiles by reducing WC, HbA1c, UAE and trans-FA.

US$19.90

PMID: 23551992

DOI: 10.1017/S0007114513001025


Other references

Hofer, M.; Janzowski, C.; Eisenbrand, G., 1994: Detection and quantification of O-6-methyldeoxy-guanosine adducts by 32P-postlabelling. Naunyn-Schmiedeberg's Archives of Pharmacology 349(SUPPL ): R123

Lu, S.; Xu, X.; Xia, F.; Wang, J., 2005: Analysis of gene expression in the K562-n high tumorigenitic human leukemia cell line. OBJECTIVE The human leukemia K562-n cell line displays much higher tumorigenic actively in nude mice compared with its parental K562 cell line. The molecular mechanism of the differences in tumorigenicity between K562-n and K562 in nude mice was e...

Erridge, P.L., 1992: Carriers of infection within the profession. British Dental Journal 172(12): 438-438

Salven, P.; Mustjoki, S.; Alitalo, R.; Alitalo, K.; Rafii, S., 2002: VEGFR-3 and CD133 identify a population of CD34+ lymphatic/vascular endothelial precursor cells. Human CD133 (AC133)(+)CD34(+) stem and progenitor cells derived from fetal liver and from bone marrow and blood incorporate a functional population of circulating endothelial precursor cells. Vascular endothelial growth factor receptor 3 (VEGFR-3)...

Thompson, A.M., 1990: An evaluation of the selection process of hospital information systems. This research study evaluates the selection process of a Hospital Information System (HIS), focusing on the level of compromise required by healthcare professionals during said process and the level of satisfaction achieved with the system selecte...

Ehrich M.; Gross W.B., 1982: Effect of cortico sterone on toxicity of malathion and tri o tolyl phosphate in hens gallus domesticus. Neurobehavioral Toxicology & Teratology 4(6): 789-792

Jing, Y.; Wang, G.; Ge, Y.; Xu, M.; Tang, S.; Gong, Z., 2016: AA-PMe, a novel asiatic acid derivative, induces apoptosis and suppresses proliferation, migration, and invasion of gastric cancer cells. Asiatic acid (AA; 2α,3β,23-trihydroxyurs-12-ene-28-oic acid) is widely used for medicinal purposes in many Asian countries due to its various bioactivities. A series of AA derivatives has been synthesized in attempts to improve its therapeutic p...

Simmons, E.; Langone, A.; Recupero, P.; Mcmonagle, E.; Mcmenamin, E.; Morrow, J.; Himmelfarb, J.; Ikizler, T.A.p, 2003: Renal transplantation improves biomarkers of oxidative stress in patients with end-stage renal disease. Journal of the American Society of Nephrology 14(Abstracts Issue): 654A, November

Gonzalez, N.J., 2014: The history of the enzyme treatment of cancer. No Abstract Available.

Costanzo E.; Costanzo D.J., 1982: Social facilitation of audience reaction to frightening and humorous films. Bulletin of the Psychonomic Society 20(3): 145