geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

In vitro - in vivo evaluation of a new oral dosage form of tramadol hydrochloride--controlled-release capsules filled with coated pellets


, : In vitro - in vivo evaluation of a new oral dosage form of tramadol hydrochloride--controlled-release capsules filled with coated pellets. Acta Poloniae Pharmaceutica 71(3): 469-475

The aim of this study was an in vitro - in vivo evaluation of a new oral dosage form of tramadol hydrochloride (TH), controlled-release capsules filled with coated pellets, 100 mg (TC), compared to the sustained release tablets, Tramal Retard, 100 mg (TR). In vitro release study of both formulations showed a similar release profile of TH over 8 h (f2 was 52). In vivo study (single oral, 100 mg dose administration in 8 rabbits) showed that the amount of TH absorbed into the systemic circulation after TC and TR administration was also similar (90% CI for AUC(0-t) and AUC(0-infinity) were 90-124% and 97-109%, respectively). However, a comparison of AUC(0-t) of pharmacokinetics of TC and TR indicates significantly prolonged absorption and elimination processes of TH when the drug is given in controlled-release capsules filled with coated pellets. It was manifested by longer: mean absorption time (p = 0.0016), mean residence time (p = 0.0268), absorption half-life (p = 0.0016), elimination half-life (p = 0.0493) and lower: absorption rate constant (p = 0.0016), elimination rate constant (p = 0.0148) and total body clearance Cl/F (p = 0.0076). It may be concluded that the new TH formulation could be expected to have a more prolonged analgesic activity than commercial sustained release tablets.

US$29.90

PMID: 25265827


Other references

Pangaro, L.N., 2015: Two Cheers for Milestones. Journal of Graduate Medical Education 7(1): 4-6

Kiyohara, T.; Abe, M.; Saitoh, Y.; Itakura, H.; Nakamura, M., 1992: In vivo activation of killer cells by anti-cancer chemotherapies or radiation therapies. Natural Immunity 11(5): 254

Assael B.M.; Chiabrando C.; Gagliardi L.; Noseda A.; Bamonte F.; Salmona M., 1985: Prostaglandins and aminoglycoside nephrotoxicity. The role of prostaglandins in the development of aminoglycoside-induced acute rena failure was studied in CD-COBS rats (200-250 g). The animals were treated with gentamicin (80 mg/kg), acetylsalicylic acid (ASA, 100 or 200 mg/kg) or both drugs or...

Pratt, I.; Herrmann, R., 1962: Nitzschia quadritesta sp.n. (Monogenea: Capsalidae) from the Columbia river sturgeon. Nitzschia quadritestes n.sp. is described from the gills of Acipenser transmontame from the brackish-water region of the Columbia River, Oregon (U.S.A.). N. quadritestes is differentiated from the other species of the genus by the size and shape o...

Mitchell, R.A.; Theobald, J.C.; Parry, M.A.; Lawlor, D.W., 2000: Is there scope for improving balance between RuBP-regeneration and carboxylation capacities in wheat at elevated CO2?. Carboxylation and RuBP-regeneration capacities, which determine light-saturated photosynthetic rate, were analysed in leaves of spring wheat (Triticum aestivum cv. Minaret) grown under different atmospheric CO2 partial pressure (pCa) and N supply...

Bruck, 1969: Differential therapy with various cardiac pacemaker types. Medizinische Klinik 64(28): 1293

Prickett, C.; LeGrand, P., 1984: Complications of fiberoptic bronchoscopy in a community hospital. Alabama Medicine 53(8): 25-27

Ito, A.; Abe, N.; Fujii, T.; Hayashi, A.; Ueno, A.; Mugikura, S.; Takahashi, S.; Mori, E., 2012: The contribution of the dorsolateral prefrontal cortex to the preparation for deception and truth-telling. Recent neuroimaging evidence suggests that the dorsolateral prefrontal cortex is associated with creating deceptive responses. However, the neural basis of the preparatory processes that create deception has yet to be explored. Previous neuroimagi...

Shen, W.; Slaughter, M.M., 1999: Internal calcium modulates apparent affinity of metabotropic GABA receptors. The metabotropic GABA receptor (GABA(B)R) regulates calcium influx in neurons. Whole cell voltage-clamp techniques were employed to determine the effects of internal calcium on the activity of GABA(B)Rs. GABA(B)R receptor apparent affinity was max...

Moran, Reid, 1961: Stegnosperma cubense and Gossypium klotzschianum davidsonii not known in the Revillagigedos. Reports evidently are based on misinterpretation of labels.