+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

In vivo lung microvasculature visualized in three dimensions using fiber-optic color Doppler optical coherence tomography

, : In vivo lung microvasculature visualized in three dimensions using fiber-optic color Doppler optical coherence tomography. Journal of Biomedical Optics 18(5): 50501-50501

For the first time, the use of fiber-optic color Doppler optical coherence tomography (CDOCT) to map in vivo the three-dimensional (3-D) vascular network of airway segments in human lungs is demonstrated. Visualizing the 3-D vascular network in the lungs may provide new opportunities for detecting and monitoring lung diseases such as asthma, chronic obstructive pulmonary disease, and lung cancer. Our CDOCT instrument employs a rotary fiber-optic probe that provides simultaneous two-dimensional (2-D) real-time structural optical coherence tomography (OCT) and CDOCT imaging at frame rates up to 12.5 frames per second. Controlled pullback of the probe allows 3-D vascular mapping in airway segments up to 50 mm in length in a single acquisition. We demonstrate the ability of CDOCT to map both small and large vessels. In one example, CDOCT imaging allows assignment of a feature in the structural OCT image as a large (∼1  mm diameter) blood vessel. In a second example, a smaller vessel (∼80  μm diameter) that is indistinguishable in the structural OCT image is fully visualized in 3-D using CDOCT.


PMID: 23625308

DOI: 10.1117/1.JBO.18.5.050501

Other references

Hsu, W.C.; Huang, F.Y.; Lee, H.C.; Shin, S.L., 1991: Microcolon in newborns: clinical significance and differential diagnosis. Microcolon is a radiological finding of a colon of tiny caliber on barium enema examination. There are no absolute standards for measurement of this condition which is probably caused in utero by lack of appropriate distention of the colon with in...

Bocsa, I., 1958: New phenomena in hemp inbreeding. Inbreeding in a monecious line developed at Kompolt, Hungary, resulted in a decrease in the vegetative period in segregating male and female individuals compared with noninbred controls. Some female plants showed certain male characters, together...

Thatch, Dw, 1980: An integration of industry and classroom in graduate research: a case study. The purpose of this paper is to report and evaluate an ongoing graduate research program that has used a number of company and governmental researchers to help students contrast similarities and differences and gain a better understanding of univ...

Collin, T.; Chat, M.; Lucas, M.Gabrielle.; Moreno, H.; Racay, P.; Schwaller, B.; Marty, A.; Llano, I., 2005: Developmental changes in parvalbumin regulate presynaptic Ca2+ signaling. Certain interneurons contain large concentrations of specific Ca2+-binding proteins (CBPs), but consequences on presynaptic Ca2+ signaling are poorly understood. Here we show that expression of the slow CBP parvalbumin (PV) in cerebellar interneur...

Hazell, S.; Rogers, D., 2005: Mosquito-borne flaviviruses and human disease. Mlo: Medical Laboratory Observer 37(5): 16-8, 20; Quiz 22-3

El-Domyati, M.; Abd-El-Raheem, T.; Medhat, W.; Abdel-Wahab, H.; A.A.wer, M., 2014: Multiple fractional erbium: yttrium-aluminum-garnet laser sessions for upper facial rejuvenation: clinical and histological implications and expectations. Fractional photothermolysis is a modern resurfacing technique, in which microscopic zones of thermal injury are created, stimulating turnover of both epidermis and dermis. Fractional laser rejuvenation has been developed to overcome the drawbacks...

Kurer, H.G., 1989: Ancorextra anchors--a risk of fracture. British Dental Journal 166(9): 320-320

Kaukal', V.G., 1981: Age-related changes in the fingernails. Sudebno-Meditsinskaia Ekspertiza 24(2): 35-36

Nikolić, S.; Zivković, V., 2015: A train-related fatality--old dilemmas: accident, suicide, or homicide? Premortem or postmortem decapitation?. Forensic Science, Medicine, and Pathology 10(2): 278-283

Mulkey, W.; Mclemore, W.; Talbot, T.; Labonte, D., 1994: Yield test: early #1B. LAES mimeo series: 9) 101