geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

In vivo telemetric determination of shear and axial loads on a regenerative cartilage scaffold following ligament disruption


, : In vivo telemetric determination of shear and axial loads on a regenerative cartilage scaffold following ligament disruption. Journal of Biomedical Materials Research. Part B, Applied Biomaterials 102(7): 1415-1425

Recent interest in repair of chondral and osteochondral cartilage defects to prevent osteoarthritis caused by ligament disruption has led to the research and development of biomimetic scaffolds combined with cell-based regeneration techniques. Current clinical focal defect repair strategies have had limited success. New scaffold-based approaches may provide solutions that can repair extensive damage and prevent osteoarthritis. This study utilized a novel scaffold design that accommodated strain gauges for shear and axial load monitoring in the canine stifle joint through implantable telemetry technology. Loading changes induced by ligament disruption are widely implicated in the development of injury-related osteoarthritis. Seeding the scaffold end with progenitor cells resulted in higher shear stress than without cell seeding and histology showed significantly more bone and cartilage formation. Biomechanically, the effect of transecting the anterior cruciate ligament was a significant reduction in braking load in shear, but no change axially, and conversely a significant reduction in push-off load axially, but no change in shear. This is the first study to report shear loads measured directly in knee joint tissue. Further, advances of these measurement techniques are critical to developing improved regeneration strategies and personalizing reliable rehabilitation protocols.

US$19.90

PMID: 24678004

DOI: 10.1002/jbm.b.33120


Other references

Lepreau, F.J., 1991: One physician's mission. Rhode Island Medical Journal 74(4): 179-182

Sicuteri, F., 1981: Enkephalinase inhibition relieves pain syndromes of central dysnociception (migraine and related headache). Normotensive and hypertensive headache sufferers were treated with D-phenylalanine, aprotinin or captopril--all inhibitors of endogenous opioid degradation. Inconsistent results were obtained using D-phenylalanine and aprotinin (acute administrati...

Gupta, P.D.; Thorsteinson, A.J., 1960: Food plant relationships of the diamond-back moth (Plutella maculipennis (Curt.)). I. Gustation and olfaction in relation to botanical specificity of the larva. The following is based on the authors' summary. The food-plant range of Plutella maculipennis (Curt.) has been shown in Canada to be essentially coincident with the botanical distribution of mustard oils and their gluco-sides . The exclusion...

Sato'o, Y.; Hisatsune, J.; Hirakawa, H.; Ono, H.K.; Omoe, K.; Sugai, M., 2017: Complete Sequence of a iStaphylococcus aureus Clonal Complex 81 Strain, the Dominant Lineage in Food Poisoning Outbreaks in Japan. <i>Staphylococcus aureus</i> No. 10 is an isolate from a staphylococcal food poisoning outbreak in Japan, classified as clonal complex 81 subtype 1. It preferentially produces larger quantities of staphylococcal enterotoxin A (SEA) and...

Miyamura, Sadao, 1951: On the influence of pH of sample on the cup assay of antibiotics. In the cup assay method the diam. of the inhibition zone decreases with increasing pH in the case of penicillin and aureomycin, increases in the case of streptomycin, and remains constant in the case of chloramphenicol.

Klie, W., 1943: Susswasserostrocoden aus Sudosteuropa. Zoologischer Anzeiger Leipzig, 183: 233-244

Koziorowski, A.; Radwan, L., 1962: Use of the capnograph in the determination of partial pressure of carbon dioxide in mixed venous and in arterial blood with the aid of repeated respiration. Polskie Archiwum Medycyny Wewnetrznej 32: 1543-1552

Kleinschmidt, H., 1963: On the treatment of oxyuriasis vermicularis with pyrvinium pamoate. Die Medizinische Welt 7: 377-379

Hampl, H.; Ludat, K.; Stabell, U.; Jehle, P.M., 1999: Growth hormone therapy in uremic patients increases parathyroid hormone levels and improves growth retardation and bone turnover. Journal of the American Society of Nephrology 10(PROGRAM AND ABSTR ISSUE): 598A, Sept

Ordobás Gavín, Mía.; Cañellas Llabrés, S.; Garcia Fernández, C.; García Comas, L.; Gutiérrez Rodríguez, M.Angeles.; Rodero Garduño, I.; García Gutierrez, J.; Ramirez Fernández, R.; Rodríguez Artalejo, Fándo., 2008: Tuberculosis in the Autonomous region of Madrid, Spain. Incidence among foreign and Spanish individuals during the 1996-2004 period. Immigration from countries having a high prevalence of tuberculosis to other more highly-developed countries has a bearing on the overall evolution of tuberculosis in the latter. This study is aimed at describing the influence of the cases of tube...