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Individual susceptibility to hypoperfusion and reductions in exercise performance when perfusion pressure is reduced: evidence for vasodilator phenotypes


, : Individual susceptibility to hypoperfusion and reductions in exercise performance when perfusion pressure is reduced: evidence for vasodilator phenotypes. Journal of Applied Physiology 117(4): 392-405

The primary objective of this study was to determine whether cardiovascular compensatory response phenotypes exist in the face of a reduced perfusion pressure challenge to exercising muscle oxygen delivery (O2D), and whether these responses might be exercise intensity (EI) dependent. Ten healthy men (19.5 ± 0.4 yr) completed two trials of progressive forearm isometric handgrip exercise to exhaustion (24.5 N increments every 3.5 min) in each of forearm above and below heart level [forearm arterial perfusion pressure (FAPP) difference of 29.5 ± 0.97 mmHg]. At the end of each EI, measurements of forearm blood flow (FBF; ml/min) via brachial artery Doppler and echo ultrasound, mean arterial blood pressure (MAP; mmHg) via finger photoplethysmography, and exercising forearm venous effluent via antecubital vein catheter revealed distinct cardiovascular response groups: n = 6 with compensatory vasodilation vs. n = 4 without compensatory vasodilation. Compensatory vasodilators were able to blunt the perfusion pressure-evoked reduction in submaximal O2D in the arm-above-heart condition, whereas nonvasodilators did not (-22.5 ± 13.6 vs. -65.4 ± 14.1 ml O2/min; P < 0.05), and in combination with being able to increase O2 extraction, nonvasodilators defended submaximal V̇o2 and experienced less of an accumulated submaximal O2D deficit (-80.7 ± 24.7 vs. -219.1 ± 36.0 ml O2/min; P < 0.05). As a result, the compensatory vasodilators experienced less of a compromise to peak EI than nonvasodilators (-24.5 ± 3.5 N vs. -52.1 ± 8.9 N; P < 0.05). In conclusion, in the forearm exercise model studied, vasodilatory response phenotypes exist that determine individual susceptibility to hypoperfusion and the degree to which aerobic metabolism and exercise performance are compromised.

US$19.90

PMID: 24970851

DOI: 10.1152/japplphysiol.01155.2013


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Kartalov, A.; Jankulovski, N.; Kuzmanovska, B.; Zdravkovska, M.; Shosholcheva, M.; Spirovska, T.; Petrusheva, A.Panovska.; Tolevska, M.; Srceva, M.; Durnev, V.; Jota, G.; Selmani, R.; Sivevski, A., 2016: Effect of Adding Dexamethasone as a Ropivacaine Adjuvant in Ultrasound-Guided Transversus Abdominis Plane Block for Inguinal Hernia Repair. The transverses abdominals plane block (TAP) is a regional anesthesia technique that provided analgesia to the parietal peritoneum, skin and muscles of the anterior abdominal wall. The aim of this randomized double-blind study was to evaluate post...

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Gorelova O.A.; Rzherzhabek I.; Korzhenevskaya T.G.; Butenko R.G.; Gusev M.V., 1985: Influence of the cyanobacterium chlorogloeopsis fritschii on the growth and biosynthetic activity of solanum laciniatum cells grown in a mixed culture. The cells of nightshade (Solanum laciniatum Ait.) and nitrogen-fixing cyanobacterium (Chlorogloeopsis fritschii Mitra) were grown in mixed suspension culture in various media. In nitrogen-containing media and cyanobacterium and its culture fluid d...

Charlier, J.R.; Thomas, P.; Beaune, D.; Reveillere, C.; Buquet, C., 1997: Visual scanning strategies in schizophrenia. Investigative Ophthalmology & Visual Science 38(4 PART 1-2): S652

Kobayashi H.; Kusakabe I.; Okumura M.; Murakami K., 1986: Substrate specificity of the milk clotting enzyme from irpex lacteus on peptide hormones. To clarify the substrate specificity of the milk-clotting enzyme excreted by Irpex lacteus (IR), various peptide hormones were used as substrates to find the cleavage sites and to compare the specificity with those of other milk-clotting enzymes s...

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Burkinshaw, J., 1964: Subsequent Infection Of Infants Born In A Maternity Hospital. A Trial Of A Staphylococcal Vaccine And Toxoid And A Study Of The Relation Between Infection In The Maternity Hospital And Subsequent Infection. Archives of Disease in Childhood 39: 485-491

Meyer Arendt Klaus J.; Kohn Pete A.; Kelley Walter E., 1992: Shoreline changes at Ocean Springs, Mississippi, 1990-1992. Journal of the Mississippi Academy of Sciences 37(1): 42

Zappoli, R., 1957: Episodic psychic disturbances in epileptics; 5 cases of epileptic twilight states. Rassegna di Studi Psichiatrici 46(2): 137-164

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