geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Induction of amnesia induced by disturbance of memory consolidation by antagonists of glutamate or serotonin receptors will be suppressed by the protein synthesis inhibitor


, : Induction of amnesia induced by disturbance of memory consolidation by antagonists of glutamate or serotonin receptors will be suppressed by the protein synthesis inhibitor. Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 96(12): 1212-1222

We have previously found two stages of amnesia evoked by disruption of memory reconsolidation with MK-801 (NMDA glutamate receptors antagonists) application in food aversion conditioned snails. Repeated conditioning restored the food aversion at early stage of amnesia development (<10 days), whereas repeated conditioning 10 days after MK-801 application did not restore the food aversion. In present work, amnesia was induced with MK-801/reminding 24 hours after food aversion conditioning, and antiamnestic effects of NMDA receptor glycine site agonist d-cycloserine were studied at early (3rd day) or late (12th day) stages of amnesia development. D-cycloserine injection and reminding restored memory only 3 days after amnesia induction whereas d-cycloserine injection without reminding was ineffective. D-cycloserine injection and reminding as well as repeated learning 12 days after amnesia induction were also ineffective in memory restoration. Thus, for the first time, it is revealed that NMDA receptor agonist d-cycloserine influences the memory restoration processes only at early but not the later stages of amnesia development.

US$29.90

PMID: 21473108


Other references

Bes-Rastrollo, M.; Wedick, N.M.; Martinez-Gonzalez, M.Angel.; Li, T.Y.; Sampson, L.; Hu, F.B., 2009: Prospective study of nut consumption, long-term weight change, and obesity risk in women. Data concerning the long-term association between nut consumption and weight change in a free-living population are sparse. The objective was to determine the relation between nut consumption and long-term weight change. The participants were 51,1...

Allocca, M.; Crosignani, A.; Gritti, A.; Ghilardi, G.; Gobatti, D.; Caruso, D.; Zuin, M.; Podda, M.; Battezzati, P.M., 2006: Hypercholesterolaemia is not associated with early atherosclerotic lesions in primary biliary cirrhosis. Background: Hypercholesterolaemia often occurs in primary biliary cirrhosis (PBC) as a result of chronic cholestasis, but whether these patients are exposed to greater cardiovascular risk is unknown.Aim: To establish whether hypercholesterolaemia...

Deshwal, R.; Tiwari, D.; Singh, R., 2017: Clinical and Biochemical Characteristics of Exertional Heat Stroke among Paratroopers in Agra, India. The purpose of this study was to assess the clinical profile, biochemical parameters and outcome in a series of 78 patients of heat stroke admitted and treated in a military hospital in India. This was a prospective study in a military hospital. A...

Zaltz, I.; Hosalkar, H.; Wenger, D., 2012: What's new in pediatric orthopaedic surgery. Journal of Bone and Joint Surgery. American Volume 94(4): 375-381

Ahmed, R.P.H.; Biswas, A.; Kannan, M.; Bhattacharya, M.; Geisen, C.; Seifried, E.; Oldenburg, J.; Saxena, R., 2005: First report of a FVII-deficient Indian patient carrying double heterozygous mutations in the FVII gene. Thrombosis Research 115(6): 535-536

Shimura, S., 1994: Lung adenocarcinoma, Clara cell type. Ryoikibetsu Shokogun Shirizu: 41-44

Glasnov, T., N.; Vugts, D., J.; Koningstein, M., M.; Desai, B.; Fabian, W., M.F.; Orru, R., V.A.; Kappe, C.O.iver, 2006: Microwave-assisted Dimroth rearrangement of thiazines to dihydropyrimidinethiones: Synthetic and mechanistic aspects. The Dimroth rearrangement of a set of substituted 2-amino-6H-1,3-thiazines into 3,4-dihydropyrimidine-2-thiones was investigated. The rearrangements were carried out under microwave irradiation conditions in batch or continuous flow format, employ...

Demadis, K.D.; Barouda, E.; Raptis, R.G.; Zhao, H., 2008: Metal tetraphosphonate "wires" and their corrosion inhibiting passive films. Herein, we describe the preparation and characterization of five new divalent metal tetraphosphonates, M-HDTMP [M = Mg(2+), Ca(2+), Sr(2+), Ba(2+), and Cu(2+); HDTMP = hexamethylenediaminetetrakis(methylenephosphonate) dianion]. Materials {Sr[(HDT...

Gill, D.M., 1976: Multiple roles of erythrocyte supernatant in the activation of adenylate cyclase by Vibrio cholerae toxin in vitro. Peptide A1 of Vibrio cholerae toxin, nicotinamide adenine dinucleotide, adenosine triphosphate, and a soluble protein present in erythrocyte supernatant are required for the activation of pigeon erythrocyte ghost adenylate cyclase but are not requ...

Allenmark, S.; Chelminska-Bertilsson, M.; Thompson, R.A., 1990: N-(9-acridinyl)-bromoacetamide--a powerful reagent for phase-transfer-catalyzed fluorescence labeling of carboxylic acids for liquid chromatography. Phase-transfer-catalyzed esterification of various carboxylic acids has been carried out on a microanalytical scale with a new reagent, N-(9-acridinyl)-bromoacetamide, in aqueous/organic two-phase systems. The procedure gives esters showing very h...