geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Induction of iNOS by Chlamydophila pneumoniae requires MyD88-dependent activation of JNK


, : Induction of iNOS by Chlamydophila pneumoniae requires MyD88-dependent activation of JNK. Journal of Leukocyte Biology 84(6): 1585-1593

Innate immune cells produce NO via inducible NO synthase (iNOS) in response to certain infections or upon stimulation with cytokines such as IFN-gamma and TNF. NO plays an important role in host defense against intracellular bacteria including Chlamydophila pneumoniae as a result of its microbicidal activity. In MyD88-deficient mice, which succumb to C. pneumoniae infection, iNOS induction is impaired 6 days postinfection, although pulmonary levels of IFN-gamma and TNF are elevated as in wild-type mice at this time-point. Here, we demonstrate that induction of iNOS in macrophages upon C. pneumoniae infection is controlled by MyD88 via two pathways: NF-kappaB activation and phosphorylation of the MAPK JNK, which leads to the nuclear translocation of c-Jun, one of the two components of the AP-1 complex. In addition, phosphorylation of STAT1 and expression of IFN regulatory factor 1 (IRF-1) were delayed in the absence of MyD88 after C. pneumoniae infection but not after IFN-gamma stimulation. Taken together, our data show that for optimal induction of iNOS during C. pneumoniae infection, the concerted action of the MyD88-dependent transcription factors NF-kappaB and AP-1 and of the MyD88-independent transcription factors phosphorylated STAT1 and IRF-1 is required.

US$19.90

PMID: 18799752

DOI: 10.1189/jlb.0508304


Other references

Jiang, J.; Ni, L., 2017: Arthroscopic internal drainage and cystectomy of popliteal cyst in knee osteoarthritis. The purpose of this study was to evaluate the efficacy of arthroscopic knee cavity internal drainage and cyst cavity debridement operation of popliteal cyst in knee osteoarthritis patients. From August 2007 to March 2013, 58 knee osteoarthritis pa...

de Mucciarelli, S.I.; de Arellano, M.L.; de Lúquez, N.G.; Cid, J.; Fernández, S., 1987: Effects of treatment with polyvinylpyrrolidone on nutritional quality of sorghum. The purpose of this paper was to show that a high polyphenolic compound content in the sorghum grain (Sorghum saccharatum, var sugar drip) has an unfavorable influence on the nitrogen absorption. In order to arrive at this conclusion, the tannin c...

Uslu, M.; Inanmaz, M.E.; Ozsahin, M.; Isık, C.; Arıcan, M.; Gecer, Y., 2014: Cohesive taping and short-leg casting in acute low-type ankle sprains in physically active patients. Cohesive taping is commonly used for the prevention or treatment of ankle sprain injuries. Short-leg cast immobilization or splinting is another treatment option in such cases. To determine the clinical efficacy and antiedema effects of cohesive t...

Dalmasso, A.; Cuani, A., 1976: Resistance of vine stocks to populations of Meloidogyne hapla of different origins. Nine populations of Meloidogyne hapla of different origins were used to test the resistance of 6 common grapevine root-stocks in pot experiments. 41B was always the most infected, followed by S04. In general, Riparia, Rupestris and 99R were the le...

Idrissi, H Rguibi; Thevenot, M.; Bairlein, F.; Dakki, M., 2002: Premiers cas de nidification de la rousserolle effarvatte Acrocephalus scirpaceus a Sidi Bou Ghaba (littoral nord-Atlantique du Maroc). Alauda 70(1): 223-225

Cepin, S., 1982: Systems of cattle meat production. Sodobno kmetijstvo 15(10): 385-388

Li, J.H.; Johnson, D.P.; Dijkstra, P.; Hungate, B.A.; Hinkle, C.R.; Drake, B.G., 2007: Elevated CO2 mitigates the adverse effects of drought on daytime net ecosystem CO2 exchange and photosynthesis in a Florida scrub-oak ecosystem. Drought is a normal, recurrent feature of climate. In order to understand the potential effect of increasing atmospheric CO2 concentration (C-a) on ecosystems, it is essential to determine the combined effects of drought and elevated C-a (E-C) un...

Ernstrom C.A.; Sutherland B.J.; Jameson G.W., 1980: Cheese base for processing a high yield product from whole milk by ultra filtration. Whole milk of normal pH or acidified to pH 5.7 was concentrated by ultrafiltration to 40% original milk weight, diafiltered at constant volume until a desired ratio of lactose to buffer capacity was established, and concentrated by ultrafiltration...

Ufer, Max., 1933: Investigations on climatic factors which affect seed-setting in lucerne. In continuation of a previous study (Herb. Abst. 3. 42. 1933) a number of experiments have been conducted in the artificial tripping of lucerne flowers by means of (a) a burning glass (effective within 5 to 30 seconds) and (b) the employment of th...

Elias, E.; Lesnick, G.J., 1960: Malignant disease in the aged: review of 16 years experience in a modern medical facility for the elderly. American Journal of the Medical Sciences 239: 554-561