+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Influence of bile acid derivates on tramadol analgesic effect in mice

, : Influence of bile acid derivates on tramadol analgesic effect in mice. European Journal of Drug Metabolism and Pharmacokinetics 35(1-2): 75-78

Influence of two newly synthesized bile acids derivates, namely sodium salt of monoketocholic acid MKH-Na and methyl ester of monoketocholic acid MKH-Me on tramadol (12.5 mg/kg oral and intramuscular) analgesic effect was examined in this research. Analgesic effect was measured by antinociceptive hot plate method. Interaction was estimated by detection of changes in analgesic effect of tramadol combined with bile acids (subcutaneous administration of 4 mg/kg 20 min before tramadol) compared to analgesic effect of the same dose of tramadol given alone. Hydrosoluble sodium salt of monoketocholic acid did not show interaction with tramadol, regardless of the route of administration of tramadol. However, methyl ester of monoketocholic acid increased the analgesic effect of tramadol when it was given intramuscularly. After oral administration of tramadol, methyl ester of monoketocholic acid decreased the analgesic effect of tramadol. According to the time point when interaction reached statistically significant difference, it can be presumed that after intramuscular administration of tramadol, methyl ester of monoketocholic acid increases tramadol absorption and transport to brain and in that way increases its analgesic effect. The analgesic effect of tramadol after oral administration was decreased, which could be explained by the induction of tramadol metabolism in the liver, but should be examined in more details.


PMID: 21495270

Other references

Burnhill, M.S.; Birnberg, C.H., 1967: Uterine perforation with intrauterine contraceptive devices. Review of the literature and cases reported to the National Committee on Maternal Health. The National Committee on Maternal Health reported on 28 cases of pe rforation of the uterus in a total of 16,338 first insertions of IUDs after confinement, an incidence of 1.7 perforations per 1000 insertions. 20 of the perforations followed the...

Navakatikian, A.O., 1987: Problems in the development of research on the physiology and psychology of the work of human operators in the Ukrainian SSR. Fiziologicheskii Zhurnal 33(5): 36-42

Yoon, J.Won.; Jung, H.Seung.; Jang, J.Young.; Kim, M.Joo.; Kim, J.Hee.; Ohn, J.Hun.; Kim, J.Hyeon.; Lee, H.Mo.; Kim, H.Cheol.; Lee, K.Bun.; Choi, S.A.; Kim, S-Whe.; Park, K.Soo., 2016: Improved Insulin Secretion by Autologous Islet Transplantation, Compared to Oral Antidiabetic Agents, After Distal Pancreatectomy. In this study, the effects of autologous islet transplantation (ITx) were compared to those of oral antidiabetic drugs (OAD) after distal pancreatectomy (NCT01922492). We enrolled nondiabetic patients who underwent distal pancreatectomy for benign...

Fei, J.; Ranis, G., 1969: Agriculture in the open economy. Role Agr Econ Develop Conf Univ nat Bur Comm Econ Res: 29-164

Enns, R.A.; Mcdougall, B.; Kooner, H.; Halparin, L.; Whittaker,; Amar, J.; Chaun, H.; Atkinson, K., 2002: Prospective randomized trial of argon plasma coagulation versus multipolar electrocoagulation in the ablation of Barretts esophagus without dysplasia Preliminary results. Gastroenterology 122(4 Suppl 1): A 685, April

Tsujita, M.; Sakurai, S., 1969: Incorporation of 14C-phenylalanineor 14C-tyrosine into the hypodermal cuticle of the silkworm. 1. Lethal lemon larvae. Rep. natn. Rep. natn. Inst. Genet. Misima, 20: 39

Elefant, E., 1997: Vitamin A. Consequence of a deficiency, of excessive vitamin A, and value of systematic supplementation. Journal de Gynecologie, Obstetrique et Biologie de la Reproduction 26(3 Suppl): 95-99

Fofaria, N.M.; Ranjan, A.; Kim, S-Hoon.; Srivastava, S.K., 2015: Mechanisms of the Anticancer Effects of Isothiocyanates. Cancer results from aberrant signaling pathways that result in uncontrolled cellular proliferation. The epidemiological studies have shown a strong inverse correlation between dietary consumption of cruciferous vegetables and incidences of cancer....

McCoy, T., 2016: Fluoride-Releasing Restorative Materials. Journal of Veterinary Dentistry 32(3): 196-197

Marsland, D.; Hobbs, C.M.; Sauvé, P.S., 2014: Volar locking plate fixation of distal radius fractures: use of an intra-operative 'carpal shoot through' view to identify dorsal compartment and distal radioulnar joint screw penetration. We report our experience using a 'carpal shoot through' view of the distal radius to identify dorsal compartment screw penetration intra-operatively when performing volar plating of the distal radius. A prospective study of 42 patients (...